Description
ChemicalBook > CAS DataBase List > Methyl cyanoacetate

Methyl cyanoacetate

Description
Product Name
Methyl cyanoacetate
CAS No.
105-34-0
Chemical Name
Methyl cyanoacetate
Synonyms
Methyl 2-cyanoacetate;2-cyanopropanoate;CYANOACETIC ACID METHYL ESTER;MCYA;usafkf-22;USAF kf-22;25KG,100KG,1T;Methylcyanacetat;METHYL CYANOACETATE;MetthylCyanoacetate
CBNumber
CB9485583
Molecular Formula
C4H5NO2
Formula Weight
99.09
MOL File
105-34-0.mol
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Methyl cyanoacetate Property

Melting point:
-13 °C
Boiling point:
204-207 °C(lit.)
Density 
1.123 g/mL at 25 °C(lit.)
vapor density 
3.41 (vs air)
vapor pressure 
0.2 mm Hg ( 20 °C)
refractive index 
n20/D 1.417(lit.)
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
54g/l
form 
Liquid
pka
2.75±0.10(Predicted)
color 
Clear colorless to very slightly yellow
Water Solubility 
54 g/L (20 ºC)
Sensitive 
Light Sensitive
BRN 
773945
Dielectric constant
29.4(21℃)
LogP
-0.47 at 25℃
CAS DataBase Reference
105-34-0(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, cyano-, methyl ester(105-34-0)
EPA Substance Registry System
Acetic acid, cyano-, methyl ester (105-34-0)
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Safety

Hazard Codes 
Xi
Safety Statements 
24/25
WGK Germany 
1
RTECS 
AG4375000
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29269095
Toxicity
guinea pig,LDLo,skin,400mg/kg (400mg/kg),"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 920, 1986.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
108421
Product name
Methyl cyanoacetate
Purity
99%
Packaging
25g
Price
$57.4
Updated
2024/03/01
Sigma-Aldrich
Product number
108421
Product name
Methyl cyanoacetate
Purity
99%
Packaging
2kg
Price
$209
Updated
2023/06/20
TCI Chemical
Product number
C0442
Product name
Methyl Cyanoacetate
Purity
>99.0%(GC)
Packaging
25mL
Price
$34
Updated
2024/03/01
TCI Chemical
Product number
C0442
Product name
Methyl Cyanoacetate
Purity
>99.0%(GC)
Packaging
500mL
Price
$75
Updated
2024/03/01
Alfa Aesar
Product number
A15555
Product name
Methyl cyanoacetate, 99%
Packaging
250g
Price
$43.2
Updated
2024/03/01
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Methyl cyanoacetate Chemical Properties,Usage,Production

Description

Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds. It is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate; a compound used in the synthesis of DPP-IV inhibitors for treating type-2 diabetes. In addition, it is an intermediate in the preparation of α-cyanoacrylate, malononitrile, and 1,1-cyclohexanediacetic acid dyes. It is used as UV absorber or stabilizer, intermediate for pharmaceuticals. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds.

Chemical Properties

clear colorless to very slighlty yellow liquid

Uses

pharmaceutical intermediate

Uses

Methyl cyanoacetate is an intermediate in the preparation of α-cyanoacrylate, malononitrile, 1,1-cyclohexanediacetic acid dye. It is used as UV absorber or stabiliser, intermediate for pharmaceuticals. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds.

Definition

ChEBI: Methyl cyanoacetate is an alkyl cyanoacetate ester.

General Description

Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Kn?venagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α-cyanocinnamic esters.

Purification Methods

Purify the ester by shaking with 10% Na2CO3 solution, wash well with water, dry with anhydrous Na2SO4, and distil it. [Beilstein 2 H 584, 2 I 253, 2 II 530, 2 III 1628, 2 IV 1889.]

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View Lastest Price from Methyl cyanoacetate manufacturers

Weijer International Trade (Hebei) Co., Ltd
Product
Methyl cyanoacetate 105-34-0
Price
US $1.00/KG
Min. Order
1KG
Purity
>99%
Supply Ability
3000T
Release date
2023-03-20
Anhui Rencheng Technology Co., Ltd
Product
Methyl cyanoacetate 105-34-0
Price
US $1.00-180.00/KG
Min. Order
0.5KG
Purity
>99%
Supply Ability
20tons
Release date
2021-01-04
Hebei Guanlang Biotechnology Co,.LTD
Product
Methyl Cyanoacetate 105-34-0
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2023-02-20

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