Wnt-C59
- Product Name
- Wnt-C59
- CAS No.
- 1243243-89-1
- Chemical Name
- Wnt-C59
- Synonyms
- C59;CS-876;Wnt-C59;Wnt-C59 (C59);Wnt-C59, >=98%;Wnt-C59 USP/EP/BP;WNT C59; C59;WNTC59;WNT-C59 (C59);WNT C59;C59;Porcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem;Wnt-C59, 98%, a potent PORCN enzymatic activity and Wnt inhibitor
- CBNumber
- CB62645245
- Molecular Formula
- C25H21N3O
- Formula Weight
- 379.45
- MOL File
- 1243243-89-1.mol
Wnt-C59 Property
- Melting point:
- >159°C (dec.)
- Boiling point:
- 628.3±55.0 °C(Predicted)
- Density
- 1.198±0.06 g/cm3(Predicted)
- storage temp.
- +2C to +8C
- solubility
- Soluble in DMSO (up to 7 mg/ml) or in Ethanol (up to 6 mg/mL)
- form
- Off-white powder
- pka
- 13.78±0.70(Predicted)
- color
- Tan
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5.00496
- Product name
- Porcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem
- Packaging
- 10MG
- Price
- $191
- Updated
- 2024/03/01
- Product number
- 16644
- Product name
- Wnt-C59
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 16644
- Product name
- Wnt-C59
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 16644
- Product name
- Wnt-C59
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 16644
- Product name
- Wnt-C59
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $723
- Updated
- 2024/03/01
Wnt-C59 Chemical Properties,Usage,Production
Description
Wnt-C59 (1243243-89-1) is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase.1 Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms.? It was able to block progression of mammary tumors in MMTV-WNT1 transgenic mice.1? Wnt-C59 strongly inhibited the growth of intestinal neoplasia in RZ-mutant mice.2? Wnt-C59 was able to efficiently differentiate pluripotent stem cells into cortical neurons (CTIP2+/COUP-TF1).3? Wnt-C59 was also able to dramatically attenuate kidney fibrosis via inhibition of collagen mRNA expression and expression of inflammatory cytokines.4
Uses
Wnt-C59 is a porcupine homolog – Drosophila (PORCN) inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase.
storage
-20°C
References
1) Proffitt et al. (2013), Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of Wnt-Driven Mammary Cancer; Cancer Res., 73 502 2) Koo et al. (2015), Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia; Proc. Natl. Acad. Sci.USA, 112 7548 3) Motono et al. (2016), Wnt-C59, a Small-Molecule Wnt Inhibitor, Efficiently Induces Anterior Cortex That Includes Cortical Motor Neurons From Human Pluripotent Stem Cells; Stem Cells Transl.Med., 5 552 4) Madan et al. (2016), Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis; Kidney Int., 89 1062
Wnt-C59 Preparation Products And Raw materials
Raw materials
Preparation Products
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