AZD-1208

Product Name: AZD-1208
CAS No.: 1204144-28-4
Chemical Name: AZD-1208
Synonyms: CS-794;AZD1208;AZD 1208;AZD-1208;AZD1208 >=95%;AZD 1208;AZD-1208;AZD-1208 USP/EP/BP;AZD1208;AZD 1208;AZD-1208;(R,Z)-5-((2-(3-aminopiperidin-1-yl)biphenyl-3-yl)methylene)thiazolidine-2,4-dione;(R,Z)-5-((2-(3-aMinopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)Methylene)thiazolidine-2,4-dione
CBNumber: CB02666594
Molecular Formula: C21H21N3O2S
Formula Weight: 379.48
MOL File: 1204144-28-4.mol

More

Less

AZD-1208 Property

Melting point:: >220°C (dec.)
Density: 1.307±0.06 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly)
pka: 7.39±0.20(Predicted)
form: Solid
color: Off-White to Pale Yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 20235
Product name: AZD 1208
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 20235
Product name: AZD 1208
Purity: ≥98%
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 20235
Product name: AZD 1208
Purity: ≥98%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 20235
Product name: AZD 1208
Purity: ≥98%
Packaging: 25mg
Price: $230
Updated: 2024/03/01

Tocris

Product number: 6310
Product name: AZD1208
Purity: ≥98%(HPLC)
Packaging: 50
Price: $386
Updated: 2021/12/16

More

Less

AZD-1208 Chemical Properties,Usage,Production

Uses

AZD1208 is a potent, and orally available Pim kinase inhibitor.

Biological Activity

upregulation of pim kinases has been observed in several types of leukemias and lymphomas. pim-1, -2, and -3 promote cell proliferation and survival downstream of cytokine and growth factor signaling pathways. azd1208 is a potent, highly selective, and orally available pim kinase inhibitor.

in vitro

azd1208 inhibited the growth of 5 of 14 acute myeloid leukemia (aml) cell lines tested. in molm-16 cells, azd1208 also causes cell cycle arrest and apoptosis, accompanied by a dose-dependent reduction in phosphorylation of bcl-2 antagonist of cell death [1].

in vivo

azd1208 inhibits the growth of kg-1a and molm-16 xenograft tumors in vivo with a clear pk/pd relationship. treatment with 10 mg/kg or 30 mg/kg of azd1208 led to an 89% tumor growth inhibition or slight regression, respectively [1].

target

Pim1

IC 50

0.4 nm for pim-1, 5.0 nm for pim-2, and 1.9 nm for pim-3

storage

Store at -20°C

References

[1] keeton ek, mceachern k, dillman ks, palakurthi s, cao y, grondine mr, kaur s, wang s, chen y, wu a, shen m, gibbons fd, lamb ml, zheng x, stone rm, deangelo dj, platanias lc, dakin la, chen h, lyne pd, huszar d. azd1208, a potent and selective pan-pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. blood. 2014;123(6):905-13.

AZD-1208 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

AZD-1208 Suppliers

China 106 India 2 United Kingdom 2 United States 16 Global 126

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 17702719238
Email: sales@sun-shinechem.com
Country: China
ProdList: 985
Advantage: 64

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4420
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4727
Advantage: 58

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

More

Less

View Lastest Price from AZD-1208 manufacturers

Career Henan Chemical Co

Product: AZD 1208;AZD1208;AZD-1208;(5Z)-5-[[2-[(3R)-3-aMino-1-piperidinyl][1,1'-biphenyl]-3-yl]Methylene]-2,4-thiazolidinedione 1204144-28-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Release date: 2019-08-31

1204144-28-4, AZD-1208Related Search:

BLU 9931 ZLN005 Esomeprazole magnesium Tariquidar Palbociclib IXABEPILONE PF-04929113 4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide L-4-THIAZOLYLALANINE Ilomastat Crenolanib Doxorubicin hydrochloride Y27632 (hydrochloride) Selumetinib Sunitinib Malate Ibrutinib Afatinib Olaparib

AZD 1208

AZD1208

AZD-1208

(5Z)-5-[[2-[(3R)-3-aMino-1-piperidinyl][1,1'-biphenyl]-3-yl]Methylene]-2,4-thiazolidinedione

(5Z)-5-[[2-[(3R)-3-Amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione AZD1208

(R,Z)-5-((2-(3-aminopiperidin-1-yl)biphenyl-3-yl)methylene)thiazolidine-2,4-dione

(R,Z)-5-((2-(3-aMinopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)Methylene)thiazolidine-2,4-dione

CS-794

AZD1208 >=95%

(5Z)-5-[[2-[(3R)-3-aminopiperidin-1-yl]-3-phenylphenyl]methylidene]-1,3-thiazolidine-2,4-dione

AZD1208;AZD 1208;AZD-1208

AZD 1208;AZD-1208

2,4-Thiazolidinedione, 5-[[2-[(3R)-3-amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-, (5Z)-

AZD-1208 USP/EP/BP

(R,Z)-5-((2-(3-Aminopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)methylene)thiazolidine-2,4-dione

1204144-28-4

Inhibitors

JAK

STAT

JAK/STAT