Ilomastat
- Product Name
- Ilomastat
- CAS No.
- 142880-36-2
- Chemical Name
- Ilomastat
- Synonyms
- CS-1405;SANTACRUZ;llomastat;sc-203979A;IlloMastat;galardin tm;Ilomastat, >=98%;GM 6001 Ilomastat;Ilomastat (GM 6001);Galardin CS 610
- CBNumber
- CB11178927
- Molecular Formula
- C20H28N4O4
- Formula Weight
- 388.46
- MOL File
- 142880-36-2.mol
Ilomastat Property
- Density
- 1.228±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO, and 100% ethanol.
- pka
- 9.16±0.20(Predicted)
- form
- Off-white solid
- color
- White
- Sensitive
- Moisture Sensitive
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- InChIKey
- NITYDPDXAAFEIT-DYVFJYSZSA-N
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 364205
- Product name
- GM 6001
- Packaging
- 1mg
- Price
- $113
- Updated
- 2024/03/01
- Product number
- 364205
- Product name
- GM 6001
- Packaging
- 5mg
- Price
- $403
- Updated
- 2024/03/01
- Product number
- J65687
- Product name
- GM 6001
- Packaging
- 5mg
- Price
- $366
- Updated
- 2023/06/20
- Product number
- J65687
- Product name
- GM 6001
- Packaging
- 1mg
- Price
- $81.1
- Updated
- 2021/12/16
- Product number
- 14533
- Product name
- GM 6001
- Purity
- ≥90%
- Packaging
- 500μg
- Price
- $32
- Updated
- 2024/03/01
Ilomastat Chemical Properties,Usage,Production
Description
Ilomastat (142880-36-2) is a potent pan-specific inhibitor of matrix metalloproteinases (MMPs).1 Ki values have been reported for the following human MMPs: MMP-1, 0.4nM; MMP-2, 0.5nM; MMP-3, 27nM; MMP-7, 3.7nM; MMP-8, 0.1nM; MMP-9, 0.2nM; MMP-12, 3.6nM; MMP-14, 13.4nM; MMP-26, 0.36nM.2-4 Also inhibits MMP-10, MMP-13, MMP-15, MMP-17, MMP-20, MMP-21, TACE and ADAM19.
Uses
GM 6001 is a potent, reversible broad spectrum inhibitor of zinc-containing proteases, including matrix metalloproteinases (MMPs). It inhibits zinc-containing thermolysin and elastase from P. aeruginosa, both with Ki values of 20 nM. GM 6001 inhibits MMP-1, -2, -7, -8, -9, -12, -13, -14, -16, and -26 with Ki or IC50 values between 0.1 and 10 nM. It inhibits disintegrin and metalloproteinase domain-containing (ADAM) proteins ADAM9, ADAM10, ADAM12, and ADAM17 at nanomolar concentrations. It less potently inhibits lethal factor from B. anthracis anthrax lethal toxin (Ki = 2.74 μM). GM 6001 also impairs the growth of the human pathogen Chlamydia by inhibiting peptide deformylase, which contains iron rather than zinc (IC50 = 38 nM).
Uses
Ilomastat is a metalloprotease inhibitor.
Definition
ChEBI: Ilomastat is an N-acyl-amino acid obtained by formal condensation of the carboxy group of (2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the amino group of N-methyl-L-tryptophanamide. A cell permeable broad-spectrum matrix metalloproteinase (MMP) inhibitor It has a role as an EC 3.4.24.24 (gelatinase A) inhibitor, a neuroprotective agent, an anti-inflammatory agent, an antibacterial agent and an antineoplastic agent. It is a L-tryptophan derivative, a hydroxamic acid and a N-acyl-amino acid.
General Description
A cell-permeable, potent broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs). [Ki = 0.4 nM for skin fibroblast collagenase (MMP-1); Ki = 0.5 nM for gelatinase A (MMP-2); Ki = 27 nM for stromelysin (MMP-3); Ki = 0.1 nM for neutrophil collagenase (MMP-8); and Ki = 0.2 nM for gelatinase B (MMP-9)]. Also prevents the release of TNF-α in vivo and in vitro and abrogates endotoxin-induced lethality in mice.
Biochem/physiol Actions
GM6001 promotes cardiovascular and hepatocellular function.
storage
Store at -20°C
References
1) Saghatelian et al. (2004) Activity-based probes for the proteomic profiling of metalloproteases; Proc. Natl. Acad. Sci. USA, 101 10000 2) Galardy et al. (1994) Low molecular weight inhibitors in corneal ulceration; Ann. N.Y. Acad..Sci. 732 315 3) Yamamoto et al.(1998) Inhibition of Membrane-Type 1 Matrix Metalloproteinase by Hydroxamate Inhibitors: An Examination of the Subsite Pocket; J. Med. Chem. 41 1209 4) Park et al. (2003) The intermediate S1- pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling; J. Biol. Chem. 278 51646
Ilomastat Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ilomastat manufacturers
- Product
- Ilomastat 142880-36-2
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- G/KG/T
- Release date
- 2019-12-20