ChemicalBook > CAS DataBase List > FMOC-L-Methionine

FMOC-L-Methionine

Product Name
FMOC-L-Methionine
CAS No.
71989-28-1
Chemical Name
FMOC-L-Methionine
Synonyms
Fmoc-Met-OH;FMOC-MET;FMOC-L-MET-OH;N-Fmoc-L;FMOC-L-MET;N-FMOC-L-MET;N-FMOC-MET-OH;FMOC-METHIONINE;N-Fmoc-L-Met-OH;FMOC-MET-OH 25 G
CBNumber
CB3304389
Molecular Formula
C20H21NO4S
Formula Weight
371.45
MOL File
71989-28-1.mol
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FMOC-L-Methionine Property

Melting point:
121-123 °C(lit.)
alpha 
-29 º (c=1,DMF 24 ºC)
Boiling point:
614.6±55.0 °C(Predicted)
Density 
1.2053 (rough estimate)
refractive index 
-29.5 ° (C=1, DMF)
storage temp. 
2-8°C
solubility 
very faint turbidity in Methanol
pka
3.72±0.10(Predicted)
form 
Granular Powder
color 
White
optical activity
[α]20/D -29.5±1.5°, c = 1% in DMF
BRN 
4300266
InChI
InChI=1S/C20H21NO4S/c1-26-11-10-18(19(22)23)21-20(24)25-12-17-15-8-4-2-6-13(15)14-7-3-5-9-16(14)17/h2-9,17-18H,10-12H2,1H3,(H,21,24)(H,22,23)/t18-/m0/s1
InChIKey
BUBGAUHBELNDEW-SFHVURJKSA-N
SMILES
C(O)(=O)[C@H](CCSC)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference
71989-28-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36/37/39-27-26
WGK Germany 
3
HS Code 
2930 90 98
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.52002
Product name
Fmoc-Met-OH
Purity
Novabiochem?
Packaging
25g
Price
$37.5
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52002
Product name
Fmoc-Met-OH
Purity
Novabiochem?
Packaging
100g
Price
$71.9
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52002
Product name
Fmoc-Met-OH
Purity
Novabiochem?
Packaging
250g
Price
$166
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52002
Product name
Fmoc-Met-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
500 g
Price
$209.3
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52002
Product name
Fmoc-Met-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
500 g
Price
$209.3
Updated
2025/07/31
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FMOC-L-Methionine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

N-Fmoc-L-methionine is an N-Fmoc-protected form of L-Methionine (M260440). L-Methionine is an essential amino acid that is obtained from our diet. L-Methionine can be found in grain legumes (such as lentils), and poultry. L-Methionine’s main function is to act as the primary “Start” sequence on mRNA so that the ribosomes can start translating the mRNA into proteins.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

63-68-3

82911-69-1

71989-28-1

Synthesis of Fmoc-L-methionine: 6 mmol of L-methionine and 6.3 mmol of 9-fluorenylmethyl-N-succinimidyl carbonate (Fmoc-OSu) were dissolved in 20 mL of N,N-dimethylformamide (DMF). Subsequently, 6.3 mmol of sodium bicarbonate (NaHCO3) was added to the reaction mixture to neutralize the acid produced during the reaction and to remove the solvent and residual amines. The reaction mixture was stirred at 50 °C overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified to afford the target compound Fmoc-L-methionine in 78% yield.

References

[1] Patent: CN105622471, 2016, A. Location in patent: Paragraph 0019; 0020
[2] Synthetic Communications, 2009, vol. 39, # 11, p. 2022 - 2031
[3] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 13, p. 2980 - 2983

FMOC-L-Methionine Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-L-Methionine Suppliers

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View Lastest Price from FMOC-L-Methionine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Fmoc-L-Met-OH 71989-28-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2023-12-06
Henan Aochuang Chemical Co.,Ltd.
Product
FMOC-L-Methionine 71989-28-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-12
Dingwang Technology (Wuhan) Co., Ltd.
Product
Fmoc-Met-OH 71989-28-1
Price
US $0.00/gram
Min. Order
100gram
Purity
99% HPLC
Supply Ability
25 gram
Release date
2023-10-16

71989-28-1, FMOC-L-MethionineRelated Search:

1,1'-Carbonyldiimidazole DL-Methionine CARBONYL SULFIDE L-Fmoc-Aspartic acid alpha-tert-butyl ester Fmoc-Lys(Boc)-OH Zinc methionine sulfate Fmoc-Aib-OH Fmoc-Asp(OtBu)-OH 9-Fluorenylmethyl chloroformate Fmoc-Phe-OH L-Methionine Fmoc-Pro-OH Fmoc-OSu Fmoc-L-glutamic acid FMOC-L-Valine Fmoc-L-glutamic acid-gamma-benzyl ester Fmoc-L-hydroxyproline FMOC-CHG-OH

  • FMOC-L-MET
  • FMOC-L-METHIONINE
  • FMOC-L-MET-OH
  • N-ALPHA-FMOC-L-METHIONINE
  • N-(9-FLUORENYLMETHOXYCARBONYL)-L-METHIONINE
  • N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-METHIONINE
  • N-9-FLUORENYLMETHYLOXYCARBONYL-L-METHIONINE
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-METHIONINE
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-METHIONINE
  • N-FLUORENYLMETHOXYCARBONYL-L-METHIONINE
  • N-FMOC-MET-OH
  • N-FMOC-L-MET
  • N-FMOC-L-METHIONINE
  • FMOC-METHIONINE
  • N-Fmoc-L-methionine Fmoc-Met-OH
  • (S)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-4-(Methylthio)butanoic acid
  • L-METHIONINE-N-FMOC (1-13C)
  • L-METHIONINE-N-FMOC (13C5,15N)
  • L-METHIONINE-N-FMOC (15N)
  • L-METHIONINE-N-FMOC (METHYL-13C)
  • Fmoc-Met-OH >=98.0% (HPLC)
  • Fmoc-L-methionine≥ 99% (HPLC)
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl Met-OH
  • (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-(methylsulfanyl)butanoic acid
  • FMOC-MET
  • 9-FLUORENYLMETHOXYCARBONYL-L-METHIONINE
  • FMOC-L-METHIONINE 98%
  • L-Methionine-N-FMOC-UL-13C5, 15N
  • N-(9-FLUORENYLMETHOXYCARBONYL)-L-METHIONINE(FMOC-L-MET-OH)
  • Fmoc-Met-OH
  • L-Methionine/DL-Methionine
  • FMOC-L-METHIONINE extrapure
  • 2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanylbutanoic acid
  • L-Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
  • N-(9-Fluorenylmethoxycarbonyl)-L-methionine ,98%
  • Fmoc-S-Methyl-Hcy-OH
  • N-(9H-Fluorene-9-ylmethoxycarbonyl)-S-methyl-L-homocysteine
  • N-Fmoc-L-Met-OH
  • N-Fmoc-L-methionine, 98+%
  • FMOC-L-Methionine,98%
  • N-[(9H-Fluoren-9-ylmethoxycarbonyl]-L-Methionine(Fmoc-L-Met-OH)
  • Fmoc-Methionine-OH
  • N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-methionine&gt
  • FMOC-MET-OH 100 G
  • FMOC-MET-OH 25 G
  • FMOC-MET-OH 250 G
  • N-Fmoc-L
  • FMOC-L-Methionine USP/EP/BP
  • N-Fmoc-L-Methionine-34S
  • N-(9-Fluorenyl methoxy carbonyl)methionine
  • 71989-28-1
  • 71898-28-1
  • CH3SCH2CH2CHNHFMOCCOOH
  • C20H20NO4S
  • Amino Acid Derivatives
  • Fmoc-Amino Acids
  • Amino Acids (N-Protected)
  • Protected & Labeled Amino Acids