xav-939

Product Name: xav-939
CAS No.: 284028-89-3
Chemical Name: xav-939
Synonyms: XAV d;CS-300;xav-939;NVP-XAV 939;SteMolecule;XAV 939, >=98%;XAV-939;XAV 939;xav-939 USP/EP/BP;XAV 939/NVP-XAV939;XAV-939 284028-89-3
CBNumber: CB82501008
Molecular Formula: C14H11F3N2OS
Formula Weight: 312.31
MOL File: 284028-89-3.mol

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xav-939 Property

Boiling point:: 429.3±55.0 °C(Predicted)
Density: 1.5
Flash point:: 213.4℃
storage temp.: room temp
solubility: DMSO: soluble5mg/mL, clear
form: powder
pka: 0.23±0.20(Predicted)
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

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Safety

Hazard Codes: T
Risk Statements: 25-36
Safety Statements: 26-45-26/45
RIDADR: UN 2811
WGK Germany: 3
HazardClass: 6.1
PackingGroup: III
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: X3004
Product name: XAV 939
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Sigma-Aldrich

Product number: X3004
Product name: XAV 939
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $347
Updated: 2024/03/01

TCI Chemical

Product number: X0077
Product name: XAV 939
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $127
Updated: 2024/03/01

TCI Chemical

Product number: X0077
Product name: XAV 939
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $572
Updated: 2023/01/07

Cayman Chemical

Product number: 13596
Product name: XAV 939
Purity: ≥98%
Packaging: 1mg
Price: $15
Updated: 2024/03/01

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xav-939 Chemical Properties,Usage,Production

Description

XAV-939 (284028-89-3) is a tankyrase inhibitor (IC50=11 and 4 nM for TNKS1 and 2 respectively).? Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of actin.1? XAV-939 robustly induces cardiomyogenesis of stem cells.2? Cell permeable

Uses

A tankyrase (TNKS) inhibitor that antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. It inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.

Uses

XAV939 has been used in the inhibition

of tankyrase in neuroblastoma cell lines
of diphtheria toxin-like ADP-ribosyltransferases (ARTD) in medulloblastoma cells
of wnt signalling in human induced pluripotent stem cells (hiPSCs)

Definition

ChEBI: XAV939 is a thiopyranopyrimidine in which a 7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine skeleton is substituted at C-4 by a hydroxy group and at C-2 by a para-(trifluoromethyl)phenyl group. It has a role as a tankyrase inhibitor. It is a thiopyranopyrimidine and a member of (trifluoromethyl)benzenes.

Biochem/physiol Actions

XAV939 is a cell-permeable dihydrothiopyranopyrimidinol, which elicits anti-tumor functionality against colon, lung, breast and liver cancer. It binds to catalytic poly-ADP-ribose polymerase (PARP) domain of the tankyrase enzyme resulting in β-catenin destruction. It also inhibits tankyrase in neuroblastoma promoting apoptosis in tumor cells.

storage

Room temperature

References

1) Huang?et al. (2009),?Tankyrase inhibition stabilizes axin and antagonizes Wnt signaling; Nature,?46?614 2) Wang?et al. (2011),?Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling; Chem. Biol.,?6?192

xav-939 Preparation Products And Raw materials

Raw materials

Preparation Products

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xav-939 Suppliers

Canada 1 China 139 India 4 Japan 1 The Netherlands 1 United Kingdom 4 United States 23 Global 173

Shanghai Boyle Chemical Co., Ltd.

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Chemsky (shanghai) International Co.,Ltd

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Jinan Trio PharmaTech Co., Ltd.

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Dalian Meilun Biotech Co., Ltd.

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T&W GROUP

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284028-89-3, xav-939Related Search:

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xav-939

3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one

XAV 939/NVP-XAV939

CS-300

2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one

XAV 939, >=98%

SteMolecule

1,5,7,8-Tetrahydro-2-[4-(trifluoroMethyl)phenyl]-4H-thiopyrano[4,3-d]pyriMidin-4-one

NVP-XAV 939

2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol

XAV 939 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one

2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-3H-thiopyrano[4,3-d]pyrimidin-4(5H)-one

XAV-939;XAV 939

2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol

XAV-939, 98%, a selective Wnt pathway β-catenin-mediated transcription inhibitor

XAV d

4H-Thiopyrano[4,3-d]pyrimidin-4-one, 3,5,7,8-tetrahydro-2-[4-(trifluoromethyl)phenyl]-

xav-939 USP/EP/BP

2-(4-(Trifluoromethyl)phenyl)-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one

XAV-939 284028-89-3

poly ADP ribose polymerase,PARP,Inhibitor,β-catenin,inhibit,Beta catenin,XAV-939,XAV 939

2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-1H-thiopyrano[4,3-d]pyrimidin-4(5H)-one

284028-89-3

C14H11F3N2OS

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds

API

Aromatics