ChemicalBook > CAS DataBase List > 4-Chloro-2-methylthiopyrimidine

4-Chloro-2-methylthiopyrimidine

Product Name
4-Chloro-2-methylthiopyrimidine
CAS No.
49844-90-8
Chemical Name
4-Chloro-2-methylthiopyrimidine
Synonyms
4-CHLORO-2-(METHYLTHIO)PYRIMIDINE;4-CHLORO-2-METHYLSULFANYL-PYRIMIDINE;4-Chloro-2-(Methylthio)py...;2-methylthio-4-chloropyrimine;6-Chloro-2-methylthiopyrimidine;2-(Methylthio)-4-chloropyrimidine;4-Chloro-2-methylthiopyrimidine,97%;PYRIMIDINE, 4-CHLORO-2-(METHYLTHIO)-;4-Chloro-2-(methylthio)pyrimidine 97%;4-Chloro-2-(methylmercapto)pyrimidine
CBNumber
CB9149799
Molecular Formula
C5H5ClN2S
Formula Weight
160.62
MOL File
49844-90-8.mol
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4-Chloro-2-methylthiopyrimidine Property

Melting point:
−2 °C(lit.)
Boiling point:
139-140 °C36 mm Hg(lit.)
Density 
1.381 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.6(lit.)
Flash point:
>230 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
liquid
pka
-0.56±0.20(Predicted)
color 
Colorless to Red to Green
Water Solubility 
Not miscible or difficult to mix in water.
Sensitive 
Hygroscopic
BRN 
118042
InChI
InChI=1S/C5H5ClN2S/c1-9-5-7-3-2-4(6)8-5/h2-3H,1H3
InChIKey
DFOHHQRGDOQMKG-UHFFFAOYSA-N
SMILES
C1(SC)=NC=CC(Cl)=N1
CAS DataBase Reference
49844-90-8(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 1760 8/PG 2
WGK Germany 
3
F 
10-13-23
Hazard Note 
Corrosive/Hygroscopic
HazardClass 
8
PackingGroup 
III
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
145289
Product name
4-Chloro-2-methylthiopyrimidine
Purity
98%
Packaging
10g
Price
$52.6
Updated
2025/07/31
Sigma-Aldrich
Product number
145289
Product name
4-Chloro-2-methylthiopyrimidine
Purity
98%
Packaging
50g
Price
$198.45
Updated
2025/07/31
TCI Chemical
Product number
C3087
Product name
4-Chloro-2-(methylthio)pyrimidine
Purity
>98.0%(GC)
Packaging
5g
Price
$56
Updated
2025/07/31
TCI Chemical
Product number
C3087
Product name
4-Chloro-2-(methylthio)pyrimidine
Purity
>98.0%(GC)
Packaging
25g
Price
$167
Updated
2025/07/31
TRC
Product number
C993410
Product name
4-Chloro-2-(methylthio)pyrimidine
Packaging
1g
Price
$45
Updated
2021/12/16
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4-Chloro-2-methylthiopyrimidine Chemical Properties,Usage,Production

Chemical Properties

Clear yellow to brown liquid

Uses

It finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors.

Uses

4-Chloro-2-methylthiopyrimidine was used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It was used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors. It was used as building block in medicinal chemistry synthesis.

4-Chloro-2-methylthiopyrimidine Preparation Products And Raw materials

Raw materials

Phosphorus oxitrichloride 2-Thiouracil 2-Methylthio-4-pyrimidinol Iodomethane

Preparation Products

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4-Chloro-2-methylthiopyrimidine Suppliers

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View Lastest Price from 4-Chloro-2-methylthiopyrimidine manufacturers

Jinan Ruitong Biotech Co., Ltd.
Product
4-Chloro-2-methylthiopyrimidine 49844-90-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1
Release date
2025-08-28
Hebei Zhuanglai Chemical Trading Co Ltd
Product
4-Chloro-2-methylthiopyrimidine 49844-90-8
Price
US $50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-11-12
Shaanxi Dideu New Materials Co. Ltd
Product
4-Chloro-2-methylthiopyrimidine 49844-90-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-15

49844-90-8, 4-Chloro-2-methylthiopyrimidineRelated Search:

Phenyl chlorothionocarbonate ISOMETHIOZIN Pyrimidine Sulfamerazine tert-Butyldimethylsilyl chloride Meclofenoxate hydrochloride 2-(Dimethylamino)ethyl (4-chlorphenoxy)acetate 2-Chloro-5-chloromethylpyridine Chloromethyltrimethylsilane Chlorantraniliprole MCPA SODIUM Pirimiphos-methyl Thioridazine 4-Chloropyrimidine Difluorochloromethane 4,6-DICHLORO-2-METHYLTHIO-5-PHENYLPYRIMIDINE 5-Bromo-4-chloro-2-(methylthio)pyrimidine ,97%,5-Bromo-4-chloro-2-(methylthio)pyrimidine Chloromethyl methyl ether

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  • 2-methylthio-4-chloropyrimine
  • 2-(Methylthio)-4-chloropyrimidine
  • 4-Chloro-2-(methylthio)pyrimidine ,98%
  • 4-Chloro-2-(Methylthio)py...
  • 4-Chloro-2-(methylmercapto)pyrimidine, 4-Chloro-2-(methylsulphanyl)pyrimidine
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  • 4-Chloro-2-methylthiopyrimidine≥ 99% (GC)
  • PYRIMIDINE, 4-CHLORO-2-(METHYLTHIO)-
  • 4-CHLORO-2-(METHYLTHIO)PYRIMIDINE
  • 4-Chloro-2-(methylsulphanyl)pyrimidine
  • 49844-90-8
  • C5H5ClN2S
  • Building Blocks
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Pyrimidines
  • Pyrazines, Pyrimidines & Pyridazines
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyrimidines
  • PyrimidinesHeterocyclic Building Blocks
  • Pyrimidine
  • Halides
  • Pyrazines, Pyrimidines & Pyridazines
  • Heterocycle-Pyrimidine series