LGK-974
- Product Name
- LGK-974
- CAS No.
- 1243244-14-5
- Chemical Name
- LGK-974
- Synonyms
- LGK-974;CS-1102;WNT-974;NVP-LGK974;LGK974; LGK-974;LGK974 (WNT974);LGK-974 USP/EP/BP;LGK974(NVP-LGK974);LGK974; LGK 974; NVP-LGK974;7'-Dichlorodihydrofluorescein diacetate
- CBNumber
- CB72655412
- Molecular Formula
- C23H20N6O
- Formula Weight
- 396.44
- MOL File
- 1243244-14-5.mol
LGK-974 Property
- Melting point:
- 176 - 180°C
- Boiling point:
- 650.9±55.0 °C(Predicted)
- Density
- 1.268±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 12.24±0.70(Predicted)
- form
- Solid
- color
- White to Off-White
Safety
- HS Code
- 2933399990
N-Bromosuccinimide Price
- Product number
- 5.31091
- Product name
- Porcn Inhibitor IV, LGK974 - CAS 1243244-14-5 - Calbiochem
- Purity
- A cell-permeable inhibitor of Wnt secretion from L-cell Wnt1/2/3/3a/6/7a/9a transfectants (IC?? from 50 pM to 1.1 nM).
- Packaging
- 5MG
- Price
- $239
- Updated
- 2024/03/01
- Product number
- 14072
- Product name
- LGK974
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 14072
- Product name
- LGK974
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 14072
- Product name
- LGK974
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $195
- Updated
- 2024/03/01
- Product number
- L397640
- Product name
- LGK974
- Packaging
- 500μg
- Price
- $55
- Updated
- 2021/12/16
LGK-974 Chemical Properties,Usage,Production
Description
Porcupine (PORCN) is a membrane bound O-
Uses
LGK 974 is a potent and specific small molecule Porcupine (PORCN) inhibitor.
Definition
ChEBI: LGK974 is a carboxamide, the structure of which is that of acetamide substituted on carbon by a 2',3-dimethyl-2,4'-bipyridin-5-yl group and on nitrogen by a 5-(pyrazin-2-yl)pyridin-2-yl group. It is a highly potent, selective and orally bioavailable Porcupine inhibitor (a Wnt signalling inhibitor). It has a role as a Wnt signalling inhibitor. It is a member of bipyridines, a member of pyrazines, a member of pyridines and a secondary carboxamide. It is functionally related to an acetamide.
target
PORCN
References
[1] liu j, pan s, hsieh mh, ng n, sun f, wang t, kasibhatla s, schuller ag, li ag, cheng d, li j, tompkins c, pferdekamper a, steffy a, cheng j, kowal c, phung v, guo g, wang y, graham mp, flynn s, brenner jc, li c, villarroel mc, schultz pg, wu x, mcnamara p, sellers wr, petruzzelli l, boral al, seidel hm, mclaughlin me, che j, carey te, vanasse g, harris jl. targeting wnt-driven cancer through the inhibition of porcupine by lgk974. proc natl acad sci u s a. 2013 dec 10;110(50):20224-9.
LGK-974 Preparation Products And Raw materials
Raw materials
Preparation Products
LGK-974 Suppliers
- Tel
- 13524779951
- Fax
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- Country
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View Lastest Price from LGK-974 manufacturers
- Product
- LGK-974 1243244-14-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-08-29
- Product
- LGK-974 1243244-14-5
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10