ChemicalBook > CAS DataBase List > LGK-974

LGK-974

Product Name
LGK-974
CAS No.
1243244-14-5
Chemical Name
LGK-974
Synonyms
LGK-974;CS-1102;WNT-974;NVP-LGK974;LGK974; LGK-974;LGK974 (WNT974);LGK-974 USP/EP/BP;LGK974(NVP-LGK974);LGK974; LGK 974; NVP-LGK974;7'-Dichlorodihydrofluorescein diacetate
CBNumber
CB72655412
Molecular Formula
C23H20N6O
Formula Weight
396.44
MOL File
1243244-14-5.mol
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LGK-974 Property

Melting point:
176 - 180°C
Boiling point:
650.9±55.0 °C(Predicted)
Density 
1.268±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
12.24±0.70(Predicted)
form 
Solid
color 
White to Off-White
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.31091
Product name
Porcn Inhibitor IV, LGK974 - CAS 1243244-14-5 - Calbiochem
Purity
A cell-permeable inhibitor of Wnt secretion from L-cell Wnt1/2/3/3a/6/7a/9a transfectants (IC?? from 50 pM to 1.1 nM).
Packaging
5MG
Price
$239
Updated
2024/03/01
Cayman Chemical
Product number
14072
Product name
LGK974
Purity
≥98%
Packaging
500μg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
14072
Product name
LGK974
Purity
≥98%
Packaging
1mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
14072
Product name
LGK974
Purity
≥98%
Packaging
5mg
Price
$195
Updated
2024/03/01
TRC
Product number
L397640
Product name
LGK974
Packaging
500μg
Price
$55
Updated
2021/12/16
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LGK-974 Chemical Properties,Usage,Production

Description

Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. LGK974 is a potent and specific small molecule inhibitor of PORCN (IC50 = 0.4 nM). It greatly reduces Wnt secretion without decreasing its synthesis and without increasing cytotoxicity. LGK974 is orally bioavailable in mice and induces tumor regression in mouse breast tumors produced by mammary tumor virus-driven Wnt1 signaling. It also blocks carcinogenesis in other Wnt-related tumors at doses that have limited impact on stem cell renewal.

Uses

LGK 974 is a potent and specific small molecule Porcupine (PORCN) inhibitor.

Definition

ChEBI: LGK974 is a carboxamide, the structure of which is that of acetamide substituted on carbon by a 2',3-dimethyl-2,4'-bipyridin-5-yl group and on nitrogen by a 5-(pyrazin-2-yl)pyridin-2-yl group. It is a highly potent, selective and orally bioavailable Porcupine inhibitor (a Wnt signalling inhibitor). It has a role as a Wnt signalling inhibitor. It is a member of bipyridines, a member of pyrazines, a member of pyridines and a secondary carboxamide. It is functionally related to an acetamide.

target

PORCN

References

[1] liu j, pan s, hsieh mh, ng n, sun f, wang t, kasibhatla s, schuller ag, li ag, cheng d, li j, tompkins c, pferdekamper a, steffy a, cheng j, kowal c, phung v, guo g, wang y, graham mp, flynn s, brenner jc, li c, villarroel mc, schultz pg, wu x, mcnamara p, sellers wr, petruzzelli l, boral al, seidel hm, mclaughlin me, che j, carey te, vanasse g, harris jl. targeting wnt-driven cancer through the inhibition of porcupine by lgk974. proc natl acad sci u s a. 2013 dec 10;110(50):20224-9.

LGK-974 Preparation Products And Raw materials

Raw materials

Preparation Products

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LGK-974 Suppliers

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View Lastest Price from LGK-974 manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
LGK-974 1243244-14-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-29
Career Henan Chemical Co
Product
LGK-974 1243244-14-5
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-10

1243244-14-5, LGK-974Related Search:

N-Methylaniline Didecyl dimethyl ammonium chloride N,N'-Dimethyl-1,3-propanediamine N,N-Dimethylbenzylamine N,N-Dimethylbenzamide xav-939 Wnt-C59 MG-132 Sunitinib Malate CHIR-99021 Olaparib

  • CS-1102
  • LGK974; LGK-974
  • 2-(2',3-Dimethyl-2,4'-bipyridin-5-yl)-N-[5-(2-pyrazinyl)-2-pyridi nyl]acetamide
  • LGK974(NVP-LGK974)
  • 2-[5-Methyl-6-(2-methyl-4-pyridyl)-3-pyridyl]-N-(5-pyrazin-2-yl-2-pyridyl)acetamide
  • LGK-974
  • 2-(2',3-diMethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetaMide
  • 2',3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide
  • [2,4'-Bipyridine]-5-acetamide, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-
  • NVP-LGK974
  • LGK-974 2',3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide
  • 2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide hydrochloride
  • LGK974; LGK 974; NVP-LGK974
  • WNT-974
  • LGK974 (WNT974)
  • LGK-974 USP/EP/BP
  • 2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide
  • 7'-Dichlorodihydrofluorescein diacetate
  • Acotiamide Impurity LGK（Acotiamide Impurity 43）
  • Acotiamide Impurity LGK or Acotiamide Impurity 43
  • 2 ', 3-dimethyl-N - [5- (2-pyrazinyl) -2-pyridyl] - [2,4' - bipyridine] -5-acetamide
  • 2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide
  • 1243244-14-5
  • 243244-14-5
  • Inhibitors