Wnt-C59
- Product Name
- Wnt-C59
- CAS No.
- 1243243-89-1
- Chemical Name
- Wnt-C59
- Synonyms
- C59;CS-876;Wnt-C59;Wnt-C59 (C59);Wnt-C59, >=98%;Wnt-C59 USP/EP/BP;Wnt-C59 (C59),≥98%;WNT C59; C59;WNTC59;Wnt-C59 (C59) ，S7037;Wnt-C59, 10 mM in DMSO
- CBNumber
- CB62645245
- Molecular Formula
- C25H21N3O
- Formula Weight
- 379.45
- MOL File
- 1243243-89-1.mol
Wnt-C59 Property
- Melting point:
- >159°C (dec.)
- Boiling point:
- 628.3±55.0 °C(Predicted)
- Density
- 1.198±0.06 g/cm3(Predicted)
- storage temp.
- +2C to +8C
- solubility
- Soluble in DMSO (up to 7 mg/ml) or in Ethanol (up to 6 mg/mL)
- form
- Off-white powder
- pka
- 13.78±0.70(Predicted)
- color
- Tan
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
- InChI
- InChI=1S/C25H21N3O/c1-18-15-22(12-14-27-18)20-6-4-19(5-7-20)16-25(29)28-24-10-8-21(9-11-24)23-3-2-13-26-17-23/h2-15,17H,16H2,1H3,(H,28,29)
- InChIKey
- KHZOJCQBHJUJFY-UHFFFAOYSA-N
- SMILES
- C1(CC(NC2=CC=C(C3=CC=CN=C3)C=C2)=O)=CC=C(C2C=CN=C(C)C=2)C=C1
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5.00496
- Product name
- Porcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem
- Packaging
- 10MG
- Price
- $196
- Updated
- 2025/07/31
- Product number
- 16644
- Product name
- Wnt-C59
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 16644
- Product name
- Wnt-C59
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 16644
- Product name
- Wnt-C59
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 16644
- Product name
- Wnt-C59
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $723
- Updated
- 2024/03/01
Wnt-C59 Chemical Properties,Usage,Production
Description
Wnt-C59 (1243243-89-1) is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase.1 Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms.? It was able to block progression of mammary tumors in MMTV-WNT1 transgenic mice.1? Wnt-C59 strongly inhibited the growth of intestinal neoplasia in RZ-mutant mice.2? Wnt-C59 was able to efficiently differentiate pluripotent stem cells into cortical neurons (CTIP2+/COUP-TF1).3? Wnt-C59 was also able to dramatically attenuate kidney fibrosis via inhibition of collagen mRNA expression and expression of inflammatory cytokines.4
Uses
Wnt-C59 is a porcupine homolog – Drosophila (PORCN) inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase.
in vivo
Wnt-C59 displays good bioavailability in mice. Wnt-C59 blocks progression of mammary tumors in MMTV-WNT1 transgenic mice while downregulating Wnt/β-catenin target genes[1]. Wnt-C59 has the potential to eradicate cancer stem cells in human tumors. Wnt-C59 inhibits stemness properties of NPC cells in a dosage-dependent manner by arresting sphere formation in both HNE1 and SUNE1 cells[2].
storage
-20°C
References
[1] KYLE DAVID PROFFITT. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer.[J]. Cancer research, 2013, 73 2: 502-507. DOI:10.1158/0008-5472.can-12-2258
[2] BON-KYOUNG KOO. Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 24: 7548-7550. DOI:10.1073/pnas.1508113112
[3] M. MOTONO. WNT‐C59, a Small‐Molecule WNT Inhibitor, Efficiently Induces Anterior Cortex That Includes Cortical Motor Neurons From Human Pluripotent Stem Cells[J]. Stem Cells Translational Medicine, 2016, 5 1. DOI:10.5966/sctm.2015-0261
[4] BABITA MADAN . Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis[J]. Kidney international, 2016, 89 5: Pages 1062-1074. DOI:10.1016/j.kint.2016.01.017
Wnt-C59 Preparation Products And Raw materials
Raw materials
Preparation Products
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