ChemicalBook > CAS DataBase List > WY-14643

WY-14643

Product Name
WY-14643
CAS No.
50892-23-4
Chemical Name
WY-14643
Synonyms
CS-737;WY-14643;Pirinixic;NSC 310038;wyeth14,643;Chloro Acid;pirnixicacid;99.0%(LC&PIRINIXIC ACID;WY-14643/WY14643
CBNumber
CB9345027
Molecular Formula
C14H14ClN3O2S
Formula Weight
323.8
MOL File
50892-23-4.mol
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WY-14643 Property

Melting point:
155°C
Boiling point:
514.4±50.0 °C(Predicted)
Density 
1.2984 (rough estimate)
refractive index 
1.5630 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in DMSO (up to 40 mg/ml).
form 
White crystalline solid
pka
2.99±0.10(Predicted)
color 
Off-white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.
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Safety

Hazard Codes 
T
Risk Statements 
45-22-36/37/38
Safety Statements 
53-26-36/37/39-45
WGK Germany 
3
RTECS 
AG2915000
HS Code 
2933.59.9500
Hazardous Substances Data
50892-23-4(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C7081
Product name
WY-14643
Packaging
10mg
Price
$60.3
Updated
2024/03/01
Sigma-Aldrich
Product number
C7081
Product name
WY-14643
Packaging
50mg
Price
$194
Updated
2024/03/01
TCI Chemical
Product number
C1323
Product name
[4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid
Purity
>99.0%(HPLC)(T)
Packaging
1g
Price
$151
Updated
2024/03/01
TCI Chemical
Product number
C1323
Product name
[4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid
Purity
>99.0%(HPLC)(T)
Packaging
5g
Price
$454
Updated
2024/03/01
Cayman Chemical
Product number
70730
Product name
Wy 14643
Purity
≥98%
Packaging
5mg
Price
$16
Updated
2024/03/01
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WY-14643 Chemical Properties,Usage,Production

Description

WY-14643 (50892-23-4) is a selective PPARα agonist (EC50=0.63, 32 and >100 μM for PPARα,γ and δ, respectively).1? Displays anti-inflammatory activity2 and reduces LPS-induced inflammation in alveolar epithelial cells3. Induces “browning” of white adipocytes in combined treatment with retinoic acid.4? Stimulates ADAM10-mediated proteolysis of? amyloid precursor protein in a mouse model.5 Down regulates NFkB transcriptional activity. Review.6

Uses

A highly potent PPARα agonist

Uses

WY-14643 has been used:

  • as a positive control for transfection and luciferase assay
  • to stimulate bone marrow–derived macrophages (BMDM) for autophagic flux analysis
  • to analyze the regulation of fatty acid metabolism-immune nexus (FAMIN) expression in cell culture

Definition

ChEBI: Pirinixic acid is a member of pyrimidines, an organochlorine compound and an aryl sulfide. It is functionally related to an acetic acid.

General Description

WY-14643 prevents lipopolysaccharide (LPS)-induced inflammation in synovial fibroblasts. It protects cortical neurons from pro-inflammatory mediator-induced cell injuries. WY-14643 has inhibitory effects on pro-inflammatory responses in microglia. It improves oxido-nitrosative stress in disease models and reduces the generation of reactive oxygen species (ROS), nitric oxide (NO) and lipid peroxidation end-products in the brain.

Biological Activity

Selective PPAR α agonist (EC 50 values are 0.63, 32 and > 100 μ M at PPAR α , PPAR γ and PPAR δ respectively). Negatively inhibits NF- κ B transcriptional activity and decreases the inflammatory response in vitro and in vivo .

Biochem/physiol Actions

Selective PPARα agonist.

Safety Profile

Moderately toxic by ingestion. Suspected carcinogen with experimental carcinogenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl-, NOx and SOx

storage

Store at RT

References

1) Forman et al. (1997), Hypolipidemic drugs, polyunsaturated fatty acids and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta; Proc. Natl. Acad. Sci. USA, 94 4312 2) Devchand et al. (1996), The PPARalpha-leukotriene B4 pathway to inflammation control; Nature, 384 39 3) Heckler et al. (2015), PPAR-a activation reduced LPS-induced inflammation in alveolar epithelial cells; Exp. Lung Res., 41 393 4) Wang et al. (2015), WY14643 combined with all-trans retinoic acid acts via p38 MAPK to induce “browning” of white adipocytes in mice; Genet. Mol. Res., 14 6978 5) Corbett et al. (2015), Activation of peroxisome proliferator-activated receptor alpha stimulates ADAM10-mediated proteolysis of APP; Proc. Natl. Acad. Sci. USA, 112 8445 6) Merk et al. (2015), Pirinixic acids: flexible fatty acid mimetics with various biological activities; Future Med. Chem., 7 1597

WY-14643 Preparation Products And Raw materials

Raw materials

Preparation Products

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WY-14643 Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9809
Advantage
59
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
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View Lastest Price from WY-14643 manufacturers

Career Henan Chemical Co
Product
WY-14643 50892-23-4
Price
US $8.00/KG
Min. Order
1KG
Purity
>98% HPLC
Supply Ability
20 tons
Release date
2020-02-17

50892-23-4, WY-14643Related Search:


  • WY-14643/WY14643
  • ((4-chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio)-aceticaci
  • ((4-chloro-6-(2,3-xylidino)-2-pyrimidinyl)thio)-aceticaci
  • 4-chloro-6-(2,3-xylidino)-2-*pyrimidinylthioaceti
  • pirnixicacid
  • NSC 310038
  • Acetic acid, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-
  • wyeth14,643
  • [4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO]-2-PYRIMIDINYL]THIACETIC ACID
  • (4-CHLORO-6-[(2,3-DIMETHYLPHENYL)AMINO]-2-PYRIMIDINYL)THIOACETIC ACID
  • [4-CHLORO-6-(2,3-XYLIDINO)-2-PYRIMIDINYLTHIO]ACETIC ACID
  • PIRINIXIC ACID
  • WY-14643
  • Pirinixic
  • (4-CHLORO-6-(2,3-XYLIDINO)-2-PYRIMIDYL-THIO)ACETICACID
  • 4-CHLORO-6-(2,3-XYLIDINO)-2- PYRIMIDINYLTHIOACETIC
  • 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid, Pirinixic acid
  • [[4-Chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl]thio]acetic acid
  • pirinixic acid (WY 14643)
  • WY-14643 (Pirinixic Acid)
  • WY-14643 - CAS 50892-23-4 - Calbiochem
  • WY14643; PIRINIXIC ACID;WY 14643;WY-14643
  • CS-737
  • [4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid &gt
  • Chloro Acid
  • 99.0%(LC&amp
  • WY-14643 USP/EP/BP
  • 2-((4-Chloro-6-((2,3-dimethylphenyl)amino)pyrimidin-2-yl)thio)acetic acid
  • WY 14643, PPARalpha agonist
  • 50892-23-4
  • Gene Regulation and Expression
  • PPAR and RXR Regulators
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Inhibitors
  • Intracellular receptor
  • Inhibitor