LGK-974

Product Name: LGK-974
CAS No.: 1243244-14-5
Chemical Name: LGK-974
Synonyms: LGK-974;CS-1102;WNT-974;NVP-LGK974;LGK974; LGK-974;LGK974 (WNT974);LGK-974 USP/EP/BP;LGK974(NVP-LGK974);LGK974; LGK 974; NVP-LGK974;7'-Dichlorodihydrofluorescein diacetate
CBNumber: CB72655412
Molecular Formula: C23H20N6O
Formula Weight: 396.44
MOL File: 1243244-14-5.mol

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LGK-974 Property

Melting point:: 176 - 180°C
Boiling point:: 650.9±55.0 °C(Predicted)
Density: 1.268±0.06 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 12.24±0.70(Predicted)
form: Solid
color: White to Off-White

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.31091
Product name: Porcn Inhibitor IV, LGK974 - CAS 1243244-14-5 - Calbiochem
Purity: A cell-permeable inhibitor of Wnt secretion from L-cell Wnt1/2/3/3a/6/7a/9a transfectants (IC?? from 50 pM to 1.1 nM).
Packaging: 5MG
Price: $239
Updated: 2024/03/01

Cayman Chemical

Product number: 14072
Product name: LGK974
Purity: ≥98%
Packaging: 500μg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 14072
Product name: LGK974
Purity: ≥98%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 14072
Product name: LGK974
Purity: ≥98%
Packaging: 5mg
Price: $195
Updated: 2024/03/01

TRC

Product number: L397640
Product name: LGK974
Packaging: 500μg
Price: $55
Updated: 2021/12/16

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LGK-974 Chemical Properties,Usage,Production

Description

Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. LGK974 is a potent and specific small molecule inhibitor of PORCN (IC₅₀ = 0.4 nM). It greatly reduces Wnt secretion without decreasing its synthesis and without increasing cytotoxicity. LGK974 is orally bioavailable in mice and induces tumor regression in mouse breast tumors produced by mammary tumor virus-driven Wnt1 signaling. It also blocks carcinogenesis in other Wnt-related tumors at doses that have limited impact on stem cell renewal.

Uses

LGK 974 is a potent and specific small molecule Porcupine (PORCN) inhibitor.

Definition

ChEBI: LGK974 is a carboxamide, the structure of which is that of acetamide substituted on carbon by a 2',3-dimethyl-2,4'-bipyridin-5-yl group and on nitrogen by a 5-(pyrazin-2-yl)pyridin-2-yl group. It is a highly potent, selective and orally bioavailable Porcupine inhibitor (a Wnt signalling inhibitor). It has a role as a Wnt signalling inhibitor. It is a member of bipyridines, a member of pyrazines, a member of pyridines and a secondary carboxamide. It is functionally related to an acetamide.

target

PORCN

References

[1] liu j, pan s, hsieh mh, ng n, sun f, wang t, kasibhatla s, schuller ag, li ag, cheng d, li j, tompkins c, pferdekamper a, steffy a, cheng j, kowal c, phung v, guo g, wang y, graham mp, flynn s, brenner jc, li c, villarroel mc, schultz pg, wu x, mcnamara p, sellers wr, petruzzelli l, boral al, seidel hm, mclaughlin me, che j, carey te, vanasse g, harris jl. targeting wnt-driven cancer through the inhibition of porcupine by lgk974. proc natl acad sci u s a. 2013 dec 10;110(50):20224-9.

LGK-974 Preparation Products And Raw materials

Raw materials

Preparation Products

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LGK-974 Suppliers

China 101 India 2 United States 11 Global 114

Shanghai XingMo Biotechnology Co., Ltd.

Tel: 13524779951
Fax: QQ: 2075692521
Email: 2075692521@qq.com
Country: China
ProdList: 310
Advantage: 55

Shanghai Tachizaki Biomedical Research Center

Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Country: China
ProdList: 2565
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Jinan Mingya Medical Technology Co., Ltd.

Tel: 0531-85828981
Fax: +86-531-85806006
Email: 864598798@qq.com
Country: China
ProdList: 588
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

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View Lastest Price from LGK-974 manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: LGK-974 1243244-14-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-29

Career Henan Chemical Co

Product: LGK-974 1243244-14-5
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-10

1243244-14-5, LGK-974Related Search:

N-Methylaniline Didecyl dimethyl ammonium chloride N,N'-Dimethyl-1,3-propanediamine N,N-Dimethylbenzylamine N,N-Dimethylbenzamide xav-939 Wnt-C59 MG-132 Sunitinib Malate CHIR-99021 Olaparib

CS-1102

LGK974; LGK-974

2-(2',3-Dimethyl-2,4'-bipyridin-5-yl)-N-[5-(2-pyrazinyl)-2-pyridi nyl]acetamide

LGK974(NVP-LGK974)

2-[5-Methyl-6-(2-methyl-4-pyridyl)-3-pyridyl]-N-(5-pyrazin-2-yl-2-pyridyl)acetamide

LGK-974

2-(2',3-diMethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetaMide

2',3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide

[2,4'-Bipyridine]-5-acetamide, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-

NVP-LGK974

LGK-974 2',3-Dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-[2,4'-bipyridine]-5-acetamide

2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide hydrochloride

LGK974; LGK 974; NVP-LGK974

WNT-974

LGK974 (WNT974)

LGK-974 USP/EP/BP

2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide

7'-Dichlorodihydrofluorescein diacetate

Acotiamide Impurity LGK（Acotiamide Impurity 43）

Acotiamide Impurity LGK or Acotiamide Impurity 43

2 ', 3-dimethyl-N - [5- (2-pyrazinyl) -2-pyridyl] - [2,4' - bipyridine] -5-acetamide

2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide

1243244-14-5

243244-14-5

Inhibitors