4-Amino-6-chloro-2-(methylthio)pyrimidine

Uses

Product Name: 4-Amino-6-chloro-2-(methylthio)pyrimidine
CAS No.: 1005-38-5
Chemical Name: 4-Amino-6-chloro-2-(methylthio)pyrimidine
Synonyms: U 8342;TIMTEC-BB SBB003786;1-[butoxy(phenyl)methyl]piperidine;6-Chloro-2-methylthio-4-pyrimidinamine;6-chloro-2-methylthiopyrimidin-4-ylamine;6-CHLORO-2-(METHYLTHIO)PYRIMIDIN-4-AMINE;4-AMINO-6-CHLORO-2-(METHYLTHIO)PYRIMIDINE;2-(Methylthio)-6-chloropyrimidine-4-amine;4-Pyrimidinamine, 6-chloro-2-(methylthio)-;6-AMINO-4-CHLORO-2-METHYLMERCAPTOPYRIMIDINE
CBNumber: CB6171009
Molecular Formula: C5H6ClN3S
Formula Weight: 175.64
MOL File: 1005-38-5.mol

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4-Amino-6-chloro-2-(methylthio)pyrimidine Property

Melting point:: 130-132 °C (lit.)
Boiling point:: 338.7±22.0 °C(Predicted)
Density: 1.395 (estimate)
refractive index: 1.6100 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: Crystalline Powder
pka: 1.11±0.10(Predicted)
color: Off-white to beige or yellow
InChI: 1S/C5H6ClN3S/c1-10-5-8-3(6)2-4(7)9-5/h2H,1H3,(H2,7,8,9)
InChIKey: ISUXMAHVLFRZQU-UHFFFAOYSA-N
SMILES: CSc1nc(N)cc(Cl)n1
CAS DataBase Reference: 1005-38-5(CAS DataBase Reference)
NIST Chemistry Reference: Pyrimidine, 4-amino-6-chloro-2-(methylthio)-(1005-38-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26
WGK Germany: 3
HS Code: 29335990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A46005
Product name: 4-Amino-6-chloro-2-(methylthio)pyrimidine
Purity: 97%
Packaging: 5g
Price: $93.4
Updated: 2023/01/07

Sigma-Aldrich

Product number: A46005
Product name: 4-Amino-6-chloro-2-(methylthio)pyrimidine
Purity: 97%
Packaging: 25g
Price: $444
Updated: 2023/01/07

TCI Chemical

Product number: A2848
Product name: 4-Amino-6-chloro-2-(methylthio)pyrimidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $62
Updated: 2025/07/31

TCI Chemical

Product number: A2848
Product name: 4-Amino-6-chloro-2-(methylthio)pyrimidine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $356
Updated: 2021/12/16

TRC

Product number: A617393
Product name: 4-Amino-6-chloro-2-(methylthio)pyrimidine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

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4-Amino-6-chloro-2-(methylthio)pyrimidine Chemical Properties,Usage,Production

Uses

4-Amino-6-chloro-2-(methylthio)pyrimidine is a halogenated heterocycle, a useful synthesis intermediate.

Chemical Properties

off-white to beige or yellow crystalline powder

Uses

4-Amino-6-chloro-2-(methylthio)pyrimidine is a halogenated heterocycle, a useful synthesis intermediate.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 1098, 1955 DOI: 10.1021/ja01610a006

Synthesis

6299-25-8

1005-38-5

General procedure for the synthesis of 4-amino-6-chloro-2-(methylthio)pyrimidine from 4,6-dichloro-2-(methylthio)pyrimidine: 1. 4,6-Dichloro-2-(methylthio)pyrimidine was added slowly in a 2L autoclave with THF and ammonia. 2. The reaction mixture was heated to 50-60°C and kept at that temperature for 3-4 hours (pressure in the reactor was maintained at 7-8 Kg/cm2). 3. The progress of the reaction was monitored by TLC. 4. After completion of the reaction, the reaction mixture was cooled to 25-35°C. 5. 5. Concentrate the reaction mixture under vacuum. 6. 6. Hexane was added and stirred at 25-35 °C for 30-45 min. 7. Collect the solid product by filtration and wash with hexane. 8. Wash the solid product with water (2 x 400 mL). 9. Dry the solid product at 25-35 °C until the moisture content (MC) is less than 2%. Yield: 352.0 g. Yield: 97.77%. HPLC purity: 99.07%. Note: For different analogs, other suitable conditions may be used, such as the use of methanol or dioxane solutions of ammonia. Example 1-2: Preparation of 4-amino-6-chloro-2-methylthiopyrimidine, step 6.1.

References

[1] Patent: WO2011/97594, 2011, A2. Location in patent: Page/Page column 100-101
[2] Chemistry - A European Journal, 1999, vol. 5, # 12, p. 3450 - 3458
[3] Patent: WO2007/141571, 2007, A2. Location in patent: Page/Page column 25
[4] American Chemical Journal, 1904, vol. 32, p. 353
[5] Patent: US2005/288502, 2005, A1. Location in patent: Page/Page column 20

4-Amino-6-chloro-2-(methylthio)pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Amino-6-chloro-2-(methylthio)pyrimidine Suppliers

Americas 1 Belgium 1 Canada 1 China 131 Europe 1 Germany 1 India 11 Japan 2 Switzerland 2 United Kingdom 9 United States 32 Global 192

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View Lastest Price from 4-Amino-6-chloro-2-(methylthio)pyrimidine manufacturers

Henan Fengda Chemical Co., Ltd

Product: 4-Amino-6-chloro-2-(methylthio)pyrimidine 1005-38-5
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Dideu Industries Group Limited

Product: 4-Amino-6-chloro-2-(methylthio)pyrimidine 1005-38-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-Amino-6-chloro-2-(methylthio)pyrimidine 1005-38-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

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4-Amino-6-chloro-2-(methylthio)pyrimidine ISO 9001：2015 REACH

1005-38-5

C5H6ClN3S

Heterocyclic Building Blocks

Halogenated Heterocycles

Pyrimidines

HETERO CHLORIDE

Building Blocks

C4 to C5

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyrimidines

PyrimidinesHeterocyclic Building Blocks

Heterocycle-Pyrimidine series

Sulphur Derivatives