AZD-1208
- Product Name
- AZD-1208
- CAS No.
- 1204144-28-4
- Chemical Name
- AZD-1208
- Synonyms
- CS-794;AZD1208;AZD 1208;AZD-1208;AZD1208 >=95%;AZD 1208;AZD-1208;AZD-1208 USP/EP/BP;AZD1208;AZD 1208;AZD-1208;(R,Z)-5-((2-(3-aminopiperidin-1-yl)biphenyl-3-yl)methylene)thiazolidine-2,4-dione;(R,Z)-5-((2-(3-aMinopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)Methylene)thiazolidine-2,4-dione
- CBNumber
- CB02666594
- Molecular Formula
- C21H21N3O2S
- Formula Weight
- 379.48
- MOL File
- 1204144-28-4.mol
AZD-1208 Property
- Melting point:
- >220°C (dec.)
- Density
- 1.307±0.06 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly)
- pka
- 7.39±0.20(Predicted)
- form
- Solid
- color
- Off-White to Pale Yellow
N-Bromosuccinimide Price
- Product number
- 20235
- Product name
- AZD 1208
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20235
- Product name
- AZD 1208
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- 20235
- Product name
- AZD 1208
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 20235
- Product name
- AZD 1208
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 6310
- Product name
- AZD1208
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $386
- Updated
- 2021/12/16
AZD-1208 Chemical Properties,Usage,Production
Uses
AZD1208 is a potent, and orally available Pim kinase inhibitor.
Biological Activity
upregulation of pim kinases has been observed in several types of leukemias and lymphomas. pim-1, -2, and -3 promote cell proliferation and survival downstream of cytokine and growth factor signaling pathways. azd1208 is a potent, highly selective, and orally available pim kinase inhibitor.
in vitro
azd1208 inhibited the growth of 5 of 14 acute myeloid leukemia (aml) cell lines tested. in molm-16 cells, azd1208 also causes cell cycle arrest and apoptosis, accompanied by a dose-dependent reduction in phosphorylation of bcl-2 antagonist of cell death [1].
in vivo
azd1208 inhibits the growth of kg-1a and molm-16 xenograft tumors in vivo with a clear pk/pd relationship. treatment with 10 mg/kg or 30 mg/kg of azd1208 led to an 89% tumor growth inhibition or slight regression, respectively [1].
target
Pim1
IC 50
0.4 nm for pim-1, 5.0 nm for pim-2, and 1.9 nm for pim-3
storage
Store at -20°C
References
[1] keeton ek, mceachern k, dillman ks, palakurthi s, cao y, grondine mr, kaur s, wang s, chen y, wu a, shen m, gibbons fd, lamb ml, zheng x, stone rm, deangelo dj, platanias lc, dakin la, chen h, lyne pd, huszar d. azd1208, a potent and selective pan-pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. blood. 2014;123(6):905-13.
AZD-1208 Preparation Products And Raw materials
Raw materials
Preparation Products
AZD-1208 Suppliers
View Lastest Price from AZD-1208 manufacturers
- Product
- AZD 1208;AZD1208;AZD-1208;(5Z)-5-[[2-[(3R)-3-aMino-1-piperidinyl][1,1'-biphenyl]-3-yl]Methylene]-2,4-thiazolidinedione 1204144-28-4
- Price
- US $1.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1lg; 2kg; 5kg; 10kg; 100kg
- Release date
- 2019-08-31