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Fmoc-Asp(OtBu)-OH

Product Name
Fmoc-Asp(OtBu)-OH
CAS No.
71989-14-5
Chemical Name
Fmoc-Asp(OtBu)-OH
Synonyms
FMOC-ASP(OTBU)-OH;FMOC-ASP(TBU)-OH;(S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-4-(tert-butoxy)-4-oxobutanoic acid;FMOC-L-ASP(OTBU)-OH;FMOC-ASP(OBUT);Fomc-Asp(OtBu)-OH;FMOC-L-ASP(TBU)-OH;Fomc-Asp(O;cas:71989-14-5;Fmoc-(tBu)Asp-OH
CBNumber
CB2143480
Molecular Formula
C23H25NO6
Formula Weight
411.45
MOL File
71989-14-5.mol
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Fmoc-Asp(OtBu)-OH Property

Melting point:
148-150 °C (dec.)
Boiling point:
530.45°C (rough estimate)
alpha 
-25 º (c=1,DMF 24 ºC)
Density 
1.2498 (rough estimate)
refractive index 
-25 ° (C=1, DMF)
storage temp. 
2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka
3.57±0.23(Predicted)
form 
powder to crystal
color 
White to Almost white
optical activity
[α]20/D 24±2°, c = 1% in DMF
Water Solubility 
Slightly soluble in water.
BRN 
3635671
InChIKey
FODJWPHPWBKDON-IBGZPJMESA-N
CAS DataBase Reference
71989-14-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36/37/39-27-26
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.52005
Product name
Fmoc-Asp(OtBu)-OH
Purity
Novabiochem?
Packaging
25g
Price
$74.8
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52005
Product name
Fmoc-Asp(OtBu)-OH
Purity
Novabiochem?
Packaging
100g
Price
$225
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52005
Product name
Fmoc-Asp(OtBu)-OH
Purity
Novabiochem?
Packaging
250g
Price
$480
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52005
Product name
Fmoc-Asp(OtBu)-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
500 g
Price
$628.6
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52005
Product name
Fmoc-Asp(OtBu)-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
500 g
Price
$628.6
Updated
2025/07/31
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Fmoc-Asp(OtBu)-OH Chemical Properties,Usage,Production

Chemical Properties

Fmoc-Asp(OtBu)-OH is a protected form of L-aspartic acid. It is a white to light yellow crystal powder. The molecule contains ester groups and amino groups, making it prone to polymerization and unstable over time. Therefore, it is not recommended to store it for extended periods.

Uses

L-Aspartic acid is a nonessential amino acid that is used to biosynthesize other amino acids within the human body.

Preparation

Fmoc-Asp(OtBu)-OH was prepared by substitution reaction with 9-fluorenylmethyl chloroformate from L-aspartic acid 4-tert-butyl ester.

General Description

Fmoc-Asp(OtBu)-OH is a white to off-white solid, it can be used for peptide synthesis.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

144120-52-5

71989-14-5

The general procedure for the synthesis of Fmoc-L-aspartic acid β-tert-butyl ester from the compound (CAS:144120-52-5) was as follows: firstly, PdEnCat 30 (Aldrich; loading 0.4 mmol/g, use 0.05 eq.) was suspended in THF-H2O (9:1 v/v, total 5 mL) and treated with argon bubbling for 10 min for deoxygenation. Subsequently, DCHT (0.15 eq.) and the corresponding ester 1 (1.0 eq., 70 mg) were added under positive pressure. Finally, PhSiH3 (2.0 eq.) was injected and the reaction mixture was allowed to react at room temperature for 2 h. The reaction was carried out under low pressure. After completion of the reaction, the mixture was filtered through Celite and the filtrate was concentrated under reduced pressure. The residual solid was dissolved with EtOAc (20 mL) and washed sequentially with H2O (3 x 10 mL) and brine (3 x 10 mL). The organic layer was dried over MgSO4 and concentrated in vacuum. Purification was carried out by solid phase extraction (using C18 reversed-phase chromatography with H2O/MeOH as eluent) to obtain pure carboxylic acid 2 (see Table 1 for yields). The purity of the products was confirmed analytically by HPLC, 1H NMR and 13C NMR. All the carboxylic acids were commercially available. The 1H and 13C NMR spectra of the synthesized compounds were in agreement with those of commercial samples.

References

[1] Synlett, 2014, vol. 25, # 16, p. 2319 - 2322

Fmoc-Asp(OtBu)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-Asp(OtBu)-OH Suppliers

Americas 1 Belgium 1 Canada 3 China 420 Europe 5 France 2 Germany 7 India 13 Italy 2 Japan 7 Poland 1 Switzerland 6 United Kingdom 16 United States 64 Global 548
SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD
Tel
0838-2809458 13350585791
Email
pharm@biots.cn
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China
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587
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Lanxi Xingnuo Import and Export Trading Co., Ltd
Tel
0579-8831088 15888978871
Email
994350525@qq.com
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China
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GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
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Gill polypeptide biopharmaceutical (dalian) co., LTD
Tel
021-61263455 13167021076
Email
amy@glschina.com
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China
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9737
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Chengdu Baishixing Science and Technology Industry Co.,Ltd
Tel
13668201230
Fax
028-88530181
Email
yuanjun@cd-bsx.com
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China
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55
Chengdu Tachem Co., Ltd
Tel
19983060238
Email
sales@tachem.cn
Country
China
ProdList
103
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58
Nanjing Yuanpeptide Biotech Co.，Ltd.
Tel
18168071971
Email
support@yuan-peptide.com
Country
China
ProdList
2983
Advantage
58
Shandong fen Boyu Biotechnology Co.,LTD
Tel
13356310019 13356310019;
Email
boyu2024@163.com
Country
China
ProdList
3247
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GenChem & GenPharm (Changzhou) Co., Ltd.
Tel
0519-85720003 18861157602
Fax
0519-85720007
Email
410649415@qq.com
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China
ProdList
111
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Hubei Hengluyuan Technology Co., Ltd.
Tel
027-027-88188016 18062414339
Fax
+86-02788188026
Email
1764683941@qq.com
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China
ProdList
479
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View Lastest Price from Fmoc-Asp(OtBu)-OH manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
Fmoc-Asp(OtBu)-OH 71989-14-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2025-10-24
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Fmoc-Asp(OtBu)-OH 71989-14-5
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kg
Release date
2021-08-28
Henan Aochuang Chemical Co.,Ltd.
Product
FMOC-L-Aspartic acid beta-tert-butyl ester 71989-14-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-12

71989-14-5, Fmoc-Asp(OtBu)-OHRelated Search:

L-Aspartic acid Fmoc-L-aspartic acid Fmoc-Aib-OH Tris(trimethylsilyl)phosphate Butyl acetate L-Fmoc-Aspartic acid alpha-tert-butyl ester 9-Fluorenylmethyl chloroformate L-ASPARTIC ACID FMOC-ASN(TRT)-OPFP 2-Butoxyethanol Buprofezin Poly-L-aspartic acid Butyl acrylate Fmoc-OSu FMOC-S-trityl-L-cysteine Fmoc-Trp(Boc)-OH Nalpha-Fmoc-Ndelta-trityl-L-glutamine Fmoc-Tyr(tBu)-OH

  • Fmoc-(tBu)Asp-OH
  • cas:71989-14-5
  • Fmoc-L-aspartic acid β-tert-butyl ester≥ 99.7% (HPLC, Chiral purity)
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-ASPARTIC ACID BETA-T-BUTYL ESTER
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-ASPARTIC ACID BETA-TERT-BUTYL ESTER
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-ASPARTIC ACID BETA-T-BUTYL ESTER
  • N-9-FLUORENYLMETHYLOXYCARBONYL-L-ASPARTIC ACID BETA-T-BUTYL ESTER
  • N-9-FLUORENYLMETHYLOXYCARBONYL-L-ASPARTIC ACID BETA-TERT-BUTYL ESTER
  • N-(9-FLUORENYLMETHOXYCARBONYL)-L-ASPARAGIN ACID BETA-T-BUTYL ESTER
  • N-(9-Fluorenylmethoxycarbonyl)-L-aspartic acid beta-tert-butyl ester
  • N-ALPHA-FMOC-L-ASPARTIC ACID BETA-T-BUTYL ESTER
  • N-ALPHA-FMOC-L-ASPARATIC ACIDBETA-TERT-BUTYL ESTER
  • N-ALPHA-FMOC-L-ASPARTIC ACID BETA-TERT-BUTYL ESTER
  • N-ALPHA-FMOC-O-T-BUTYL-L-ASP
  • FMOC-ASP(TBU)-OH
  • FMOC-L-ASPARTIC ACID B-TERT-BUTYL ESTER
  • NALPHA-9-Fluorenylmethoxycarbonyl-L-aspartic acid B-tert- butyl ester
  • N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-ASPARTIC ACID-4-TERT-BUTYL ESTER
  • Fmoc-L-aspartic acid -t-butyl ester
  • N-α-Fmoc-L-aspartic acid β-tert butyl ester
  • L-Aspartic Acid-15N-β-O-t-Butyl Ester-N-FMOC
  • 4-tert-Butyl N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartate
  • 4-tert-Butyl N-Fmoc-L-aspartate
  • N-Fmoc-L-aspartic Acid 4-tert-Butyl Ester
  • N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid butyl ester
  • 2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoic acid
  • L-Aspartic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 4-(1,1-dimethylethyl) ester
  • N-(9-Fluorenylmethoxycarbonyl)aspartic acid 4-tert-butyl ester
  • N-(9-Fluorenylmethoxycarbonyl)-L-aspartic acid b-tert-butyl ester
  • N-(9-Fluorenylmethyloxycarbonyl)-L-aspartic acid 4-tert-butyl ester ,98%
  • FMOC-L-ASPARTIC ACID-BETA-TERT-BUTYLESTER 98%
  • (S)-2-[(9H-Fluorene-9-yl)methoxycarbonylamino]succinic acid 4-tert-butyl ester
  • (S)-4-Oxo-4-tert-butoxy-2-[(9H-fluorene-9-ylmethoxycarbonyl)amino]butanoic acid
  • N-(9H-Fluorene-9-ylmethoxycarbonyl)-3-(tert-butyloxycarbonyl)-L-alanine
  • N-(9H-Fluorene-9-ylmethoxycarbonyl)-4-oxo-O-tert-butyl-L-homoserine
  • N-(9H-Fluorene-9-ylmethoxycarbonyl)-L-aspartic acid 4-tert-butyl ester
  • (2S)-4-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-keto-butyric acid
  • (2S)-4-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-butanoic acid
  • (2S)-4-tert-butoxy-2-[(9H-fluoren-9-ylmethoxy-oxomethyl)amino]-4-oxobutanoic acid
  • L-Aspartic Acid-N-FMOC,β-O-t-Butyl Ester-UL-13C4, 15N
  • 4-tert-butoxy-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-oxobutanoic acid
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl Asp(OtBu)-OH
  • Fomc-Asp(O
  • Fomc-Asp(OtBu)-OH
  • Fmoc-Asparticacidα-t-butylester
  • 9-FLUORENYLMETHOXYCARBONYL-L-ASPARTIC ACID BETA-T-BUTYL ESTER
  • FMOC-L-ASP(TBU)-OH
  • Fmoc-L-Aspartic acid beta-tert-butyl ester
  • FMOC-L-ASPARTIC ACID B-T-BUTYL ESTER
  • FMOC-L-ASPARTIC ACID (OTBU)
  • FMOC-L-ASPARTIC ACID(O-T-BUTYL)
  • FMOC-L-ASP(OTBU)-OH
  • FMOC-L-ASP(O-T-BUTYL)
  • FMOC-L-ASPARTIC ACID 4-TERT-BUTYL ESTER
  • FMOC-L-ASPARTIC ACID BETA-T-BUTYL ESTER
  • FMOC-L-ASPARAGIN ACID BETA-T-BUTYL ESTER
  • FMOC-L-ASPARAGIN ACID BETA-TERT-BUTYL ESTER
  • FMOC-ASPARTIC ACID(OTBU)