4-Amino-6-chloropyrimidine

Product Name: 4-Amino-6-chloropyrimidine
CAS No.: 5305-59-9
Chemical Name: 4-Amino-6-chloropyrimidine
Synonyms: H50551;NSC 42134;4-Amino-6-chL;4-Amino-6-chloropyri;6-Chloro-4-pyrimidinamine;6-Chloropyrimidin-4-amine;6-Chloropyrimidine-4-amine;6-AMino-4-chloropyriMidine;2-CHLORO-6-AMINOPYRIMIDINE;4-AMINO-6-CHLOROPYRIMIDINE
CBNumber: CB4424750
Molecular Formula: C4H4ClN3
Formula Weight: 129.55
MOL File: 5305-59-9.mol

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4-Amino-6-chloropyrimidine Property

Melting point:: 215-216°C
Boiling point:: 289.0±20.0 °C(Predicted)
Density: 1.437±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO
form: Solid
pka: 2.16±0.10(Predicted)
color: Pale Yellow
InChI: InChI=1S/C4H4ClN3/c5-3-1-4(6)8-2-7-3/h1-2H,(H2,6,7,8)
InChIKey: DUKKRSPKJMHASP-UHFFFAOYSA-N
SMILES: C1=NC(Cl)=CC(N)=N1
CAS DataBase Reference: 5305-59-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39-36/37
WGK Germany: 3
Hazard Note: Harmful
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 735272
Product name: 4-Amino-6-chloropyrimidine
Purity: 97%
Packaging: 1g
Price: $47.9
Updated: 2023/06/20

TCI Chemical

Product number: A2136
Product name: 4-Amino-6-chloropyrimidine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $43
Updated: 2025/07/31

TCI Chemical

Product number: A2136
Product name: 4-Amino-6-chloropyrimidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $126
Updated: 2025/07/31

Usbiological

Product number: A1376-61
Product name: 4-Amino-6-chloropyrimidine
Packaging: 2g
Price: $389
Updated: 2021/12/16

Chem-Impex

Product number: 44846
Product name: 4-Amino-6-chloropyrimidine,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 1G
Price: $36.7
Updated: 2021/12/16

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4-Amino-6-chloropyrimidine Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Anticancer Research

4-Amino-6-chloropyrimidine has been shown to inhibit the proliferation of cancer cells in vitro and in vivo, without affecting normal cells. 4-Amino-6-chloropyrimidine also inhibits kinase activity and protein synthesis in cancer cells. This drug has a potent inhibitory effect on cell proliferation.

Synthesis

1193-21-1

5305-59-9

The general procedure for the synthesis of 4-amino-6-chloropyrimidine from 4,6-dichloropyrimidine was as follows: to a suspension of 4,6-dichloropyrimidine (3.0 g, 20 mmol) in isopropanol (40 mL) was slowly added the appropriate amine, with the rate of addition being controlled so as to maintain the internal temperature of the reaction system at no more than 40°C. The reaction mixture was stirred continuously for 1 hour at 25°C. After addition, the reaction mixture was stirred continuously at 25 °C for 1 hour. Upon completion of the reaction, water (30 mL) was added and the resulting suspension was cooled to 0 °C in an ice bath. The precipitated product was collected by filtration and washed sequentially with pre-cooled isopropanol/water solvent mixture (V/V=2:1, 50 mL) and pure water. Finally, the resulting solid product was dried under vacuum to obtain the target compound 4-amino-6-chloropyrimidine.

References

[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 20, p. 7066 - 7083
[2] European Journal of Medicinal Chemistry, 2014, vol. 75, p. 11 - 20
[3] Patent: WO2012/35039, 2012, A1. Location in patent: Page/Page column 84
[4] Patent: US2012/15943, 2012, A1. Location in patent: Page/Page column 54
[5] ChemMedChem, 2017, vol. 12, # 16, p. 1390 - 1398

4-Amino-6-chloropyrimidine Preparation Products And Raw materials

Raw materials

Acetamide Methyl propionate Methyl cyanoacetate

Preparation Products

4-Amino-6-methoxypyrimidine

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4-Amino-6-chloropyrimidine Suppliers

Americas 1 Austria 1 Canada 2 China 311 Europe 3 Germany 3 India 16 Japan 2 Russia 1 Slovakia 1 United Kingdom 14 United States 47 Global 402

Shanghai Hekang Biotechnology Co., Ltd.

Tel: 18939837085
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J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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future industrial shanghai co., ltd

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TCI (Shanghai) Development Co., Ltd.

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ShangHai DEMO Chemical Co.,Ltd

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Energy Chemical

Tel: 021-021-58432009 400-005-6266
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Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
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View Lastest Price from 4-Amino-6-chloropyrimidine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Amino-6-chloropyrimidine 5305-59-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

Shaanxi Dideu Medichem Co. Ltd

Product: 4-AMino-6-chloropyriMidine 5305-59-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-Amino-6-chloropyrimidine 5305-59-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

5305-59-9, 4-Amino-6-chloropyrimidineRelated Search:

Acetaminophen Sulfamic acid Glycine ALTRENOGEST 3-Aminophenol 4-Aminopyrimidine Aminopyrine EC 2.6.1.2 6-Aminocaproic acid 2-Chloropyrimidine Glucosamine Tris(hydroxymethyl)aminomethane 2-Aminobenzylchloride 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE Difluorochloromethane 4-Chloro-2,6-diaminopyrimidine 6-CHLORO-5-NITROPYRIMIDIN-4-AMINE N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-4-METHYLBENZAMIDE

4-AMINO-6-CHLOROPYRIMIDINE

6-CHLORO-PYRIMIDIN-4-YLAMINE

4-Pyrimidinamine, 6-chloro- (9CI)

2-CHLORO-6-AMINOPYRIMIDINE

6-Chloro-4-pyrimidinamine

6-CHLORO-PYRIMIDIN-4-YLAMINE 98%

6-Chloropyrimidin-4-amine

NSC 42134

6-AMino-4-chloropyriMidine

6-Chloropyrimidine-4-amine

4-(4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)benzene-1-sulfonyl chloride

6-chloro-4-aminopyrimidine

4-Amino-6-chloropyri

6-Chloropyrimidin-4-amine, 4-Amino-6-chloro-1,3-diazine

4-Chloro-6-aminopyrimidine

4-AMino-6-chloropyriMidine, 98%, 98%

4-Amino-6-chloropyrimidine 97%

H50551

4-Amino-6-chloropyrimidine &gt

4-Amino-6-chL

4-Pyrimidinamine, 6-chloro-

5305-59-9

C4H4ClN3

AMINE

chloropyrimidin

Heterocycle-Pyrimidine series

amine| alkyl chloride

Biochemistry

Nucleobases and their analogs

Nucleosides, Nucleotides & Related Reagents

Bases & Related Reagents

Nucleotides

Nucleotides and Nucleosides

Pyrimidines

Amines and Anilines

Heterocycles

PYRIMIDINE

Heterocycles Nucleotides

Amines

bc0001