Description
ChemicalBook > CAS DataBase List > Methyl cyanoacetate

Methyl cyanoacetate

Description
Product Name
Methyl cyanoacetate
CAS No.
105-34-0
Chemical Name
Methyl cyanoacetate
Synonyms
Methyl 2-cyanoacetate;2-cyanopropanoate;CYANOACETIC ACID METHYL ESTER;MCYA;usafkf-22;USAF kf-22;25KG,100KG,1T;Methylcyanacetat;METHYL CYANOACETATE;MetthylCyanoacetate
CBNumber
CB9485583
Molecular Formula
C4H5NO2
Formula Weight
99.09
MOL File
105-34-0.mol
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Methyl cyanoacetate Property

Melting point:
-13 °C
Boiling point:
204-207 °C(lit.)
Density 
1.123 g/mL at 25 °C(lit.)
vapor density 
3.41 (vs air)
vapor pressure 
0.2 mm Hg ( 20 °C)
refractive index 
n20/D 1.417(lit.)
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
54g/l
form 
Liquid
pka
2.75±0.10(Predicted)
color 
Clear colorless to very slightly yellow
Water Solubility 
54 g/L (20 ºC)
Sensitive 
Light Sensitive
BRN 
773945
Dielectric constant
29.4(21℃)
LogP
-0.47 at 25℃
CAS DataBase Reference
105-34-0(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, cyano-, methyl ester(105-34-0)
EPA Substance Registry System
Acetic acid, cyano-, methyl ester (105-34-0)
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Safety

Hazard Codes 
Xi
Safety Statements 
24/25
WGK Germany 
1
RTECS 
AG4375000
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29269095
Toxicity
guinea pig,LDLo,skin,400mg/kg (400mg/kg),"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 920, 1986.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
108421
Product name
Methyl cyanoacetate
Purity
99%
Packaging
25g
Price
$57.4
Updated
2024/03/01
Sigma-Aldrich
Product number
108421
Product name
Methyl cyanoacetate
Purity
99%
Packaging
2kg
Price
$209
Updated
2023/06/20
TCI Chemical
Product number
C0442
Product name
Methyl Cyanoacetate
Purity
>99.0%(GC)
Packaging
25mL
Price
$34
Updated
2024/03/01
TCI Chemical
Product number
C0442
Product name
Methyl Cyanoacetate
Purity
>99.0%(GC)
Packaging
500mL
Price
$75
Updated
2024/03/01
Alfa Aesar
Product number
A15555
Product name
Methyl cyanoacetate, 99%
Packaging
250g
Price
$43.2
Updated
2024/03/01
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Methyl cyanoacetate Chemical Properties,Usage,Production

Description

Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds. It is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate; a compound used in the synthesis of DPP-IV inhibitors for treating type-2 diabetes. In addition, it is an intermediate in the preparation of α-cyanoacrylate, malononitrile, and 1,1-cyclohexanediacetic acid dyes. It is used as UV absorber or stabilizer, intermediate for pharmaceuticals. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds.

Chemical Properties

clear colorless to very slighlty yellow liquid

Uses

pharmaceutical intermediate

Uses

Methyl cyanoacetate is an intermediate in the preparation of α-cyanoacrylate, malononitrile, 1,1-cyclohexanediacetic acid dye. It is used as UV absorber or stabiliser, intermediate for pharmaceuticals. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds.

Definition

ChEBI: Methyl cyanoacetate is an alkyl cyanoacetate ester.

General Description

Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Kn?venagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α-cyanocinnamic esters.

Purification Methods

Purify the ester by shaking with 10% Na2CO3 solution, wash well with water, dry with anhydrous Na2SO4, and distil it. [Beilstein 2 H 584, 2 I 253, 2 II 530, 2 III 1628, 2 IV 1889.]

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Methyl cyanoacetate Suppliers

Shanghai ideal Industrial Co., Ltd.
Tel
021-58957966 18930537195
Fax
021-60899437
Email
wouchina@126.com
Country
China
ProdList
3027
Advantage
58
Nanjing Yihua Biotechnology Co., Ltd
Tel
15952064210
Email
184982398@qq.com
Country
China
ProdList
296
Advantage
58
Weifang Siyuan Chemical Co., Ltd.
Tel
0536-8888106 17663601818
Fax
0536-8888106
Email
2354379876@qq.com
Country
China
ProdList
245
Advantage
58
Shandong Deju Renhe chemical raw materials Co., Ltd
Tel
15253208962
Email
sddjrhhgyl@126.com
Country
China
ProdList
664
Advantage
58
Shandong Xibang Biological Technology Development Co. LTD
Tel
0536-3611186 15063661551
Fax
0536-3611186
Email
196056703@qq.com
Country
China
ProdList
50
Advantage
58
Creasyn Finechem(Tianjin) Co., Ltd.
Tel
022-83946278 13820503911
Fax
022-83945176
Email
sales@creasyn.com
Country
China
ProdList
970
Advantage
68
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
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View Lastest Price from Methyl cyanoacetate manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
Methyl Cyanoacetate 105-34-0
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-12
Hebei Weibang Biotechnology Co., Ltd
Product
Methyl cyanoacetate 105-34-0
Price
US $1.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-05-26
Weijer International Trade (Hebei) Co., Ltd
Product
Methyl cyanoacetate 105-34-0
Price
US $1.00/KG
Min. Order
1KG
Purity
>99%
Supply Ability
3000T
Release date
2023-03-20

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