ChemicalBook > CAS DataBase List > 2,4-Diamino-6-hydroxypyrimidine

2,4-Diamino-6-hydroxypyrimidine

Product Name: 2,4-Diamino-6-hydroxypyrimidine
CAS No.: 56-06-4
Chemical Name: 2,4-Diamino-6-hydroxypyrimidine
Synonyms: 1956-6-4;2,6-DIAMINOPYRIMIDIN-4-OL;DAHP;2,6-Diaminopyrimidin-4(1H)-one;2,6-DIAMINO-4-PYRIMIDINOL;2,6-diamino-1H-pyrimidin-4-one;2,6-DIAMINO-4-HYDROXYPYRIMIDINE;4(3H)-pyrimidinone, 2,6-diamino-;9-60-9;NSC 9302
CBNumber: CB0174912
Molecular Formula: C4H6N4O
Formula Weight: 126.12
MOL File: 56-06-4.mol

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2,4-Diamino-6-hydroxypyrimidine Property

Melting point:: 285-286 °C (dec.) (lit.)
Boiling point:: 234.22°C (rough estimate)
Density: 1.3659 (rough estimate)
refractive index: 1.7990 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 10.61±0.50(Predicted)
form: Fine Crystalline Powder
color: White to cream
Sensitive: Light Sensitive
Merck: 14,2981
BRN: 125006
InChIKey: SWELIMKTDYHAOY-UHFFFAOYSA-N
CAS DataBase Reference: 56-06-4(CAS DataBase Reference)
NIST Chemistry Reference: 4(1H)-pyrimidinone, 2,6-diamino-(56-06-4)
EPA Substance Registry System: 2,6-Diamino-4(1H)-pyrimidinone (56-06-4)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-36-26
WGK Germany: 3
Hazard Note: Irritant
TSCA: Yes
HS Code: 29335995

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D1321
Product name: 2,4-Diamino-6-hydroxypyrimidine
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $76
Updated: 2025/07/31

Cayman Chemical

Product number: 81260
Product name: 2,4-Diamino-6-hydroxypyrimidine
Purity: ≥98%
Packaging: 1g
Price: $26
Updated: 2024/03/01

Cayman Chemical

Product number: 81260
Product name: 2,4-Diamino-6-hydroxypyrimidine
Purity: ≥98%
Packaging: 5g
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 81260
Product name: 2,4-Diamino-6-hydroxypyrimidine
Purity: ≥98%
Packaging: 10g
Price: $74
Updated: 2024/03/01

Cayman Chemical

Product number: 81260
Product name: 2,4-Diamino-6-hydroxypyrimidine
Purity: ≥98%
Packaging: 25g
Price: $93
Updated: 2024/03/01

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2,4-Diamino-6-hydroxypyrimidine Chemical Properties,Usage,Production

Description

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC₅₀ for inhibition of BH₄ biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.

Chemical Properties

White Solid

Uses

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.[Cayman Chemical]

Uses

2,4-Diamino-6-hydroxypyrimidine (cas# 56-06-4) is a compound useful in organic synthesis.

Uses

It stands at the beginning of the enzyme-catalyzed cascade that starts with this seven-carbon carbohydrate and ends with the aromatic amino acids phenylalanine, tyrosine, and tryptophan

Synthesis

A solution of sodium ethoxide is prepared from 23 g. (1 g. atom) of sodium and 250 ml of anhydrous ethanol in a 1-l round-bottomed flask fitted with a reflux condenser carrying a calcium chloride drying tube. After the sodium has dissolved, the solution is cooled and 113 g. (1 mole) of ethyl cyanoacetate is added. This mixture is allowed to stand while a second solution of sodium ethoxide of the same volume and concentration is prepared. To this solution is added 97 g. (1.02 moles) of guanidine hydrochloride. The sodium chloride is separated by filtration, and the clear filtrate containing guanidine is added to the solution of ethyl sodiocyanoacetate. This mixture is heated for 2 hours under reflux and is then evaporated to dryness at atmospheric pressure. The solid product is dissolved in 325 ml. of boiling water and acidified with 67 ml. of glacial acetic acid. Upon cooling of the solution, 101–103 g. (80–82%) of yellow needles separates; m.p. 260–270° (dec.)

storage

+4°C

Purification Methods

2,4-Diamino-6-hydroxypyrimidine recrystallises from H2O. [Beilstein 25 III/IV 3642.]

References

[1] Patent: CN107857734, 2018, A. Location in patent: Paragraph 0032; 0033; 0034; 0035

2,4-Diamino-6-hydroxypyrimidine Preparation Products And Raw materials

Raw materials

Guanidine nitrate Methyl cyanoacetate

Preparation Products

2,4-DIAMINO-6-MERCAPTOPYRIMIDINE 2,6-DIAMINO-4-METHOXY PYRIMIDINE

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View Lastest Price from 2,4-Diamino-6-hydroxypyrimidine manufacturers

Shandong Vital Biotechnology Co., Ltd.

Product: 2,4-Diamino-6-hydroxypyrimidine 56-06-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100tons
Release date: 2025-11-19

Shaanxi Dideu New Materials Co. Ltd

Product: 2,4-Diamino-6-hydroxypyrimidine 56-06-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-31

Anhui Ruihan Technology Co., Ltd

Product: 2,4-Diamino-6-hydroxypyrimidine 56-06-4
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000t/year
Release date: 2023-09-08

56-06-4, 2,4-Diamino-6-hydroxypyrimidineRelated Search:

Triclosan 1,3-Dihydroxyacetone 4,4'-Methylenedianiline Iminodiacetic acid 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL 4-Hydroxy-6-aminopyrimidine 1-Hydroxyethylidene-1,1-diphosphonic acid 1,3-Diaminoguanidine monohydrochloride Iminodiacetonitrile 4-[2’-(7’’-Deazaguanine)ethyl]benzoic Acid N-Hydroxysuccinimide Ester Methyl 4-(4-oxobutyl)benzoate N-[4-[3-(2,6-DiaMino-1,4-dihydro-4-oxo-5-pyriMidinyl)-3-oxopropyl]benzoyl]-L-glutaMic Acid 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid 3-Buten-1-ol PeMetrexed IMpurity D PeMetrexed EP IMpurity C Methyl 4-bromobenzoate Benzoic acid, 4-(1-methyl-3-oxopropyl)-, methyl ester (9CI)

TIMTEC-BB SBB004252

2,4-DIAMINOPYRIMIDIN-6-OL

2,4-DIAMINO-6-HYDROXYPYRIMIDINE

2,4-DIAMINO-6-PYRIMIDINOL

2,4-DIAMINO-6(1H)-PYRIMIDINONE

2,6-DIAMINO-4-PYRIMIDINOL

2,6-DIAMINO-4-PYRIMIDINONE

2,6-DIAMINOPYRIMIDIN-4-OL

2,6-DIAMINO-4(1H)-PYRIMIDINONE

2,6-DIAMINO-4-HYDROXYPYRIMIDINE

AURORA KA-376

DAHP

AKOS MSC-0109

2,6-Diamino-4-Hydroxyprimidine

2,6-diamino-1H-pyrimidin-4-one

2-4-DIAMINO6HYDROXY PYRIMID

2,4- two-6- aMinohydroxy pyriMidine

2,4-DiaMino-6-hydroxypyriMidine 96%

2,4-DiaMino-6-hydroxypyriMidine, 97+%

3-methylidene-1,5-benzodioxepine

Pemetrexed Impurity 16

4(3H)-pyrimidinone, 2,6-diamino-

InChI=1/C4H6N4O/c5-2-1-3(9)8-4(6)7-2/h1H,(H5,5,6,7,8,9

1956-6-4

2,4-Diamino-6-hydroxypyrimidiine

4(1H)-Pyrimidinone, 2,6-diamino- (8CI,9CI)

2,6-Diaminopyrimidin-4-one

6-Aminoisocytosine

NSC 44914

NSC 680818

NSC 9302

2,4-Diamino-6-hydroxy

2,4-diaminohypoxanthine

2,6-Diamino-1H-pyrimidin-4-on

2,4-Diamino-6. -Hydroxypyimidine

2,6-DIAMINO-3H-PYRIMIDIN-4-ONE

4(1H)-Pyrimidinone, 2,6-diamino

2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol, 2,6-Diamino-4-pyrimidinone

2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol

2,4-Diamino-6-pyrimidinone

2,6-Diamino-3,4-dihydropyrimidine-4-one

2,6-Diamino-4(3H)-pyrimidinone

2,6-Diaminopyrimidin-4(1H)-one

2,4-Diamino-6-hydroxypyrimidine,2,4-Diamino-6-hydroxypyrimidine, 2,6-Diamino-4-pyrimidinol, 2,6-Diamino-4-pyrimidinone

4-DiaMino-6-hydroxypyriMidine

2,4-Diamino-6-hydroxypyrimidine,96%

2,4-DIAMINO-6-HYDROXYPYRIDIMIDINE

6-Hydroxy-2,4-diaminopyrimidine

2,4-Diamino-6-hydroxypyrimidine &gt

2,4-Diamino-6-hydroxypyrimidine ISO 9001：2015 REACH

2,4-Diamino-6-hydroxypyrimidine,56-06-4

NSC 18522

NSC18522

NSC-18522

Minoxidil Impurity 19

2,4-Diamino-6-hydroxypyrimidine(98.60%)

9-60-9

2.4-Diamino-6-pyrimidone