FMOC-L-Methionine

Product Name: FMOC-L-Methionine
CAS No.: 71989-28-1
Chemical Name: FMOC-L-Methionine
Synonyms: Fmoc-Met-OH;FMOC-MET;FMOC-L-MET-OH;N-Fmoc-L;FMOC-L-MET;N-FMOC-L-MET;N-FMOC-MET-OH;FMOC-METHIONINE;N-Fmoc-L-Met-OH;FMOC-MET-OH 25 G
CBNumber: CB3304389
Molecular Formula: C20H21NO4S
Formula Weight: 371.45
MOL File: 71989-28-1.mol

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FMOC-L-Methionine Property

Melting point:: 121-123 °C(lit.)
alpha: -29 º (c=1,DMF 24 ºC)
Boiling point:: 614.6±55.0 °C(Predicted)
Density: 1.2053 (rough estimate)
refractive index: -29.5 ° (C=1, DMF)
storage temp.: 2-8°C
solubility: very faint turbidity in Methanol
pka: 3.72±0.10(Predicted)
form: Granular Powder
color: White
optical activity: [α]20/D -29.5±1.5°, c = 1% in DMF
BRN: 4300266
InChI: InChI=1S/C20H21NO4S/c1-26-11-10-18(19(22)23)21-20(24)25-12-17-15-8-4-2-6-13(15)14-7-3-5-9-16(14)17/h2-9,17-18H,10-12H2,1H3,(H,21,24)(H,22,23)/t18-/m0/s1
InChIKey: BUBGAUHBELNDEW-SFHVURJKSA-N
SMILES: C(O)(=O)[C@H](CCSC)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference: 71989-28-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-36/37/39-27-26
WGK Germany: 3
HS Code: 2930 90 98

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52002
Product name: Fmoc-Met-OH
Purity: Novabiochem?
Packaging: 25g
Price: $37.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52002
Product name: Fmoc-Met-OH
Purity: Novabiochem?
Packaging: 100g
Price: $71.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52002
Product name: Fmoc-Met-OH
Purity: Novabiochem?
Packaging: 250g
Price: $166
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52002
Product name: Fmoc-Met-OH
Purity: Novabiochem<SUP>®</SUP>
Packaging: 500 g
Price: $209.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52002
Product name: Fmoc-Met-OH
Purity: Novabiochem<SUP>®</SUP>
Packaging: 500 g
Price: $209.3
Updated: 2025/07/31

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FMOC-L-Methionine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

N-Fmoc-L-methionine is an N-Fmoc-protected form of L-Methionine (M260440). L-Methionine is an essential amino acid that is obtained from our diet. L-Methionine can be found in grain legumes (such as lentils), and poultry. L-Methionine’s main function is to act as the primary “Start” sequence on mRNA so that the ribosomes can start translating the mRNA into proteins.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

63-68-3

82911-69-1

71989-28-1

Synthesis of Fmoc-L-methionine: 6 mmol of L-methionine and 6.3 mmol of 9-fluorenylmethyl-N-succinimidyl carbonate (Fmoc-OSu) were dissolved in 20 mL of N,N-dimethylformamide (DMF). Subsequently, 6.3 mmol of sodium bicarbonate (NaHCO3) was added to the reaction mixture to neutralize the acid produced during the reaction and to remove the solvent and residual amines. The reaction mixture was stirred at 50 °C overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified to afford the target compound Fmoc-L-methionine in 78% yield.

References

[1] Patent: CN105622471, 2016, A. Location in patent: Paragraph 0019; 0020
[2] Synthetic Communications, 2009, vol. 39, # 11, p. 2022 - 2031
[3] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 13, p. 2980 - 2983

FMOC-L-Methionine Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-L-Methionine Suppliers

Americas 1 Belgium 1 Canada 2 China 354 Europe 5 France 2 Germany 6 Hungary 1 India 28 Israel 2 Italy 2 Japan 8 Switzerland 6 United Kingdom 17 United States 69 Global 504

GenChem & GenPharm (Changzhou) Co., Ltd.

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View Lastest Price from FMOC-L-Methionine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-L-Met-OH 71989-28-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-12-06

Henan Aochuang Chemical Co.,Ltd.

Product: FMOC-L-Methionine 71989-28-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-12

Dingwang Technology (Wuhan) Co., Ltd.

Product: Fmoc-Met-OH 71989-28-1
Price: US $0.00/gram
Min. Order: 100gram
Purity: 99% HPLC
Supply Ability: 25 gram
Release date: 2023-10-16

71989-28-1, FMOC-L-MethionineRelated Search:

1,1'-Carbonyldiimidazole DL-Methionine CARBONYL SULFIDE L-Fmoc-Aspartic acid alpha-tert-butyl ester Fmoc-Lys(Boc)-OH Zinc methionine sulfate Fmoc-Aib-OH Fmoc-Asp(OtBu)-OH 9-Fluorenylmethyl chloroformate Fmoc-Phe-OH L-Methionine Fmoc-Pro-OH Fmoc-OSu Fmoc-L-glutamic acid FMOC-L-Valine Fmoc-L-glutamic acid-gamma-benzyl ester Fmoc-L-hydroxyproline FMOC-CHG-OH

FMOC-L-MET

FMOC-L-METHIONINE

FMOC-L-MET-OH

N-ALPHA-FMOC-L-METHIONINE

N-(9-FLUORENYLMETHOXYCARBONYL)-L-METHIONINE

N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-METHIONINE

N-9-FLUORENYLMETHYLOXYCARBONYL-L-METHIONINE

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-METHIONINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-METHIONINE

N-FLUORENYLMETHOXYCARBONYL-L-METHIONINE

N-FMOC-MET-OH

N-FMOC-L-MET

N-FMOC-L-METHIONINE

FMOC-METHIONINE

N-Fmoc-L-methionine Fmoc-Met-OH

(S)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-4-(Methylthio)butanoic acid

L-METHIONINE-N-FMOC (1-13C)

L-METHIONINE-N-FMOC (13C5,15N)

L-METHIONINE-N-FMOC (15N)

L-METHIONINE-N-FMOC (METHYL-13C)

Fmoc-Met-OH >=98.0% (HPLC)

Fmoc-L-methionine≥ 99% (HPLC)

(9H-Fluoren-9-yl)MethOxy]Carbonyl Met-OH

(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-(methylsulfanyl)butanoic acid

FMOC-MET

9-FLUORENYLMETHOXYCARBONYL-L-METHIONINE

FMOC-L-METHIONINE 98%

L-Methionine-N-FMOC-UL-13C5, 15N

N-(9-FLUORENYLMETHOXYCARBONYL)-L-METHIONINE(FMOC-L-MET-OH)

Fmoc-Met-OH

L-Methionine/DL-Methionine

FMOC-L-METHIONINE extrapure

2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanylbutanoic acid

L-Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

N-(9-Fluorenylmethoxycarbonyl)-L-methionine ,98%

Fmoc-S-Methyl-Hcy-OH

N-(9H-Fluorene-9-ylmethoxycarbonyl)-S-methyl-L-homocysteine

N-Fmoc-L-Met-OH

N-Fmoc-L-methionine, 98+%

FMOC-L-Methionine,98%

N-[(9H-Fluoren-9-ylmethoxycarbonyl]-L-Methionine(Fmoc-L-Met-OH)

Fmoc-Methionine-OH

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-methionine&gt

FMOC-MET-OH 100 G

FMOC-MET-OH 25 G

FMOC-MET-OH 250 G

N-Fmoc-L

FMOC-L-Methionine USP/EP/BP

N-Fmoc-L-Methionine-34S

N-(9-Fluorenyl methoxy carbonyl)methionine

71989-28-1

71898-28-1

CH3SCH2CH2CHNHFMOCCOOH

C20H20NO4S

Amino Acid Derivatives

Fmoc-Amino Acids

Amino Acids (N-Protected)

Protected & Labeled Amino Acids