FMOC-b-Ala-OH
- Product Name
- FMOC-b-Ala-OH
- CAS No.
- 35737-10-1
- Chemical Name
- FMOC-b-Ala-OH
- Synonyms
- FMoc-β-Ala-OH;FMOC-BETA-ALA-OH;3-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)propanoic acid;FMoc-Beta-Ala;FMoc-B-Ala;Fmoc-β-alanine;N-Fmoc-β-alanine;-Ala-OH;-Ala-OPfp;FMOC-b-AL
- CBNumber
- CB9395385
- Molecular Formula
- C18H17NO4
- Formula Weight
- 311.34
- MOL File
- 35737-10-1.mol
FMOC-b-Ala-OH Property
- Melting point:
- 142-147 °C
- Boiling point:
- 451.38°C (rough estimate)
- Density
- 1.2626 (rough estimate)
- refractive index
- 1.5100 (estimate)
- storage temp.
- 2-8°C
- solubility
- Soluble in water or 1% acetic acid
- pka
- 4.41±0.10(Predicted)
- form
- powder to crystal
- color
- White to Almost white
- Water Solubility
- Soluble in water and 1% acetic acid.
- BRN
- 2302327
- CAS DataBase Reference
- 35737-10-1(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 2924 29 70
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 8.52024
- Product name
- FMOC-ß-ALA-OH
- Purity
- Novabiochem?
- Packaging
- 5G
- Price
- $54.6
- Updated
- 2025/07/31
- Product number
- 8.52024
- Product name
- FMOC-ß-ALA-OH
- Purity
- Novabiochem?
- Packaging
- 25g
- Price
- $207
- Updated
- 2025/07/31
- Product number
- 8.52024
- Product name
- FMOC-ß-ALA-OH
- Purity
- Novabiochem<SUP>®</SUP>
- Packaging
- 100 g
- Price
- $793
- Updated
- 2025/07/31
- Product number
- 8.52024
- Product name
- FMOC-ß-ALA-OH
- Purity
- Novabiochem<SUP>®</SUP>
- Packaging
- 100 g
- Price
- $793
- Updated
- 2025/07/31
- Product number
- 8.52024
- Product name
- FMOC-ß-ALA-OH
- Purity
- Novabiochem<SUP>®</SUP>
- Packaging
- 500 g
- Price
- $2270
- Updated
- 2025/07/31
FMOC-b-Ala-OH Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powde
Uses
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
Synthesis
28920-43-6
107-95-9
35737-10-1
Under stirring conditions, β-alanine (β-Ala, 0.5 g, 6.61 mmol) was dissolved in 10% aqueous Na2CO3 solution (12 ml) in a 50 ml flask. The flask was cooled in an ice bath followed by slow dropwise addition of Fmoc-Cl (1.45 g, 5.61 mmol) in dioxane (10 ml) solution. The reaction mixture was stirred continuously for 4 hours at room temperature. After completion of the reaction, the aqueous phase layer was separated by adding water (80 ml) for dilution and washed three times (75 ml each) with ether. The aqueous phase layer was acidified to pH=2 with 2N HCl aqueous solution and subsequently extracted with ethyl acetate three times (75 ml each). The organic phase layers were combined and concentrated to give 1.50 g of crude product. The crude product was recrystallized by a solvent mixture of ethyl acetate and hexane (1:2, 30 ml, v/v) and filtered under reduced pressure to obtain a white solid, Fmoc-β-Ala. yield: 1.41 g (81%). NMR (CDCl3) δ 2.6 (t, 2H, NHCH2CH2COOH), 3.47 (d, 2H, J = 7.0 Hz, NHCH2CH2COOH), 4.19 (t, 1H, J = 6.0 Hz, Fmoc-CH), 4.39 (d, 2H, J = 7.0 Hz, Fmoc-CH2), 7.29 (t, 2H , J = 7.3 Hz, Ar-H), 7.38 (t, 2H, J = 7.3 Hz, Ar-H), 7.56 (d, 2H, J = 7.0 Hz, Ar-H), 7.74 (d, 2H, J = 7.5 Hz, Ar-H).
References
[1] Tetrahedron, 1991, vol. 47, # 14-15, p. 2389 - 2400
[2] Patent: US2009/131681, 2009, A1. Location in patent: Page/Page column 3
[3] Journal of Organic Chemistry, 1972, vol. 37, # 22, p. 3404 - 3409
[4] Bioorganic Chemistry, 1996, vol. 24, # 1, p. 50 - 58
[5] Russian Journal of General Chemistry, 2010, vol. 80, # 12, p. 2572 - 2589
FMOC-b-Ala-OH Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from FMOC-b-Ala-OH manufacturers
- Product
- Fmoc-β-Ala-OH 35737-10-1
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-23
- Product
- FMOC-beta-Ala-OH 35737-10-1
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 500kgs
- Release date
- 2021-09-26
- Product
- Fmoc-β-Ala-OH 35737-10-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T
- Release date
- 2023-12-13