Wnt-C59

Product Name: Wnt-C59
CAS No.: 1243243-89-1
Chemical Name: Wnt-C59
Synonyms: C59;CS-876;Wnt-C59;Wnt-C59 (C59);Wnt-C59, >=98%;Wnt-C59 USP/EP/BP;WNT C59; C59;WNTC59;WNT-C59 (C59);WNT C59;C59;Porcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem;Wnt-C59, 98%, a potent PORCN enzymatic activity and Wnt inhibitor
CBNumber: CB62645245
Molecular Formula: C25H21N3O
Formula Weight: 379.45
MOL File: 1243243-89-1.mol

More

Less

Wnt-C59 Property

Melting point:: >159°C (dec.)
Boiling point:: 628.3±55.0 °C(Predicted)
Density: 1.198±0.06 g/cm3(Predicted)
storage temp.: +2C to +8C
solubility: Soluble in DMSO (up to 7 mg/ml) or in Ethanol (up to 6 mg/mL)
form: Off-white powder
pka: 13.78±0.70(Predicted)
color: Tan
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

More

Less

Safety

HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.00496
Product name: Porcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem
Packaging: 10MG
Price: $191
Updated: 2024/03/01

Cayman Chemical

Product number: 16644
Product name: Wnt-C59
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 16644
Product name: Wnt-C59
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 16644
Product name: Wnt-C59
Purity: ≥98%
Packaging: 10mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 16644
Product name: Wnt-C59
Purity: ≥98%
Packaging: 50mg
Price: $723
Updated: 2024/03/01

More

Less

Wnt-C59 Chemical Properties,Usage,Production

Description

Wnt-C59 (1243243-89-1) is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase.1 Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms.? It was able to block progression of mammary tumors in MMTV-WNT1 transgenic mice.1? Wnt-C59 strongly inhibited the growth of intestinal neoplasia in RZ-mutant mice.2? Wnt-C59 was able to efficiently differentiate pluripotent stem cells into cortical neurons (CTIP2+/COUP-TF1).3? Wnt-C59 was also able to dramatically attenuate kidney fibrosis via inhibition of collagen mRNA expression and expression of inflammatory cytokines.4

Uses

Wnt-C59 is a porcupine homolog – Drosophila (PORCN) inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase.

storage

-20°C

References

1) Proffitt et al. (2013), Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of Wnt-Driven Mammary Cancer; Cancer Res., 73 502 2) Koo et al. (2015), Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia; Proc. Natl. Acad. Sci.USA, 112 7548 3) Motono et al. (2016), Wnt-C59, a Small-Molecule Wnt Inhibitor, Efficiently Induces Anterior Cortex That Includes Cortical Motor Neurons From Human Pluripotent Stem Cells; Stem Cells Transl.Med., 5 552 4) Madan et al. (2016), Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis; Kidney Int., 89 1062

Wnt-C59 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Wnt-C59 Suppliers

China 121 India 2 United Kingdom 1 United States 19 Global 143

Wuxi Donghe Pharmaceutical Technology Co., Ltd.

Tel: 63313187 15358055255
Fax: QQ：63313187
Email: 63313187@qq.com
Country: China
ProdList: 1993
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: +86 (21) 5895-8628
Email: SALES@UHNSHANGHAI.COM
Country: China
ProdList: 977
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

EnliPharma Technology Co., Ltd

Tel: 0551-66399836 18955197623
Email: sales@enlipharma.com
Country: China
ProdList: 1874
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

1243243-89-1, Wnt-C59Related Search:

2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine WY-14643 WWL229 Wnt Agonist WS3 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenylbutane-1,4-dione Thiazovivin Y27632 (hydrochloride) xav-939 Sunitinib Malate CHIR-99021 PLX4032 WNT2 / IRP Antibody LS-C393214 WNT-3a, Human Recombinant Wnt5a Antibody Wnt-2b (C-2) Alexa Fluor? 488 Wnt-16 (B-4) Wnt-3a (3A6)

Wnt-C59

2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetaMide

C59

Wnt-C59 (C59)

4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide

4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide Wnt-c59

Wnt-C59, >=98%

WNT-C59 (C59);WNT C59;C59

2-[4-(2-Methyl-4-pyridyl)phenyl]-N-[4-(3-pyridyl)phenyl]acetamide

Wnt-C59, 98%, a potent PORCN enzymatic activity and Wnt inhibitor

CS-876

WNT C59; C59;WNTC59

Porcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem

Benzeneacetamide, 4-(2-methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]-

Wnt-C59 USP/EP/BP

1243243-89-1

Inhibitors

API