4-Amino-6-chloro-2-(methylthio)pyrimidine
Uses- Product Name
- 4-Amino-6-chloro-2-(methylthio)pyrimidine
- CAS No.
- 1005-38-5
- Chemical Name
- 4-Amino-6-chloro-2-(methylthio)pyrimidine
- Synonyms
- U 8342;TIMTEC-BB SBB003786;1-[butoxy(phenyl)methyl]piperidine;6-Chloro-2-methylthio-4-pyrimidinamine;6-chloro-2-methylthiopyrimidin-4-ylamine;6-CHLORO-2-(METHYLTHIO)PYRIMIDIN-4-AMINE;4-AMINO-6-CHLORO-2-(METHYLTHIO)PYRIMIDINE;2-(Methylthio)-6-chloropyrimidine-4-amine;4-Pyrimidinamine, 6-chloro-2-(methylthio)-;6-AMINO-4-CHLORO-2-METHYLMERCAPTOPYRIMIDINE
- CBNumber
- CB6171009
- Molecular Formula
- C5H6ClN3S
- Formula Weight
- 175.64
- MOL File
- 1005-38-5.mol
4-Amino-6-chloro-2-(methylthio)pyrimidine Property
- Melting point:
- 130-132 °C (lit.)
- Boiling point:
- 338.7±22.0 °C(Predicted)
- Density
- 1.395 (estimate)
- refractive index
- 1.6100 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- Crystalline Powder
- pka
- 1.11±0.10(Predicted)
- color
- Off-white to beige or yellow
- InChIKey
- ISUXMAHVLFRZQU-UHFFFAOYSA-N
- CAS DataBase Reference
- 1005-38-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Pyrimidine, 4-amino-6-chloro-2-(methylthio)-(1005-38-5)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A46005
- Product name
- 4-Amino-6-chloro-2-(methylthio)pyrimidine
- Purity
- 97%
- Packaging
- 5g
- Price
- $93.4
- Updated
- 2023/01/07
- Product number
- A46005
- Product name
- 4-Amino-6-chloro-2-(methylthio)pyrimidine
- Purity
- 97%
- Packaging
- 25g
- Price
- $444
- Updated
- 2023/01/07
- Product number
- A2848
- Product name
- 4-Amino-6-chloro-2-(methylthio)pyrimidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $62
- Updated
- 2025/07/31
- Product number
- A2848
- Product name
- 4-Amino-6-chloro-2-(methylthio)pyrimidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $356
- Updated
- 2021/12/16
- Product number
- A617393
- Product name
- 4-Amino-6-chloro-2-(methylthio)pyrimidine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
4-Amino-6-chloro-2-(methylthio)pyrimidine Chemical Properties,Usage,Production
Uses
4-Amino-6-chloro-2-(methylthio)pyrimidine is a halogenated heterocycle, a useful synthesis intermediate.
Chemical Properties
off-white to beige or yellow crystalline powder
Uses
4-Amino-6-chloro-2-(methylthio)pyrimidine is a halogenated heterocycle, a useful synthesis intermediate.
Synthesis Reference(s)
Journal of the American Chemical Society, 77, p. 1098, 1955 DOI: 10.1021/ja01610a006
Synthesis
6299-25-8
1005-38-5
General procedure for the synthesis of 4-amino-6-chloro-2-(methylthio)pyrimidine from 4,6-dichloro-2-(methylthio)pyrimidine: 1. 4,6-Dichloro-2-(methylthio)pyrimidine was added slowly in a 2L autoclave with THF and ammonia. 2. The reaction mixture was heated to 50-60°C and kept at that temperature for 3-4 hours (pressure in the reactor was maintained at 7-8 Kg/cm2). 3. The progress of the reaction was monitored by TLC. 4. After completion of the reaction, the reaction mixture was cooled to 25-35°C. 5. 5. Concentrate the reaction mixture under vacuum. 6. 6. Hexane was added and stirred at 25-35 °C for 30-45 min. 7. Collect the solid product by filtration and wash with hexane. 8. Wash the solid product with water (2 x 400 mL). 9. Dry the solid product at 25-35 °C until the moisture content (MC) is less than 2%. Yield: 352.0 g. Yield: 97.77%. HPLC purity: 99.07%. Note: For different analogs, other suitable conditions may be used, such as the use of methanol or dioxane solutions of ammonia. Example 1-2: Preparation of 4-amino-6-chloro-2-methylthiopyrimidine, step 6.1.
References
[1] Patent: WO2011/97594, 2011, A2. Location in patent: Page/Page column 100-101
[2] Chemistry - A European Journal, 1999, vol. 5, # 12, p. 3450 - 3458
[3] Patent: WO2007/141571, 2007, A2. Location in patent: Page/Page column 25
[4] American Chemical Journal, 1904, vol. 32, p. 353
[5] Patent: US2005/288502, 2005, A1. Location in patent: Page/Page column 20
4-Amino-6-chloro-2-(methylthio)pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
4-Amino-6-chloro-2-(methylthio)pyrimidine Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 4-Amino-6-chloro-2-(methylthio)pyrimidine manufacturers
- Product
- 4-Amino-6-chloro-2-(methylthio)pyrimidine 1005-38-5
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 4-Amino-6-chloro-2-(methylthio)pyrimidine 1005-38-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-14
- Product
- 4-Amino-6-chloro-2-(methylthio)pyrimidine 1005-38-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10