1-Benzothiophen-5-amine
- Product Name
- 1-Benzothiophen-5-amine
- CAS No.
- 20532-28-9
- Chemical Name
- 1-Benzothiophen-5-amine
- Synonyms
- benzo[b]thiophen-5-amine;IFLAB-BB F0817-0001;5-Aminobenzothiophen;5-Aminothionaphthene;benzothiophen-5-amine;5-AMINOBENZOTHIOPHENE;1-BENZOTHIOPHEN-5-AMINE;5-Benzo[b]thiophenamine;5-Aminobenzo[b]thiophene;5-Aminebenzo[b]thiophene
- CBNumber
- CB7233401
- Molecular Formula
- C8H7NS
- Formula Weight
- 149.21
- MOL File
- 20532-28-9.mol
1-Benzothiophen-5-amine Property
- Melting point:
- 72 °C
- Boiling point:
- 313.1±15.0 °C(Predicted)
- Density
- 1.294±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- solid
- pka
- 4.10±0.10(Predicted)
- color
- Light brown to brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B276753
- Product name
- Benzo[b]thiophen-5-amine
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- FA147536
- Product name
- 5-Aminobenzothiophene
- Packaging
- 500mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- FA147536
- Product name
- 5-Aminobenzothiophene
- Packaging
- 1g
- Price
- $242
- Updated
- 2021/12/16
- Product number
- FA147536
- Product name
- 5-Aminobenzothiophene
- Packaging
- 2g
- Price
- $421
- Updated
- 2021/12/16
- Product number
- OR47828
- Product name
- 5-Aminobenzo[b]thiophene
- Packaging
- 250mg
- Price
- $31
- Updated
- 2021/12/16
1-Benzothiophen-5-amine Chemical Properties,Usage,Production
Definition
ChEBI: 1-Benzothiophen-5-amine is a member of 1-benzothiophenes.
Synthesis
4965-26-8
20532-28-9
General procedure for the synthesis of 5-aminobenzo[b]thiophene from 5-nitrobenzo[b]thiophene: A mixture of 5-nitrobenzo[b]thiophene (3.09 g, 17.0 mmol) with 10% palladium carbon catalyst (Aldrich, Catalog No. 20,569-9) (150 mg) in ethanol (90 mL) was placed in a Parr reaction flask. The hydrogenation reaction was carried out under hydrogen atmosphere at 3 bar with continuous shaking for 16 hours. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filter cake was washed with ethanol (2 x 30 mL). The combined filtrates were concentrated under reduced pressure to afford benzo[b]thiophen-5-amine (2.57 g, 100% yield) as a dark purple amorphous solid. Its 1H NMR (CDCl3, 400 MHz) data were as follows: δ 3.70 (broad single peak, 2H), 6.78 (double peak, J = 8.61, 1.96 Hz, 1H), 7.10 (double peak, J = 2.35 Hz, 1H), 7.14 (double peak, J = 5.09 Hz, 1H), 7.38 (double peak, J = 5.48 Hz, 1H), and 7.63 (double peak, J = 8.61 Hz, 1H).
References
[1] Patent: WO2006/66172, 2006, A1. Location in patent: Page/Page column 27
[2] Synthetic Communications, 1991, vol. 21, # 7, p. 959 - 964
[3] Journal of Medicinal Chemistry, 2002, vol. 45, # 19, p. 4128 - 4139
[4] Proceedings - Indian Academy of Sciences, Section A, 1952, # 36, p. 405,408
[5] Journal of the American Chemical Society, 1955, vol. 77, p. 5939,5943
1-Benzothiophen-5-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Benzothiophen-5-amine manufacturers
- Product
- 1-Benzothiophen-5-amine 20532-28-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- G/KG/T
- Release date
- 2019-12-24