ChemicalBook > CAS DataBase List > 4,6-Dichloropyrimidine

4,6-Dichloropyrimidine

Uses

Product Name: 4,6-Dichloropyrimidine
CAS No.: 1193-21-1
Chemical Name: 4,6-Dichloropyrimidine
Synonyms: NSC 37530;4,6-DichL;DichloropyriMidine;IFLAB-BB F2124-0077;4,6-Dichloropyrimidi;4,6-Dichloropyridine;4,6-Dichlorpyrimidin;4,6-Dichoropyrimidine;4,6-DICHLOROPYRIMIDINE;4,6-Dichloro-1,3-diazine
CBNumber: CB6473590
Molecular Formula: C4H2Cl2N2
Formula Weight: 148.98
MOL File: 1193-21-1.mol

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4,6-Dichloropyrimidine Property

Melting point:: 65-67 °C (lit.)
Boiling point:: 176 °C (lit.)
Density: 1.6445 (rough estimate)
vapor pressure: 30-390Pa at 20-50℃
refractive index: 1.6300 (estimate)
Flash point:: 176°C
storage temp.: Inert atmosphere,2-8°C
solubility: 95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to yellow
form: Crystals
pka: -4.20±0.17(Predicted)
color: Yellow-green
BRN: 111195
InChIKey: XJPZKYIHCLDXST-UHFFFAOYSA-N
LogP: 1.45 at 25℃ and pH7.2
Surface tension: 65.72mN/m at 1g/L and 20℃
CAS DataBase Reference: 1193-21-1(CAS DataBase Reference)
NIST Chemistry Reference: Pyrimidine, 4,6-dichloro-(1193-21-1)

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Safety

Hazard Codes: C
Risk Statements: 34-20/21/22-36/37
Safety Statements: 26-36/37/39-45-27
RIDADR: UN 3263 8/PG 2
WGK Germany: 3
F: 19
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: II
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 145378
Product name: 4,6-Dichloropyrimidine
Purity: 97%
Packaging: 10g
Price: $94.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 145378
Product name: 4,6-Dichloropyrimidine
Purity: 97%
Packaging: 50g
Price: $228.9
Updated: 2025/07/31

TCI Chemical

Product number: D2488
Product name: 4,6-Dichloropyrimidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: D2488
Product name: 4,6-Dichloropyrimidine
Purity: >98.0%(GC)
Packaging: 25g
Price: $47
Updated: 2025/07/31

TRC

Product number: D435835
Product name: 4,6-Dichloropyrimidine
Packaging: 10g
Price: $80
Updated: 2021/12/16

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4,6-Dichloropyrimidine Chemical Properties,Usage,Production

Uses

4,6-Dichloropyrimidine (cas# 1193-21-1) is a compound useful in organic synthesis.

Chemical Properties

Yellow Solid

Uses

4,6-Dichloropyrimidine was used in the synthesis of N-substituted azacalix[4]pyrimidines. It was used as starting reagent for the synthesis of disubstituted pyrimidines by tandem amination and Suzuki-Miyaura cross-coupling. It was also used in a biarylpyrimidine synthesis involving biaryl cross-coupling.

General Description

Cyclic voltammograms of 4,6-dichloropyrimidine shows three cathodic waves, arising from sequential cleavage of carbon-chlorine bonds as well as the reduction of pyrimidine.

Synthesis

The synthesis of 4,6-Dichloropyrimidine is as follows:Dissolve 105.5g of 4,6-diaminopyrimidine in 660.0g of 31% hydrochloric acid and pour into a 2000ml bottle to cool to -5 ° C and dropwise add 500.3g of 33% sodium nitrite. After 2 hours of reaction, HPLC detects 4,6-diamino Pyrimidine is less than 0.5%. 42.8 g of cuprous chloride and 214.0 g of 31% hydrochloric acid are prepared in a 2000 ml bottle. The diazonium salt mother liquor is added dropwise to the bottle. After the dropwise reaction, the reaction is performed at 45 ° C for 2 hours. .Extract with 400g of recovered trichloroethane (200x2 times less than new ones), combine the organic layers for distillation, control the water flush pump 5KPa, temperature 40-140 , collect 404.2g of solvent in the early 40-90 , 90-140 in the later The product was collected at a temperature of 14 ° C to obtain 146.9 g of 4,6-dichloropyrimidine. The yield was 86.4% (based on formazan hydrochloride) and the purity was 99.4%.

References

[1] Patent: CN108395409, 2018, A. Location in patent: Paragraph 0039-0041; 0044
[2] Patent: CN105439963, 2016, A. Location in patent: Paragraph 0011
[3] Patent: CN108341784, 2018, A. Location in patent: Paragraph 0027; 0028; 0029; 0031-0033; 0039; 0040
[4] Patent: CN105732514, 2016, A. Location in patent: Paragraph 0027; 0028
[5] Patent: CN108178749, 2018, A. Location in patent: Paragraph 0027; 0028; 0030; 0032; 0034; 0036; 0038; 0040

4,6-Dichloropyrimidine Preparation Products And Raw materials

Raw materials

4,6-Dihydroxypyrimidine Sodium ethoxide MALONIC ACID DI-N-BUTYL ESTER

Preparation Products

ETRIMFOS Bensulfuron methyl 2-Amino-4-Chloro-6-MethoxyPyrimidine 4,6-DIBROMOPYRIMIDINE 4-Hydroxy-6-aminopyrimidine 4-HYDRAZINO-6-HYDROXYPYRIMIDINE Chlorimuron-ethyl 2-Amino-4,6-dimethoxypyrimidine 6-Chloropyrimidin-4(3H)-one 5-BROMO-4,6-DIMETHOXYPYRIMIDINE

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View Lastest Price from 4,6-Dichloropyrimidine manufacturers

Shandong Jihui Chemical Co., Ltd.

Product: 4,6-Dichloropyrimidine 1193-21-1
Price: US $0.00-0.00/kg
Min. Order: 25kg
Purity: Purity: 99%
Supply Ability: 500tons
Release date: 2025-07-22

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4,6-Dichloropyrimidine 1193-21-1
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 1000KGS
Release date: 2021-06-28

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4,6-Dichloropyrimidine 1193-21-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-08

1193-21-1, 4,6-DichloropyrimidineRelated Search:

2-Amino-4-chloro-6-methoxypyrimidine Methyl (E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxyacrylate 4-Chloro-6-methyl-2-(methylthio)pyrimidine 5-amine-4,6-dichloropyrimidine,5-Amino-4,6-dichloropyrimidine, 98+% 4,6-DICHLORO-2-METHYLTHIO-5-PHENYLPYRIMIDINE 4,6-Dichloro-2-methyl-5-nitropyrimidine 2,4,6-Trichloro-5-methylpyrimidine 2,4,5,6-TETRACHLOROPYRIMIDINE 4,6-Dichloro-5-methoxypyrimidine 4,6-Dichloropyrimidine 4,6-Dichloro-5-nitropyrimidine 2-AMINO-4,6-DIHYDROXY-5-METHYLPYRIMIDINE 2,4,6-TRICHLORO-5-NITROPYRIMIDINE 4,6-Dichloro-2-methylpyrimidine 2-AMINO-4,6-DICHLOROPYRIMIDINE 95+%,2-AMINO-4,6-DICHLOROPYRIMIDINE 97+% 2,4-Dichloro-5-fluoropyrimidine 4,6-Dichloro-2-(methylthio)pyrimidine 2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

IFLAB-BB F2124-0077

PYRIMIDINE, 4,6-DICHLORO-

4 6-DICHLOROPYRIMIDINE 99%

4,6-Dichoropyrimidine

Pyrimidine, 4,6-dichloro- (7CI,8CI,9CI)

4,6-DICHLOROPYRIMIDINE

4,6-Dichloropyrimidine ,98%

4,6-Dichloropyrimidine,97%

4,6-Dichloropyridine

4,6-Dichloropyrimidi

4,6-Dichloro-1,3-diazine

4,6-DichloropyriMidine, 97% 5GR

NSC 37530

4,6-two chloropyriMidine

DichloropyriMidine

4,6-DichL

4,6-Dichlorpyrimidin

4.6-Dichloropyrimidine \/DCP

4,6-DIHYDROXY PYRIMIDINE 99+%

4,6-Dichloropyrimidine&gt

Cas 1193-21-1, 4,6-dichloropyrimidine

4,6-Dichloropyrimidine, 95%

1193-21-1

1193-21-2

Building Blocks

Pyrimidines

Heterocyclic Building Blocks

Halogenated Heterocycles

Bases & Related Reagents

Nucleotides

Pyrazines, Pyrimidines & Pyridazines

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

PyrimidinesHeterocyclic Building Blocks

Heterocycle-Pyrimidine series

alkyl chloride

Pyrimidines

Pyridines, Pyrimidines, Purines and Pteredines

PYRIMIDINE

FINE Chemical & INTERMEDIATES

Halides

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bc0001

1193-21-1