ChemicalBook > CAS DataBase List > 2,4-Diamino-6-hydroxypyrimidine

2,4-Diamino-6-hydroxypyrimidine

Product Name
2,4-Diamino-6-hydroxypyrimidine
CAS No.
56-06-4
Chemical Name
2,4-Diamino-6-hydroxypyrimidine
Synonyms
1956-6-4;2,6-DIAMINOPYRIMIDIN-4-OL;DAHP;2,6-Diaminopyrimidin-4(1H)-one;2,6-DIAMINO-4-PYRIMIDINOL;2,6-diamino-1H-pyrimidin-4-one;2,6-DIAMINO-4-HYDROXYPYRIMIDINE;4(3H)-pyrimidinone, 2,6-diamino-;9-60-9;NSC 9302
CBNumber
CB0174912
Molecular Formula
C4H6N4O
Formula Weight
126.12
MOL File
56-06-4.mol
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2,4-Diamino-6-hydroxypyrimidine Property

Melting point:
285-286 °C (dec.) (lit.)
Boiling point:
234.22°C (rough estimate)
Density 
1.3659 (rough estimate)
refractive index 
1.7990 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
10.61±0.50(Predicted)
form 
Fine Crystalline Powder
color 
White to cream
Sensitive 
Light Sensitive
Merck 
14,2981
BRN 
125006
InChIKey
SWELIMKTDYHAOY-UHFFFAOYSA-N
CAS DataBase Reference
56-06-4(CAS DataBase Reference)
NIST Chemistry Reference
4(1H)-pyrimidinone, 2,6-diamino-(56-06-4)
EPA Substance Registry System
2,6-Diamino-4(1H)-pyrimidinone (56-06-4)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29335995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D1321
Product name
2,4-Diamino-6-hydroxypyrimidine
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$76
Updated
2025/07/31
Cayman Chemical
Product number
81260
Product name
2,4-Diamino-6-hydroxypyrimidine
Purity
≥98%
Packaging
1g
Price
$26
Updated
2024/03/01
Cayman Chemical
Product number
81260
Product name
2,4-Diamino-6-hydroxypyrimidine
Purity
≥98%
Packaging
5g
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
81260
Product name
2,4-Diamino-6-hydroxypyrimidine
Purity
≥98%
Packaging
10g
Price
$74
Updated
2024/03/01
Cayman Chemical
Product number
81260
Product name
2,4-Diamino-6-hydroxypyrimidine
Purity
≥98%
Packaging
25g
Price
$93
Updated
2024/03/01
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2,4-Diamino-6-hydroxypyrimidine Chemical Properties,Usage,Production

Description

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.

Chemical Properties

White Solid

Uses

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.[Cayman Chemical]

Uses

2,4-Diamino-6-hydroxypyrimidine (cas# 56-06-4) is a compound useful in organic synthesis.

Uses

It stands at the beginning of the enzyme-catalyzed cascade that starts with this seven-carbon carbohydrate and ends with the aromatic amino acids phenylalanine, tyrosine, and tryptophan

Synthesis

A solution of sodium ethoxide is prepared from 23 g. (1 g. atom) of sodium and 250 ml of anhydrous ethanol in a 1-l round-bottomed flask fitted with a reflux condenser carrying a calcium chloride drying tube. After the sodium has dissolved, the solution is cooled and 113 g. (1 mole) of ethyl cyanoacetate is added. This mixture is allowed to stand while a second solution of sodium ethoxide of the same volume and concentration is prepared. To this solution is added 97 g. (1.02 moles) of guanidine hydrochloride. The sodium chloride is separated by filtration, and the clear filtrate containing guanidine is added to the solution of ethyl sodiocyanoacetate. This mixture is heated for 2 hours under reflux and is then evaporated to dryness at atmospheric pressure. The solid product is dissolved in 325 ml. of boiling water and acidified with 67 ml. of glacial acetic acid. Upon cooling of the solution, 101–103 g. (80–82%) of yellow needles separates; m.p. 260–270° (dec.)

storage

+4°C

Purification Methods

2,4-Diamino-6-hydroxypyrimidine recrystallises from H2O. [Beilstein 25 III/IV 3642.]

References

[1] Patent: CN107857734, 2018, A. Location in patent: Paragraph 0032; 0033; 0034; 0035

2,4-Diamino-6-hydroxypyrimidine Preparation Products And Raw materials

Raw materials

Guanidine nitrate Methyl cyanoacetate

Preparation Products

2,4-DIAMINO-6-MERCAPTOPYRIMIDINE 2,6-DIAMINO-4-METHOXY PYRIMIDINE
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2,4-Diamino-6-hydroxypyrimidine Suppliers

Americas 1 Austria 1 Belgium 3 Canada 2 China 381 Europe 5 France 3 Germany 11 India 50 Italy 1 Japan 6 Russia 2 Slovakia 1 South Korea 2 Switzerland 4 The Netherlands 3 Ukraine 2 United Kingdom 22 United States 65 USA 1 Global 566
Jinan Sanyuan Chemical Co. LTD
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0531-58582194; 18615587029
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0531-58585914
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1660423085@qq.com
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China
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Shanghai TongYuan Chemical Co., Ltd.
Tel
021-021-69182866 13701855675
Fax
021-69182022
Email
tongyuanchem@126.com
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China
ProdList
4192
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Hunan HuaTeng Pharmaceutical Co., Ltd.,
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400-8592883
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0731-82251112
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sales@huatengsci.com
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China
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Jilin Lianben Technology Development Co., Ltd
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0432-62601618 13756693631
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0432-62601618
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wangjiaqi@lianben.com
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China
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Hubei DAHAO Chemical Co., Ltd.
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027-59106191 13986034860
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1400828855@qq.com
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China
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Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
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13396369453 QQ3007939906 18678026865
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0536-2101172
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sdfantai@163.com
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China
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SiChuang NanBu Honesty Technology Co., Ltd.
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0838-5675166 15883665058
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0838-5675535
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nbcxkj@126.com
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China
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J & K SCIENTIFIC LTD.
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18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-021-61259138 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
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China
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40228
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INTATRADE GmbH
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+49 3493/605464
Fax
+49 3493/605470
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sales@intatrade.de
Country
Germany
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View Lastest Price from 2,4-Diamino-6-hydroxypyrimidine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2,4-Diamino-6-hydroxypyrimidine 56-06-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-31
Anhui Ruihan Technology Co., Ltd
Product
2,4-Diamino-6-hydroxypyrimidine 56-06-4
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000t/year
Release date
2023-09-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
2,4-Diamino-6-hydroxypyrimidine 56-06-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

56-06-4, 2,4-Diamino-6-hydroxypyrimidineRelated Search:

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  • TIMTEC-BB SBB004252
  • 2,4-DIAMINOPYRIMIDIN-6-OL
  • 2,4-DIAMINO-6-HYDROXYPYRIMIDINE
  • 2,4-DIAMINO-6-PYRIMIDINOL
  • 2,4-DIAMINO-6(1H)-PYRIMIDINONE
  • 2,6-DIAMINO-4-PYRIMIDINOL
  • 2,6-DIAMINO-4-PYRIMIDINONE
  • 2,6-DIAMINOPYRIMIDIN-4-OL
  • 2,6-DIAMINO-4(1H)-PYRIMIDINONE
  • 2,6-DIAMINO-4-HYDROXYPYRIMIDINE
  • AURORA KA-376
  • DAHP
  • AKOS MSC-0109
  • 2,6-Diamino-4-Hydroxyprimidine
  • 2,6-diamino-1H-pyrimidin-4-one
  • 2-4-DIAMINO6HYDROXY PYRIMID
  • 2,4- two-6- aMinohydroxy pyriMidine
  • 2,4-DiaMino-6-hydroxypyriMidine 96%
  • 2,4-DiaMino-6-hydroxypyriMidine, 97+%
  • 3-methylidene-1,5-benzodioxepine
  • Pemetrexed Impurity 16
  • 4(3H)-pyrimidinone, 2,6-diamino-
  • InChI=1/C4H6N4O/c5-2-1-3(9)8-4(6)7-2/h1H,(H5,5,6,7,8,9
  • 1956-6-4
  • 2,4-Diamino-6-hydroxypyrimidiine
  • 4(1H)-Pyrimidinone, 2,6-diamino- (8CI,9CI)
  • 2,6-Diaminopyrimidin-4-one
  • 6-Aminoisocytosine
  • NSC 44914
  • NSC 680818
  • NSC 9302
  • 2,4-Diamino-6-hydroxy
  • 2,4-diaminohypoxanthine
  • 2,6-Diamino-1H-pyrimidin-4-on
  • 2,4-Diamino-6. -Hydroxypyimidine
  • 2,6-DIAMINO-3H-PYRIMIDIN-4-ONE
  • 4(1H)-Pyrimidinone, 2,6-diamino
  • 2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol, 2,6-Diamino-4-pyrimidinone
  • 2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol
  • 2,4-Diamino-6-pyrimidinone
  • 2,6-Diamino-3,4-dihydropyrimidine-4-one
  • 2,6-Diamino-4(3H)-pyrimidinone
  • 2,6-Diaminopyrimidin-4(1H)-one
  • 2,4-Diamino-6-hydroxypyrimidine,2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol, 2,6-Diamino-4-pyrimidinone
  • 4-DiaMino-6-hydroxypyriMidine
  • 2,4-Diamino-6-hydroxypyrimidine,96%
  • 2,4-DIAMINO-6-HYDROXYPYRIDIMIDINE
  • 6-Hydroxy-2,4-diaminopyrimidine
  • 2,4-Diamino-6-hydroxypyrimidine &gt
  • 2,4-Diamino-6-hydroxypyrimidine ISO 9001：2015 REACH
  • 2,4-Diamino-6-hydroxypyrimidine,56-06-4
  • NSC 18522
  • NSC18522
  • NSC-18522
  • Minoxidil Impurity 19
  • 2,4-Diamino-6-hydroxypyrimidine(98.60%)
  • 9-60-9
  • 2.4-Diamino-6-pyrimidone