Uses
ChemicalBook > CAS DataBase List > 4,6-Dichloropyrimidine

4,6-Dichloropyrimidine

Uses
Product Name
4,6-Dichloropyrimidine
CAS No.
1193-21-1
Chemical Name
4,6-Dichloropyrimidine
Synonyms
NSC 37530;4,6-DichL;DichloropyriMidine;IFLAB-BB F2124-0077;4,6-Dichloropyrimidi;4,6-Dichloropyridine;4,6-Dichlorpyrimidin;4,6-Dichoropyrimidine;4,6-DICHLOROPYRIMIDINE;4,6-Dichloro-1,3-diazine
CBNumber
CB6473590
Molecular Formula
C4H2Cl2N2
Formula Weight
148.98
MOL File
1193-21-1.mol
More
Less

4,6-Dichloropyrimidine Property

Melting point:
65-67 °C (lit.)
Boiling point:
176 °C (lit.)
Density 
1.6445 (rough estimate)
vapor pressure 
30-390Pa at 20-50℃
refractive index 
1.6300 (estimate)
Flash point:
176°C
storage temp. 
Inert atmosphere,2-8°C
solubility 
95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to yellow
form 
Crystals
pka
-4.20±0.17(Predicted)
color 
Yellow-green
BRN 
111195
InChIKey
XJPZKYIHCLDXST-UHFFFAOYSA-N
LogP
1.45 at 25℃ and pH7.2
Surface tension
65.72mN/m at 1g/L and 20℃
CAS DataBase Reference
1193-21-1(CAS DataBase Reference)
NIST Chemistry Reference
Pyrimidine, 4,6-dichloro-(1193-21-1)
More
Less

Safety

Hazard Codes 
C
Risk Statements 
34-20/21/22-36/37
Safety Statements 
26-36/37/39-45-27
RIDADR 
UN 3263 8/PG 2
WGK Germany 
3
F 
19
Hazard Note 
Corrosive
HazardClass 
8
PackingGroup 
II
HS Code 
29335990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
145378
Product name
4,6-Dichloropyrimidine
Purity
97%
Packaging
10g
Price
$91.3
Updated
2024/03/01
Sigma-Aldrich
Product number
145378
Product name
4,6-Dichloropyrimidine
Purity
97%
Packaging
50g
Price
$126.8
Updated
2024/03/01
TCI Chemical
Product number
D2488
Product name
4,6-Dichloropyrimidine
Purity
>98.0%(GC)
Packaging
5g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
D2488
Product name
4,6-Dichloropyrimidine
Purity
>98.0%(GC)
Packaging
25g
Price
$44
Updated
2024/03/01
Alfa Aesar
Product number
L13212
Product name
4,6-Dichloropyrimidine, 98%
Packaging
25g
Price
$133.65
Updated
2024/03/01
More
Less

4,6-Dichloropyrimidine Chemical Properties,Usage,Production

Uses

4,6-Dichloropyrimidine (cas# 1193-21-1) is a compound useful in organic synthesis.

Chemical Properties

Yellow Solid

Uses

4,6-Dichloropyrimidine was used in the synthesis of N-substituted azacalix[4]pyrimidines. It was used as starting reagent for the synthesis of disubstituted pyrimidines by tandem amination and Suzuki-Miyaura cross-coupling. It was also used in a biarylpyrimidine synthesis involving biaryl cross-coupling.

General Description

Cyclic voltammograms of 4,6-dichloropyrimidine shows three cathodic waves, arising from sequential cleavage of carbon-chlorine bonds as well as the reduction of pyrimidine.

Synthesis

The synthesis of 4,6-Dichloropyrimidine is as follows:Dissolve 105.5g of 4,6-diaminopyrimidine in 660.0g of 31% hydrochloric acid and pour into a 2000ml bottle to cool to -5 ° C and dropwise add 500.3g of 33% sodium nitrite. After 2 hours of reaction, HPLC detects 4,6-diamino Pyrimidine is less than 0.5%. 42.8 g of cuprous chloride and 214.0 g of 31% hydrochloric acid are prepared in a 2000 ml bottle. The diazonium salt mother liquor is added dropwise to the bottle. After the dropwise reaction, the reaction is performed at 45 ° C for 2 hours. .Extract with 400g of recovered trichloroethane (200x2 times less than new ones), combine the organic layers for distillation, control the water flush pump 5KPa, temperature 40-140 , collect 404.2g of solvent in the early 40-90 , 90-140 in the later The product was collected at a temperature of 14 ° C to obtain 146.9 g of 4,6-dichloropyrimidine. The yield was 86.4% (based on formazan hydrochloride) and the purity was 99.4%.

4,6-Dichloropyrimidine Preparation Products And Raw materials

Raw materials

4,6-Dihydroxypyrimidine Sodium ethoxide MALONIC ACID DI-N-BUTYL ESTER

Preparation Products

ETRIMFOS Bensulfuron methyl 2-Amino-4-Chloro-6-MethoxyPyrimidine 4,6-DIBROMOPYRIMIDINE 4-Hydroxy-6-aminopyrimidine 4-HYDRAZINO-6-HYDROXYPYRIMIDINE Chlorimuron-ethyl 2-Amino-4,6-dimethoxypyrimidine 6-Chloropyrimidin-4(3H)-one 5-BROMO-4,6-DIMETHOXYPYRIMIDINE
More
Less

4,6-Dichloropyrimidine Suppliers

Americas 1 Belgium 1 Canada 3 China 538 Europe 4 Germany 7 India 16 Japan 3 Russia 1 Slovakia 1 South Korea 2 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 18 United States 60 Global 659
Zhejiang Aobang Pharmaceutical & Chemical Co. LTD
Tel
13676682222 13676682222
Email
877870302@qq.com
Country
China
ProdList
26
Advantage
58
Shanghai He Huan Chemical Co., Ltd.
Tel
021-60345187 13917602471
Fax
021-60345187
Email
lzz841106@aliyun.com
Country
China
ProdList
9908
Advantage
58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel
133-96369453 18678026865
Fax
0536-2101172
Email
sdfantai@163.com
Country
China
ProdList
852
Advantage
58
ELSA BIOTECHNOLOGY CO.,LTD.
Tel
15261860116
Fax
86-025-84106591
Email
sales@elsa-biotech.com
Country
China
ProdList
99
Advantage
55
Weifang Siyuan Chemical Co., Ltd.
Tel
0536-8888106 17663601818
Fax
0536-8888106
Email
2354379876@qq.com
Country
China
ProdList
244
Advantage
58
Weifang Mingran Chemical Co., Ltd.
Tel
15066331899,0536-2082396,117761326 15063661899
Fax
0536-2082397
Email
mingranchem@163.com
Country
China
ProdList
430
Advantage
58
Weifang Yuan Ye Biotechnology Co., Ltd.
Tel
0536-5316600 15684478666
Fax
0536-5396089
Email
shan@yuanyechemical.com
Country
China
ProdList
41
Advantage
58
Changzhou Gangtong Chemical Co., Ltd
Tel
13506120961
Email
1871415438@163.com
Country
China
ProdList
25
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2210
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94838
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1998
Advantage
65
ChemFuture PharmaTech (Jiangsu) Ltd
Tel
5108538618
Fax
86 510 85386988-8017
Email
suger.wang@chemfuture.com
Country
China
ProdList
822
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820 13031183356
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1392
Advantage
62
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35906
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12426
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9551
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11660
Advantage
64
ZEROSCHEM.CO.,LTD.
Tel
10-61256048 13810278579
Fax
+86 10 61256049
Email
sales@zeroschem.com
Country
China
ProdList
1316
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
17939
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5700
Advantage
66
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
Advantage
52
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3296
Advantage
57
Shandong Xiya Chemical Co., Ltd
Tel
13355009207 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18739
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Wuhan Kemi-Works Chemical Co., Ltd
Tel
027-85736489
Fax
86-27-85736485
Email
info@kemiworks.net
Country
China
ProdList
542
Advantage
57
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
+8618575662672 18575662672
Fax
021 51613951
Email
mzeng@3wpharm.com
Country
China
ProdList
10070
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11714
Advantage
57
ZhengZhou HuaWen Chemical Co.Ltd
Tel
0370-2785118 15343847665
Fax
QQ：3470079902
Email
huawenchem@163.com
Country
China
ProdList
3206
Advantage
55
Beijing Taiya Jie Technology Development Co., Ltd.
Tel
021-33690831-8001 13552411790
Fax
021-33690831
Email
postmaster@tyjchem.cn
Country
China
ProdList
1542
Advantage
55
Shanghai Nuohey Chemical Co., Ltd.
Tel
021-52212593 13761626812
Fax
+86 (21) 51062076
Email
sales@nuohey.com
Country
China
ProdList
10692
Advantage
60
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4941
Advantage
60
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6139
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6181
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9901
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
13901585132
Fax
+86-25-52131256
Email
799750417@qq.com
Country
China
ProdList
8888
Advantage
55
More
Less

View Lastest Price from 4,6-Dichloropyrimidine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
4,6-Dichloropyrimidine 1193-21-1
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000KGS
Release date
2021-06-28
Anhui Yisheng Technology Co., LTD
Product
4,6-dichloropyrimidine 1193-21-1
Price
US $140.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
2000 KG
Release date
2023-01-06
Shaanxi Didu New Materials Co. Ltd
Product
4,6-Dichloropyrimidine 1193-21-1
Price
US $1.50/g
Min. Order
1g
Purity
99.0% Min
Supply Ability
100 Tons
Release date
2022-09-19

1193-21-1, 4,6-DichloropyrimidineRelated Search:

2-Amino-4-chloro-6-methoxypyrimidine Methyl (E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxyacrylate 4-Chloro-6-methyl-2-(methylthio)pyrimidine 5-amine-4,6-dichloropyrimidine,5-Amino-4,6-dichloropyrimidine, 98+% 4,6-DICHLORO-2-METHYLTHIO-5-PHENYLPYRIMIDINE 4,6-Dichloro-2-methyl-5-nitropyrimidine 2,4,6-Trichloro-5-methylpyrimidine 2,4,5,6-TETRACHLOROPYRIMIDINE 4,6-Dichloro-5-methoxypyrimidine 4,6-Dichloropyrimidine 4,6-Dichloro-5-nitropyrimidine 2-AMINO-4,6-DIHYDROXY-5-METHYLPYRIMIDINE 2,4,6-TRICHLORO-5-NITROPYRIMIDINE 4,6-Dichloro-2-methylpyrimidine 2-AMINO-4,6-DICHLOROPYRIMIDINE 95+%,2-AMINO-4,6-DICHLOROPYRIMIDINE 97+% 2,4-Dichloro-5-fluoropyrimidine 4,6-Dichloro-2-(methylthio)pyrimidine 2,5-Diamino-4,6-dihydroxypyrimidine hydrochloride

  • IFLAB-BB F2124-0077
  • PYRIMIDINE, 4,6-DICHLORO-
  • 4 6-DICHLOROPYRIMIDINE 99%
  • 4,6-Dichoropyrimidine
  • Pyrimidine, 4,6-dichloro- (7CI,8CI,9CI)
  • 4,6-DICHLOROPYRIMIDINE
  • 4,6-Dichloropyrimidine ,98%
  • 4,6-Dichloropyrimidine,97%
  • 4,6-Dichloropyridine
  • 4,6-Dichloropyrimidi
  • 4,6-Dichloro-1,3-diazine
  • 4,6-DichloropyriMidine, 97% 5GR
  • NSC 37530
  • 4,6-two chloropyriMidine
  • DichloropyriMidine
  • 4,6-DichL
  • 4,6-Dichlorpyrimidin
  • 4.6-Dichloropyrimidine \/DCP
  • 4,6-DIHYDROXY PYRIMIDINE 99+%
  • 4,6-Dichloropyrimidine&gt
  • Cas 1193-21-1, 4,6-dichloropyrimidine
  • 1193-21-1
  • 1193-21-2
  • Building Blocks
  • Pyrimidines
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Bases & Related Reagents
  • Nucleotides
  • Pyrazines, Pyrimidines & Pyridazines
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • PyrimidinesHeterocyclic Building Blocks
  • Heterocycle-Pyrimidine series
  • alkyl chloride
  • Pyrimidines
  • Pyridines, Pyrimidines, Purines and Pteredines
  • PYRIMIDINE
  • FINE Chemical & INTERMEDIATES
  • Halides
  • Heterocycles
  • Pyrazines, Pyrimidines & Pyridazines
  • Nucleotides and Nucleosides
  • J's
  • bc0001
  • 1193-21-1