CL 82198 HYDROCHLORIDE
- Product Name
- CL 82198 HYDROCHLORIDE
- CAS No.
- 307002-71-7
- Chemical Name
- CL 82198 HYDROCHLORIDE
- Synonyms
- CL-82198 (CL82198;CL 82198 hydrochlori;CL 82198 HYDROCHLORIDE;N-(4-Morpholinobutyl)benzofuran-2-carboxamide;N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide;2-Benzofurancarboxamide, N-[4-(4-morpholinyl)butyl]-;CL-82198, Matrix metalloprotinase -13 (MMP-13) inhibitor;Benzofuran-2-carboxylic acid (4-morpholin-4-yl-butyl)-amide;N-(4-Morpholinobutyl)benzofuran-2-carboxamide hydrochloride;N-[4-(4-MORPHOLINYL)BUTYL]-2-BENZOFURANCARBOXAMIDE HYDROCHLORIDE
- CBNumber
- CB42450342
- Molecular Formula
- C17H22N2O3
- Formula Weight
- 302.37
- MOL File
- 307002-71-7.mol
CL 82198 HYDROCHLORIDE Property
- Boiling point:
- 515.6±40.0 °C(Predicted)
- Density
- 1.159±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >10mg/mL
- form
- powder
- pka
- 14.19±0.46(Predicted)
- color
- white to off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 6 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C9498
- Product name
- CL-82198
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $90
- Updated
- 2024/03/01
- Product number
- C9498
- Product name
- CL-82198
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $371
- Updated
- 2024/03/01
- Product number
- 16928
- Product name
- CL-82198
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 16928
- Product name
- CL-82198
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 16928
- Product name
- CL-82198
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $270
- Updated
- 2024/03/01
CL 82198 HYDROCHLORIDE Chemical Properties,Usage,Production
Description
CL 82,198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13), producing 89% inhibition at 10 μg/ml. It is without effect against MMP-1, MMP-9 or TNF-α converting enzyme. CL 82,198 is used to evaluate the role of MMP-13 in diverse processes, including cancer cell migration, acute lung injury, and joint degeneration associated with osteoarthritis.
Uses
CL-82198 is a selective inhibitor of human collagenase-3, known as matrix metalloproteinase-13.
Biological Activity
Selective inhibitor of MMP-13 (89% inhibition at 10 μ g/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro invasion by the human pituitary adenoma cell line HP75.
Biochem/physiol Actions
CL-82198 is a selective inhibitor of MMP-13 that displays no activity at MMP-1, MMP-9 or TACE. It is also a selective S1′ pocket binder, binding within the entire S1′ pocket of MMP-13, docking with the morpholine ring adjacent to the catalytic zinc atom without zinc chelation.
in vitro
cl-82198 was identified as a weak inhibitor against mmp-13 and demonstrated no activity against mmp-1, mmp-9, or the related enzyme tace. bearing drug-like properties, cl-82198 was regarded as an ideal candidate for optimization of enzyme potency and selectivity. in nmr binding studies, it was shown that cl-82198 bound within the entire s1’ pocket of mmp-13, which was the basis of its selectivity against mmp-1, mmp-9, and tace [1].
in vivo
to investigate the contribution of mmp-13 down-regulation during gastroprotection by acetaminophen, the effects of cl-82198 on ibp-induced gastric damage were evaluated. results showed that cl-82198 decreased gastric lesions in a dose-dependent manner in the presence of ibp. compared with ibp administration alone, cl-82198 administered at 0.2 and 1.0 mg/kg resulted in 40.3% and 72.1% decrease in gastric lesion, respectively [1].
IC 50
89% inhibition at 10μg/ml
References
1) Chen, et al. (2000), Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design; J. Am. Chem. Soc., 122 9648
CL 82198 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
CL 82198 HYDROCHLORIDE Suppliers
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15839
- Advantage
- 69
- Tel
- 0330-2528181
- Fax
- 0330-2528171
- sales@vdmbio.com
- Country
- United States
- ProdList
- 510
- Advantage
- 64
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
- info@adooq.com
- Country
- United States
- ProdList
- 2782
- Advantage
- 58
- Tel
- 021-24206007 13764915196
- Fax
- 86-021-23027023
- sales@balmxy.com
- Country
- China
- ProdList
- 6773
- Advantage
- 55
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51456
- Advantage
- 80
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 15076683720
- Fax
- 022-23754520
- klq@cw-bio.com
- Country
- China
- ProdList
- 5930
- Advantage
- 55
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8011
- Advantage
- 62
- Tel
- 021-2022843681 15618226720
- Fax
- +86-21-51601218
- lucy@atkchemical.com
- Country
- China
- ProdList
- 9952
- Advantage
- 58