S-Trityl-L-cysteine

Product Name: S-Trityl-L-cysteine
CAS No.: 2799-07-7
Chemical Name: S-Trityl-L-cysteine
Synonyms: H-CYS(TRT)-OH;Dimethyl 5-bromopyridine-2,3-dicarboxylate;H-L-Cys(Trt)-OH;S-Tritylcysteine;H-Cys(Trt)-OH (Cys of Animal Origin);NSC 83265;L-Cys(Trt)-OH;EG5 INHIBITOR II;CYSTEINE(TRT)-OH;TRITYL-L-CYSTEINE
CBNumber: CB7164332
Molecular Formula: C22H21NO2S
Formula Weight: 363.47
MOL File: 2799-07-7.mol

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S-Trityl-L-cysteine Property

Melting point:: 182-183 °C (dec.)(lit.)
Boiling point:: 524.7±50.0 °C(Predicted)
Density: 1.1342 (rough estimate)
refractive index: 111 ° (C=0.8, 0.04mol Ethanolic HCl)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in DMSO (up to 20 mg/ml).
form: White to off-white solid.
pka: 2.22±0.10(Predicted)
color: White or off-white
optical activity: [α]25/D +115°, c = 0.8 in 0.04 M ethanolic HCl
BRN: 2339626
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
CAS DataBase Reference: 2799-07-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 22-24/25
WGK Germany: 3
RTECS: AY7710000
HS Code: 29309090
Toxicity: dog,LDLo,intravenous,150mg/kg (150mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),National Technical Information Service. Vol. PB81-109993,

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 164739
Product name: (+)-S-Trityl-L-cysteine
Purity: 97%
Packaging: 5g
Price: $185
Updated: 2024/03/01

TCI Chemical

Product number: T2522
Product name: S-Trityl-L-cysteine
Purity: >95.0%(T)
Packaging: 5g
Price: $49
Updated: 2024/03/01

Alfa Aesar

Product number: L14384
Product name: (+)-S-Trityl-L-cysteine
Purity: 97%
Packaging: 1g
Price: $25.2
Updated: 2023/06/20

Alfa Aesar

Product number: L14384
Product name: (+)-S-Trityl-L-cysteine
Purity: 97%
Packaging: 5g
Price: $57.6
Updated: 2023/06/20

Cayman Chemical

Product number: 23236
Product name: S-trityl-L-Cysteine
Purity: ≥98%
Packaging: 1g
Price: $25
Updated: 2024/03/01

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S-Trityl-L-cysteine Chemical Properties,Usage,Production

Description

S-Trityl-cysteine (2799-07-7) is a cell permeable inhibitor of mitotic kinesin Eg5 (IC50 for inhibition of basal ATPase activity = 1 μM; IC50 for inhibition of microtubule-activated ATPase activity = 140 nM). Mean growth concentration (GI50) of 1.31 μM for a panel of 60 different tumor cell lines.

Chemical Properties

almost white to light yellow granular powder

Uses

(+)-S-Trityl-L-cysteine, a non-natural, sulfur-containing amino acid is commonly used as a reagent in solution phase peptide synthesis (SPPS). It is also used as a metal-binding agent to synthesize substituted ferrocenoyl peptide conjugates using HBTU peptide coupling reagent for the cation-sensing applications solution via peptide-metal interactions.

Uses

A protected cysteine for peptide synthesis. S-Trityl-L-cysteine (STLC) is a tight-binding inhibitor of Eg5 that prevents mitotic progression. It has proven antitumor activity as shown in the NCI 60 tumor cell line screen.

Definition

ChEBI: (2R)-2-amino-3-[(triphenylmethyl)thio]propanoic acid is a benzenoid aromatic compound.

Biological Activity

Potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC 50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC 50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC 50 of 700 nM. Displays antitumor activity.

storage

Store at +4°C

References

1) DeBonis et al. (2004) In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumour activities; Mol. Cancer Ther. 3 1079 2) Brier et al. (2004) Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of mitotic kinesin Eg5; Biochemistry 43 13072 3) Skoufias et al. (2006) S-trityl-l-cysteine is a reversible, tight-binding inhibitor of the human kinesin eg5 that specifically blocks mitotic progression; J. Biol. Chem., 281 17559

S-Trityl-L-cysteine Preparation Products And Raw materials

Raw materials

Preparation Products

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S-Trityl-L-cysteine Suppliers

Belgium 1 Canada 1 China 166 Europe 1 Germany 5 India 7 Italy 1 Japan 7 South Korea 1 Switzerland 3 The Netherlands 1 United Kingdom 9 United States 56 Global 259

J & K SCIENTIFIC LTD.

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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Capot Chemical Co., Ltd

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Beijing Ouhe Technology Co., Ltd

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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

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View Lastest Price from S-Trityl-L-cysteine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: (+)-S-Trityl-L-cysteine 97% 2799-07-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: S-Trityl-L-cysteine 2799-07-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-15

2799-07-7, S-Trityl-L-cysteineRelated Search:

Triphenylmethyl Chloride S-Carboxymethyl-L-cysteine p-Toluic acid L-Cysteine Trityl candesartan cilexetil L-Cystine H-L-Cys(Trt)-OtBu*HCl N-[S-Trityl-L-cysteinyl]glycine L-Phenylalanine Fmoc-L-glutamic acid FMOC-LYS-OH Di-tert-butyl dicarbonate D-Tyrosine Nalpha-Fmoc-L-tyrosine L-Leucine FMOC-b-Ala-OH 9-Fluorenemethanol S-TRITYL-L-CYSTEINE AMIDE HYDROCHLORIDE

3-(tritylthio)-l-alanin

3-tritylthio-l-alanine

s-(triphenylmethyl)-l-cystein

H-Cys(Trt)-OH (Cys of Animal Origin)

H-Cys(Trt)-OH (Cys of Non Animal Origin)

L-Cys(Trt)-OH

S-Trityl-L-cysteine≥ 98% (HPLC)

H-CYS(TRT)-OH

CYSTEINE(TRT)-OH

EG5 INHIBITOR II

NSC 83265

S-(TRIPHENYLMETHYL)-L-CYSTEINE

(+)-S-TRITYL-L-CYSTEINE

(2R)-2-ammonio-3-[(triphenylmethyl)thio]propanoate

(2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoic acid

S-TRITYL-L-CYSTEINE

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S-TRITYL-L-CYSTEINE CRYSTALLINE

(+)-S-TRITYL-L-CYSTEINE 97%

L-Cysteine, -3,3-D2-S-Trityl

Dimethyl 5-bromopyridine-2,3-dicarboxylate

H-L-Cys(Trt)-OH

(R)-2-Amino-3-(tritylthio)propionic acid

(R)-S-Tritylcysteine

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(2R)-2-AMino-3-[(triphenylMethyl)thio]propanoic Acid

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Tritylthioalanine

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(R)-2-AMino-3-tritylsulfanyl-propionic acid

L-CYSTEINE, S-TRITYL

L-Cysteine, S-(triphenylmethyl)-

S-Trityl-L-cysteine USP/EP/BP

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Tritylthioalanine (H-Cys(Trt)-OH)

Impurity IIa-2 (S-triphenylmethylL-cysteine)

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328542

C6H53CSCD2CHNH2COOH

C6H53CSCH2CHNH2CO2H

Specialty Synthesis

Peptide Synthesis

Cysteine/Cystine

CARBOXYLIC ACID

Amino Acid Derivatives

Cell Cycle Regulation

Amino Acid Derivatives

Amino Acids & Derivatives

Aromatics

Chiral Reagents

Enzyme substrates