4-Chloro-2-methylthiopyrimidine

Product Name: 4-Chloro-2-methylthiopyrimidine
CAS No.: 49844-90-8
Chemical Name: 4-Chloro-2-methylthiopyrimidine
Synonyms: 4-CHLORO-2-(METHYLTHIO)PYRIMIDINE;4-CHLORO-2-METHYLSULFANYL-PYRIMIDINE;4-Chloro-2-(Methylthio)py...;2-methylthio-4-chloropyrimine;6-Chloro-2-methylthiopyrimidine;2-(Methylthio)-4-chloropyrimidine;4-Chloro-2-methylthiopyrimidine,97%;PYRIMIDINE, 4-CHLORO-2-(METHYLTHIO)-;4-Chloro-2-(methylthio)pyrimidine 97%;4-Chloro-2-(methylmercapto)pyrimidine
CBNumber: CB9149799
Molecular Formula: C5H5ClN2S
Formula Weight: 160.62
MOL File: 49844-90-8.mol

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4-Chloro-2-methylthiopyrimidine Property

Melting point:: −2 °C(lit.)
Boiling point:: 139-140 °C36 mm Hg(lit.)
Density: 1.381 g/mL at 25 °C(lit.)
refractive index: n20/D 1.6(lit.)
Flash point:: >230 °F
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: liquid
pka: -0.56±0.20(Predicted)
color: Colorless to Red to Green
Water Solubility: Not miscible or difficult to mix in water.
Sensitive: Hygroscopic
BRN: 118042
InChI: InChI=1S/C5H5ClN2S/c1-9-5-7-3-2-4(6)8-5/h2-3H,1H3
InChIKey: DFOHHQRGDOQMKG-UHFFFAOYSA-N
SMILES: C1(SC)=NC=CC(Cl)=N1
CAS DataBase Reference: 49844-90-8(CAS DataBase Reference)

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-36/37/39-45
RIDADR: UN 1760 8/PG 2
WGK Germany: 3
F: 10-13-23
Hazard Note: Corrosive/Hygroscopic
HazardClass: 8
PackingGroup: III
HS Code: 29335990
Storage Class: 8A - Combustible corrosive hazardous materials
Hazard Classifications: Skin Corr. 1B

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 145289
Product name: 4-Chloro-2-methylthiopyrimidine
Purity: 98%
Packaging: 10g
Price: $52.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 145289
Product name: 4-Chloro-2-methylthiopyrimidine
Purity: 98%
Packaging: 50g
Price: $198.45
Updated: 2025/07/31

TCI Chemical

Product number: C3087
Product name: 4-Chloro-2-(methylthio)pyrimidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $56
Updated: 2025/07/31

TCI Chemical

Product number: C3087
Product name: 4-Chloro-2-(methylthio)pyrimidine
Purity: >98.0%(GC)
Packaging: 25g
Price: $167
Updated: 2025/07/31

TRC

Product number: C993410
Product name: 4-Chloro-2-(methylthio)pyrimidine
Packaging: 1g
Price: $45
Updated: 2021/12/16

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4-Chloro-2-methylthiopyrimidine Chemical Properties,Usage,Production

Chemical Properties

Clear yellow to brown liquid

Uses

It finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors.

Uses

4-Chloro-2-methylthiopyrimidine was used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It was used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors. It was used as building block in medicinal chemistry synthesis.

Synthesis

4-Chloro-2-methylthiopyrimidine can be produced from 2-thiouracil as raw material, dimethyl sulfate as methylation reagent, and thionyl chloride and phosphorus oxychloride as chlorination reagents by methylation and chlorination reaction.

4-Chloro-2-methylthiopyrimidine Preparation Products And Raw materials

Raw materials

Phosphorus oxitrichloride 2-Thiouracil 2-Methylthio-4-pyrimidinol Iodomethane

Preparation Products

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4-Chloro-2-methylthiopyrimidine Suppliers

Americas 1 Belgium 1 CHINA 232 Europe 1 Germany 5 India 11 Japan 1 Switzerland 1 United Kingdom 10 United States 31 Global 294

Changzhou Qinuo Chemical Co., Ltd.Co., Ltd.

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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View Lastest Price from 4-Chloro-2-methylthiopyrimidine manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 4-Chloro-2-methylthiopyrimidine 49844-90-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-28

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 4-Chloro-2-methylthiopyrimidine 49844-90-8
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-11-12

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Chloro-2-methylthiopyrimidine 49844-90-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-15

49844-90-8, 4-Chloro-2-methylthiopyrimidineRelated Search:

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PYRIMIDINE, 4-CHLORO-2-(METHYLTHIO)-

4-CHLORO-2-(METHYLTHIO)PYRIMIDINE

4-Chloro-2-(methylsulphanyl)pyrimidine

49844-90-8

C5H5ClN2S

Building Blocks

Heterocyclic Building Blocks

Halogenated Heterocycles

Pyrimidines

Pyrazines, Pyrimidines & Pyridazines

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyrimidines

PyrimidinesHeterocyclic Building Blocks

Pyrimidine

Halides

Pyrazines, Pyrimidines & Pyridazines

Heterocycle-Pyrimidine series