Fmoc-Tyr(tBu)-OH

Product Name: Fmoc-Tyr(tBu)-OH
CAS No.: 71989-38-3
Chemical Name: Fmoc-Tyr(tBu)-OH
Synonyms: FMOC-TYR(TBU)-OH;FMOC-TYR(TBU);Fmoc-Tyr(otbu)-OH;Tyr(tBu);FMOC-L-TYR(TBU)-OH;FMOC-TYR(TRT)-OH;FMOC-TYR(BUT);FMOC-L-TYROSINE(O-T-BUTYL);FMOC-L-TYR(TBU)-OH(71989-38-3);(2S)-3-[4-(tert-butoxy)phenyl]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CBNumber: CB5854161
Molecular Formula: C28H29NO5
Formula Weight: 459.53
MOL File: 71989-38-3.mol

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Fmoc-Tyr(tBu)-OH Property

Melting point:: ~150 °C (dec.)
alpha: -28 º (c=1, DMF)
Boiling point:: 658.2±55.0 °C(Predicted)
Density: 1.218±0.06 g/cm3(Predicted)
refractive index: -30 ° (C=1, DMF)
storage temp.: Store below +30°C.
solubility: Chloroform (Slightly), DMF (Slightly), Methanol (Slightly)
form: Powder
pka: 2.97±0.10(Predicted)
color: White
optical activity: [α]20/D 29±2°, c = 1% in DMF
BRN: 4216652
InChIKey: JAUKCFULLJFBFN-VWLOTQADSA-N
SMILES: C(O)(=O)[C@H](CC1=CC=C(OC(C)(C)C)C=C1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference: 71989-38-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-24/25
WGK Germany: 3
HS Code: 2924 29 70

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52020
Product name: Fmoc-Tyr(tBu)-OH
Purity: Novabiochem?
Packaging: 25g
Price: $90.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.52020
Product name: Fmoc-Tyr(tBu)-OH
Purity: Novabiochem?
Packaging: 100g
Price: $326
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.52020
Product name: Fmoc-Tyr(tBu)-OH
Purity: Novabiochem?
Packaging: 250g
Price: $687
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.52020
Product name: Fmoc-Tyr(tBu)-OH
Purity: Novabiochem?
Packaging: 1kg
Price: $2360
Updated: 2024/03/01

Sigma-Aldrich

Product number: 47623
Product name: Fmoc-Tyr(tBu)-OH
Purity: ≥98.0% (HPLC)
Packaging: 10g
Price: $65.9
Updated: 2024/03/01

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Fmoc-Tyr(tBu)-OH Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline powder; insoluble in water and petroleum ether, soluble in ethyl acetate, methanol and DMF; mp is 150-151°C; specific optical rotation [α] 20D + 5.2° (0.5-2.0mg/ml, ethyl acetate ), [α]20D-27.6° (0.5-2.0 mg/ml, DMF), [α]20D-6° (0.5-2.0 mg/ml, methanol).

Uses

Fmoc-O-tert-butyl-L-tyrosine belongs to L-tyrosine compounds. Its molecular structure contains a chiral center, so it can exist two enantiomers and has optical activity. Fmoc-Tyr(tBu)-OH is used in peptide synthesis as amino acid protection monomer.

Preparation

To obtain Fmoc-Tyr(tBu)-OH, the following steps are carried out:
Suspend O-tert-butyl-L-tyrosine in a solution of dioxane.
Conduct an acylation reaction with fluorenyl methaneoxycarbonyl azide.
After the reaction, extract the crude product with ethyl acetate under pH 9-10 conditions.
Purify the extracted product through recrystallization.
This process results in the final product, Fmoc-Tyr(tBu)-OH.

General Description

Fmoc-Tyr(tBu)-OH is the preferred tyrosine derivative for solid phase peptide synthesis by Fmoc protocols. Protecting the Tyr sidechain may not be essential in the synthesis of small peptides. If the phenolic functional group of tyrosine does become acylated during a coupling reaction, the subsequent treatment with piperdine to remove Fmoc-groups will also remove any acylation of the phenolic function. Using Fmoc-Tyr(tBu)-OH in peptide synthesis is more efficient, however, since none of the activated amino acids are used unproductively in acylating exposed tyrosine side-chains. The use of Fmoc-Tyr(tBu)-OH also eliminates all potential for side products arising from the acylation of the tyrosine side-chain.

Fmoc-Tyr(tBu)-OH Preparation Products And Raw materials

Raw materials

Fluorene 1,4-Dioxane O-tert-Butyl-L-tyrosine

Preparation Products

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Fmoc-Tyr(tBu)-OH Suppliers

Americas 1 Canada 2 China 360 Europe 6 France 2 Germany 6 India 16 Israel 1 Japan 8 Poland 1 Switzerland 6 United Kingdom 19 United States 65 Global 493

SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD

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J & K SCIENTIFIC LTD.

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View Lastest Price from Fmoc-Tyr(tBu)-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-L-Tyr(tBu)-OH 71989-38-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-12-11

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Fmoc-O-tert-butyl-L-tyrosine 71989-38-3
Price: US $0.00/Kg/Bag
Min. Order: 10g
Purity: 98%min
Supply Ability: 100kgs
Release date: 2021-10-15

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Fmoc-Tyr(tBu)-OH 71989-38-3
Price: US $0.00/gram
Min. Order: 25gram
Purity: 99% HPLC
Supply Ability: 25 gram
Release date: 2023-10-16

71989-38-3, Fmoc-Tyr(tBu)-OHRelated Search:

tert-Butyl methyl ether 4-tert-Butylphenol H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH L-Tyrosine 2-Butoxyethanol Buprofezin Butyl acrylate Butyl acetate TYROSINASE butyl rubber Fmoc-Aib-OH Cyhalofop-butyl 9-Fluorenylmethyl chloroformate PYRAZOPHOS tert-Butyldimethylsilyl chloride Methyl 4-tert-butylbenzoate tert-Butyl hydroperoxide Nalpha-Fmoc-L-tyrosine

FMOC-L-TYR(TBU)-OH(71989-38-3)

(2S)-3-[4-(tert-butoxy)phenyl]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid

FMOC-L-TYROSINE(O-T-BUTYL)

FMOC-L-TYROSINE (TBU)

o-(tert-butyl)-n-[(9h-fluoren-9-ylmethoxy)carbonyl]-l-tyrosine

O-TERT-BUTYL-NALPHA-FMOC-L-TYROSINE

N-FMOC-T-BUTYL-L-TYR

N-FMOC-O-T-BUTYL-L-TYROSINE

N-ALPHA-FMOC-O-T-BUTYL-L-TYROSINE

NALPHA-FMOC-O-TERT-BUTYL-L-TYROSINE

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-T-BUTYL-L-TYROSINE

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-TERT-BUTYL-L-TYROSINE

NALPHA-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-O-TERT-BUTYL-L-TYROSINE

N-(9-FLUORENYLMETHOXYCARBONYL)-O-TERT-BUTYL-L-TYROSINE

N-9-FLUORENYLMETHYLOXYCARBONYL-O-T-BUTYL-L-TYROSINE

N-9-FLUORENYLMETHYLOXYCARBONYL-O-TERT-BUTYL-L-TYROSINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-T-BUTYL-L-TYROSINE

9-FLUORENYLMETHOXYCARBONYL-O-T-BUTYL-L-TYROSINE

L-Tyrosine-UL-13C9, 15N-N-FMOC

N-(9-FLUORENYLMETHOXYCARBONYL)-2-TERT-BUTYL-L-TYROSINE

NALPHA-9-Fluorenylmethoxycarbonyl-O-tert-butyl-L-tyrosine

N-A-FMOC-O-T-BUTYL-L-TYROSINE

FMOC-O-T-BUTYL-L-TYROSINE (FMOC-L-TYR(TBU)-OH)

FMOC-O-TERT-BUTYL-L-TYROSINE 98+%

N-tert-Butoxycarbonyl-O-(2-bromo-Cbz)-L-tyrosine

L-TYROSINE-N-FMOC, O-TERT-BUTYL ETHER (13C9,15N)

Fmoc-Tyr(otbu)-OH

(9H-Fluoren-9-yl)MethOxy]Carbonyl Tyr(tBu)-OH

Fomc-Tyrs(

Fomc-Tyrs(tBu)-OH

Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-tert-butyl-L-tyrosine

Fmoc-O-tert-butyl-L-tyrosine≥ 99.7% (HPLC, Chiral purity)

(9-fluorenylmethoxycarbonyl)-O-tert-butyl-L-tyrosine

Fmoc-O-tert-butyl-L-tyrosine, N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-tyrosine

FMOC-L-TYR(TBU)-OH

FMOC-L-TYR(O-T-BUTYL)

FMOC-L-TYR(T-BU)

2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoic acid

N-(9-Fluorenylmethoxycarbonyl)-o-tert-butyl-L-tyrosine ,98%

4-tert-Butoxy-Fmoc-Phe-OH

N-(9H-Fluorene-9-ylmethoxycarbonyl)-O-tert-butyl-L-tyrosine

N-(9H-Fluorene-9-ylmethoxycarbonyl)-O-tert-butyltyrosine

O-(1,1-Dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-tyrosine

O-tert-Butyl-N-(9H-fluorene-9-ylmethoxycarbonyl)-L-tyrosine

O-tert-Butyl-N-(9H-fluorene-9-ylmethoxycarbonyl)tyrosine

Fmoc-(O-terbutyl)Tyrosine

Fmoc-O-tert-butyl-L-

FMco-Tyr(tBu)-OH

L-TYROSINE-N-FMOC, O-TERT-BUTYL ETHER

O-tert-Butyl-Nalpha-Fmoc-L-tyrosine Nalpha-Fmoc-O-tert-butyl-L-tyrosine Fmoc-Tyr(tBu)-OH

N^a-FMoc-O-tert-butyl-L-tyrosine, 98%

Fmoc-Tyr(tBu)-OH >=98.0% (HPLC)

FMOC-TYR(BUT)-OH

FMOC-TYR(BUT)

FMOC-TYROSINE(TBU)-OH

FMOC-TYR(TBU)

FMOC-TYR(TBU)-OH

FMOC-TYR(TRT)-OH