Fmoc-Tyr(tBu)-OH
- Product Name
- Fmoc-Tyr(tBu)-OH
- CAS No.
- 71989-38-3
- Chemical Name
- Fmoc-Tyr(tBu)-OH
- Synonyms
- FMOC-TYR(TBU)-OH;FMOC-TYR(TBU);Fmoc-Tyr(otbu)-OH;Tyr(tBu);FMOC-L-TYR(TBU)-OH;FMOC-TYR(TRT)-OH;FMOC-TYR(BUT);FMOC-L-TYROSINE(O-T-BUTYL);FMOC-L-TYR(TBU)-OH(71989-38-3);(2S)-3-[4-(tert-butoxy)phenyl]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
- CBNumber
- CB5854161
- Molecular Formula
- C28H29NO5
- Formula Weight
- 459.53
- MOL File
- 71989-38-3.mol
Fmoc-Tyr(tBu)-OH Property
- Melting point:
- ~150 °C (dec.)
- alpha
- -28 º (c=1, DMF)
- Boiling point:
- 658.2±55.0 °C(Predicted)
- Density
- 1.218±0.06 g/cm3(Predicted)
- refractive index
- -30 ° (C=1, DMF)
- storage temp.
- Store below +30°C.
- solubility
- Chloroform (Slightly), DMF (Slightly), Methanol (Slightly)
- form
- Powder
- pka
- 2.97±0.10(Predicted)
- color
- White
- optical activity
- [α]20/D 29±2°, c = 1% in DMF
- BRN
- 4216652
- InChIKey
- JAUKCFULLJFBFN-VWLOTQADSA-N
- SMILES
- C(O)(=O)[C@H](CC1=CC=C(OC(C)(C)C)C=C1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
- CAS DataBase Reference
- 71989-38-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8.52020
- Product name
- Fmoc-Tyr(tBu)-OH
- Purity
- Novabiochem?
- Packaging
- 25g
- Price
- $90.1
- Updated
- 2024/03/01
- Product number
- 8.52020
- Product name
- Fmoc-Tyr(tBu)-OH
- Purity
- Novabiochem?
- Packaging
- 100g
- Price
- $326
- Updated
- 2024/03/01
- Product number
- 8.52020
- Product name
- Fmoc-Tyr(tBu)-OH
- Purity
- Novabiochem?
- Packaging
- 250g
- Price
- $687
- Updated
- 2024/03/01
- Product number
- 8.52020
- Product name
- Fmoc-Tyr(tBu)-OH
- Purity
- Novabiochem?
- Packaging
- 1kg
- Price
- $2360
- Updated
- 2024/03/01
- Product number
- 47623
- Product name
- Fmoc-Tyr(tBu)-OH
- Purity
- ≥98.0% (HPLC)
- Packaging
- 10g
- Price
- $65.9
- Updated
- 2024/03/01
Fmoc-Tyr(tBu)-OH Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystalline powder; insoluble in water and petroleum ether, soluble in ethyl acetate, methanol and DMF; mp is 150-151°C; specific optical rotation [α] 20D + 5.2° (0.5-2.0mg/ml, ethyl acetate ), [α]20D-27.6° (0.5-2.0 mg/ml, DMF), [α]20D-6° (0.5-2.0 mg/ml, methanol).
Uses
Fmoc-O-tert-butyl-L-tyrosine belongs to L-tyrosine compounds. Its molecular structure contains a chiral center, so it can exist two enantiomers and has optical activity. Fmoc-Tyr(tBu)-OH is used in peptide synthesis as amino acid protection monomer.
Preparation
To obtain Fmoc-Tyr(tBu)-OH, the following steps are carried out:
Suspend O-tert-butyl-L-tyrosine in a solution of dioxane.
Conduct an acylation reaction with fluorenyl methaneoxycarbonyl azide.
After the reaction, extract the crude product with ethyl acetate under pH 9-10 conditions.
Purify the extracted product through recrystallization.
This process results in the final product, Fmoc-Tyr(tBu)-OH.
General Description
Fmoc-Tyr(tBu)-OH is the preferred tyrosine derivative for solid phase peptide synthesis by Fmoc protocols. Protecting the Tyr sidechain may not be essential in the synthesis of small peptides. If the phenolic functional group of tyrosine does become acylated during a coupling reaction, the subsequent treatment with piperdine to remove Fmoc-groups will also remove any acylation of the phenolic function. Using Fmoc-Tyr(tBu)-OH in peptide synthesis is more efficient, however, since none of the activated amino acids are used unproductively in acylating exposed tyrosine side-chains. The use of Fmoc-Tyr(tBu)-OH also eliminates all potential for side products arising from the acylation of the tyrosine side-chain.
Fmoc-Tyr(tBu)-OH Preparation Products And Raw materials
Raw materials
Preparation Products
Fmoc-Tyr(tBu)-OH Suppliers
- Tel
- 15888978871 15888978871
- 994350525@qq.com
- Country
- China
- ProdList
- 23
- Advantage
- 58
- Tel
- 025-58361106-805 13082558573
- Fax
- 025-58361106-806
- liugang@njpeptide.com
- Country
- China
- ProdList
- 9961
- Advantage
- 55
- Tel
- 021-61263455 13167021076
- amy@glschina.com
- Country
- China
- ProdList
- 8129
- Advantage
- 58
- Tel
- 021-13611955358 13611955358
- yanfen2023@126.com
- Country
- China
- ProdList
- 1313
- Advantage
- 58
- Tel
- 13347833233
- 120300346@qq.com
- Country
- China
- ProdList
- 31
- Advantage
- 58
- Tel
- 028-61682518; 19983060238
- sales@tachem.cn
- Country
- China
- ProdList
- 109
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006608290; 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40241
- Advantage
- 62
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- sales@jonln.com
- Country
- China
- ProdList
- 1998
- Advantage
- 65
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30132
- Advantage
- 84
- Tel
- 0838-2809458 13350585791
- Fax
- +86-838-2274207
- pharm@biots.cn
- Country
- China
- ProdList
- 348
- Advantage
- 66
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24539
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44751
- Advantage
- 61
- Tel
- 21-61263452 13641803416
- Fax
- 86-21-61263399
- ymbetter@glbiochem.com
- Country
- China
- ProdList
- 9981
- Advantage
- 64
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- sales@capotchem.com
- Country
- China
- ProdList
- 18217
- Advantage
- 66
- Tel
- 010-82967028 13552068683
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12458
- Advantage
- 60
- Tel
- +86-21-54098501
- Fax
- +86-21-54096319
- sales@sinch.com.cn
- Country
- China
- ProdList
- 11605
- Advantage
- 64
- Tel
- +86-28-86127071
- Fax
- +86-28-86127072
- info@sino-produce.com
- Country
- China
- ProdList
- 411
- Advantage
- 66
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9551
- Advantage
- 66
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11660
- Advantage
- 64
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9816
- Advantage
- 59
- Tel
- 021-54306202 13764082696;
- info@hanhongsci.com
- Country
- China
- ProdList
- 42982
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 15421
- Advantage
- 60
- Tel
- 0712-0712-2580635 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8849
- Advantage
- 52
- Tel
- 13355009207 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18739
- Advantage
- 57
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12990
- Advantage
- 57
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11726
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14443
- Advantage
- 57
- Tel
- 021-61551611 13296011611
- Fax
- +86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9900
- Advantage
- 58
- Tel
- 028-87925786 18982287581
- Fax
- 028-61777050
- sales@cdforestchem.com
- Country
- China
- ProdList
- 1374
- Advantage
- 58
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9872
- Advantage
- 52
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17779
- Advantage
- 75
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12338
- Advantage
- 58
- Tel
- 025-66099280 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19918
- Advantage
- 55
- Tel
- 021-50430803 18017383231
- Fax
- qq:2817624287
- 983544897@qq.com
- Country
- China
- ProdList
- 9352
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22519
- Advantage
- 55
- Tel
- 18521735133 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25015
- Advantage
- 65
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9552
- Advantage
- 55
- Tel
- 86-0755-86635001
- Fax
- 86-0755-22642228
- cantotech@126.com
- Country
- China
- ProdList
- 4576
- Advantage
- 55
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7876
- Advantage
- 55
- Tel
- 021-61119791,13386096464
- Fax
- 021-50190009
- bzswkf@foxmail.com
- Country
- China
- ProdList
- 3924
- Advantage
- 50
- Tel
- 0512-56316828 4008675858
- Fax
- +86-512-56316826
- sales@amateksci.com
- Country
- China
- ProdList
- 9908
- Advantage
- 55
- Tel
- 023-62879767 13996269627;
- Fax
- +86-28-84559521
- sales@conier.com
- Country
- China
- ProdList
- 294
- Advantage
- 56
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3123
- Advantage
- 55
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- 422131432@qq.com
- Country
- China
- ProdList
- 9986
- Advantage
- 55
- Tel
- 400-1647117 15221909166
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41438
- Advantage
- 60
- Tel
- 1352-6885213 15637198702
- Fax
- 0371-63709726
- xpkchem@163.com
- Country
- China
- ProdList
- 3998
- Advantage
- 58
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 17982
- Advantage
- 56
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7892
- Advantage
- 56
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15185
- Advantage
- 58
View Lastest Price from Fmoc-Tyr(tBu)-OH manufacturers
- Product
- Fmoc-L-Tyr(tBu)-OH 71989-38-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T
- Release date
- 2023-12-11
- Product
- Fmoc-Tyr(tBu)-OH 71989-38-3
- Price
- US $0.00/gram
- Min. Order
- 25gram
- Purity
- 99% HPLC
- Supply Ability
- 25 gram
- Release date
- 2023-10-16
- Product
- Fmoc-O-tert-butyl-L-tyrosine 71989-38-3
- Price
- US $0.00/Kg/Bag
- Min. Order
- 10g
- Purity
- 98%min
- Supply Ability
- 100kgs
- Release date
- 2021-10-15