4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid

Product Name: 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid
CAS No.: 137281-39-1
Chemical Name: 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid
Synonyms: 4-(2-(2-AMino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzoic acid;Pemetrexed Intermediate Benzoic Acid;4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid;]-benzoic acid;US-DMF No.: 031215;4-[2-(2-Amino-4,7-di;Pemetrexed Impurity 7;PeMetrexed IMpurity A;Pemetrexed Impurity 11;o[2,3-d]pyrimidin-5-yL
CBNumber: CB11012504
Molecular Formula: C15H14N4O3
Formula Weight: 298.3
MOL File: 137281-39-1.mol

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4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid Property

Melting point:: >270°C (dec.)
Density: 1.55±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 4.30±0.10(Predicted)
color: White to Pale Pink
InChI: InChI=1S/C15H14N4O3/c16-15-18-12-11(13(20)19-15)10(7-17-12)6-3-8-1-4-9(5-2-8)14(21)22/h1-2,4-5,7H,3,6H2,(H,21,22)(H4,16,17,18,19,20)
InChIKey: AIZPFZIKHIJCQX-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=C(CCC2C3C(=O)NC(N)=NC=3NC=2)C=C1
CAS DataBase Reference: 137281-39-1(CAS DataBase Reference)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2618
Product name: 4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid Hydrate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $35
Updated: 2026/03/19

TCI Chemical

Product number: A2618
Product name: 4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid Hydrate
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $139
Updated: 2026/03/19

TRC

Product number: A604905
Product name: 4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoicAcid
Packaging: 50mg
Price: $120
Updated: 2021/12/16

TRC

Product number: A604905
Product name: 4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoicAcid
Packaging: 1g
Price: $340
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0002195
Product name: 4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)ETHYL]-BENZOIC ACID
Purity: 95.00%
Packaging: 25MG
Price: $704.55
Updated: 2021/12/16

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4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid Chemical Properties,Usage,Production

Description

4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid, as key intermediates of pemetrexed disodium, is used in the synthesis of antitumor drugs and is also an important chemical building block in drug development and analysis. Pemetrexed disodium is a multi-target antifolate metabolism antitumor drug, clinically used to treat diseases such as non-small cell lung cancer and malignant pleural mesothelioma.

Chemical Properties

Pale Pink Solid

Uses

Pemetrexed intermediate

Synthesis

Methyl 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoate was obtained from the dehydration condensation of its corresponding 2,4-diamino-6-hydroxypyrimidine and corresponding 2-bromoaldehyde under certain conditions, and the ester product obtained was hydrolyzed to carboxylic acid under alkaline conditions to obtain 4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3]pyrimidin-5-yl)ethyl]benzoic acid. 4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3]pyrimidin-5-yl)ethyl]benzoic acid.

4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid Suppliers

Americas 1 Canada 3 China 301 Europe 1 France 1 Germany 3 India 48 Japan 1 Ukraine 1 United Kingdom 6 United States 29 Global 395

Shandong Platinum Pharmaceutical Co., Ltd.

Tel: 0531-88977029 18396830603
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Email: sales@boyuanpharm.com
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J & K SCIENTIFIC LTD.

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Fax: 86-10-82849933
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
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Ark Pharm, Inc.

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Adamas Reagent, Ltd.

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Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
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Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
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XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527621225; 15527621225
Email: 1791901229@qq.com
Country: China
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Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
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ProdList: 3295
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View Lastest Price from 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid 137281-39-1
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 1000kg
Release date: 2021-11-09

Hebei Dangtong Import and export Co LTD

Product: 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid 137281-39-1
Price: US $60.00/kilograms
Min. Order: 100kilograms
Purity: 99%
Supply Ability: 100tons
Release date: 2023-03-01

Hangzhou ICH Biofarm Co., Ltd

Product: Pemetrexed disodium INT-4 137281-39-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.0%min
Supply Ability: 5MT
Release date: 2023-06-14

137281-39-1, 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acidRelated Search:

Pemetrexed Disodium Heptahydrate 3-Buten-1-ol Lithium bis(trimethylsilyl)amide Methyl 4-(4-hydroxybut-1-ynyl)benzoate Pemetrexed Impurity 17 Methyl 4-(4-hydroxybutyl)benzoate Pemetrexed Impurity 11 3-Butyn-1-ol N-[4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMic Acid Methyl 4-(4-oxobutyl)benzoate N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester Gemcitabine hydrochloride Pemetrexed Disodium Pemetrexed disodium hemipentahydrate 4-[2’-(7’’-Deazaguanine)ethyl]benzoic Acid N-Hydroxysuccinimide Ester 2,4-Diamino-6-hydroxypyrimidine N-[4-[3-(2,6-DiaMino-1,4-dihydro-4-oxo-5-pyriMidinyl)-3-oxopropyl]benzoyl]-L-glutaMic Acid PeMetrexed IMpurity D

4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoic acid (intermediate of pemetrexed)

4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-1H-PYMOL[2,3-D]PYRIMODIN-5-YL)ETHYL]BENZOIC ACID

4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid

4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-Benzoic Acid

4-[2-（2-Amino-4-oxo-4,7- Dihydro-3H-pyrrolo[2,3-d]pyrimidine -5-yl）ethyl]benzoic acid

Pemetrexed reference substance

Benzoic acid, 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]- (9CI)

Pemetrexed Intermediate Benzoic Acid

Pemetrexed acid intermediate

4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)

Pemetrexed disodium intermediate

Pemetrexed Intermediate

4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid

Pemetrexed Impurity 11

4-(2-(2-amino-4,7-dihydro-4-oxo-1h-pyrrol(2,3-d)pyrimidin-5-yl)ethyl)benzoic acid

pymol-[2,3-d]pyrimidin-5-yl) ethyl]

4-[2-(2-Amino-4,7-dihydro-4-oxo-3<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-5-yl)ethyl]benzoic Acid Hydrate

Pemetrexed Impurity 7

4-[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]benzoic acid ,98%

4-[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoic acid ,99%

4-[2-(2-Amino-4,7-di

4-[2-(-AMino-4,7-dihydro-4-oxo-1H-pyMol[2,3-d]pyriModin-5-yl)ethyl]benzoic acid

4-(2-{2-aMino-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyriMidin-5-yl}ethyl)benzoic acid

4-(2-(2-AMino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzoic acid

4-[2-(2-AMino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoic Acid Hydrate

d pyriModin -5-yl)ethyl benzoic acid

PeMetrexed IMpurity A

4- 2-(2-AMino-4,7-dihydro-4-oxo-1H-pyrrolo 2...

PeMetrexed disodiuM INT-4

Benzoic acid,4-[2-(2-aMino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]-

Pemetrexed Intermediate(PMC)

4[2-(2-amino-4,7-dihydro-4-oxo-1H-pymol [2,3-pyrimodin-5-yl]ethyl) benzoic acid

4-(2-(2-amino-4-oxo-4,7-dihydro-

Pemetrexed disodium Impurity 13

4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid Hydrate&gt

4-[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrroL

o[2,3-d]pyrimidin-5-yL

]-benzoic acid

2-Amino-4,7-dihydro-5-[2-[4-(carboxy)phenyl]ethyl]-4-oxo-3H-pyrrolo[2,3-d]pyrimidine

4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-y...

US-DMF No.: 031215

4 - [2 - (2-amino-4,7-dihydro-4-ox-1H-pyrrole [2,3-D] pyrimidin-5-yl) ethyl] benzoic acid

4-[2-(2-Amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid

4- [2- (2-amino-4,7-dihydro-4-oxo-3H-pyrrolo [2,3] pyrimidin-5-yl) ethyl] benzoic acid

4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid Hydrate, ≥ 98.0%

4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl] (ABA) , 99%min

4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid (Pemetrexed Impurity)

137281-39-1

4-137281-39-1

C15H14N4O3xH2O

Intermediates

Intermediates & Fine Chemicals

Pharmaceuticals

Organic acids

PEMETREXED DISODIUM

(intermediate of pemetrexed)

Various Intermediates