ChemicalBook > CAS DataBase List > N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester

Product Name
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester
CAS No.
146943-43-3
Chemical Name
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester
Synonyms
Famitinib Impurity 2;PeMetrexed Diethyl Ester;Pemetrexed Impurity 20(Pemetrexed Diethyl Ester);(S)-Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,...;Diethyl N-[4-{2-(2-amino-4-hydroxypyrrolo[2,3-d]pyrimidin-5-yl)ethyl}-benzoyl]-L-glutamate;(S)-Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate;N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester;N-{4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-EL)ETHYL]BENZOYL}-L-GLUTAMIC?ACID?1,5-DIETHYL?ESTER;L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, 1,5-diethyl ester;N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester USP/EP/BP
CBNumber
CB62462080
Molecular Formula
C24H29N5O6
Formula Weight
483.52
MOL File
146943-43-3.mol
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N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester Property

Melting point:
84-86 ºC
Density 
1.38
storage temp. 
Refrigerator
solubility 
DMSO, Methanol (Slightly)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
P219510
Product name
PemetrexedDiethylEster
Packaging
50mg
Price
$1190
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
66647
Product name
PemetrexedDiethylEster
Packaging
50mg
Price
$2200
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA151584
Product name
(S)-2-(4-[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino)-pentanedioicacid diethylester
Packaging
2mg
Price
$59
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA151584
Product name
(S)-2-(4-[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino)-pentanedioicacid diethylester
Packaging
5mg
Price
$118
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA151584
Product name
(S)-2-(4-[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethyl]-benzoylamino)-pentanedioicacid diethylester
Packaging
10mg
Price
$205
Updated
2021/12/16
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N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester Chemical Properties,Usage,Production

Uses

Pemetrexed Diethyl Ester is an protected intermediate in the synthesis of Pemetrexed (P219500), an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes.

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester Suppliers

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146943-43-3, N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl esterRelated Search:

Methyl 4-bromobenzoate Pemetrexed Disodium LY 338979 DiMethyl Ester but-3-en-1-yl 4-methylbenzene-1-sulfonate PeMetrexed IMpurity D 2,4-Diamino-6-hydroxypyrimidine Pemetrexed Disodium Heptahydrate P219490 4-(4-Hydroxybutyl)benzoic acid Methyl ester Pemetrexed Impurity 18 5-BroMopyriMidine-2,4,6(1H,3H,5H)-trione 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid methyl ester 3-Buten-1-ol 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid N-[4-[3-(2,6-DiaMino-1,4-dihydro-4-oxo-5-pyriMidinyl)-3-oxopropyl]benzoyl]-L-glutaMic Acid 4-[2’-(7’’-Deazaguanine)ethyl]benzoic Acid N-Hydroxysuccinimide Ester Methyl 4-(4-oxobutyl)benzoate Methyl 4-(4-hydroxybut-1-ynyl)benzoate

  • N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester
  • (S)-Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate
  • PeMetrexed diethyl ester (L-GlutaMic acid, N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-, 1,5-diethyl ester )
  • PeMetrexed Diethyl Ester
  • Pemetrexed Impurity 20(Pemetrexed Diethyl Ester)
  • L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, 1,5-diethyl ester
  • N-{4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-EL)ETHYL]BENZOYL}-L-GLUTAMIC?ACID?1,5-DIETHYL?ESTER
  • N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester USP/EP/BP
  • (S)-Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,...
  • (S)-Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate? (Pemetrexed Disodium Impurity)
  • Famitinib Impurity 2
  • Diethyl N-[4-{2-(2-amino-4-hydroxypyrrolo[2,3-d]pyrimidin-5-yl)ethyl}-benzoyl]-L-glutamate
  • 146943-43-3
  • C24H29N5O6