ChemicalBook > CAS DataBase List > AZD-1208

AZD-1208

Product Name
AZD-1208
CAS No.
1204144-28-4
Chemical Name
AZD-1208
Synonyms
CS-794;AZD1208;AZD 1208;AZD-1208;AZD1208 >=95%;AZD 1208;AZD-1208;AZD-1208 USP/EP/BP;AZD1208;AZD 1208;AZD-1208;(R,Z)-5-((2-(3-aminopiperidin-1-yl)biphenyl-3-yl)methylene)thiazolidine-2,4-dione;(R,Z)-5-((2-(3-aMinopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)Methylene)thiazolidine-2,4-dione
CBNumber
CB02666594
Molecular Formula
C21H21N3O2S
Formula Weight
379.48
MOL File
1204144-28-4.mol
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AZD-1208 Property

Melting point:
>220°C (dec.)
Density 
1.307±0.06 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly)
pka
7.39±0.20(Predicted)
form 
Solid
color 
Off-White to Pale Yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20235
Product name
AZD 1208
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
20235
Product name
AZD 1208
Purity
≥98%
Packaging
5mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
20235
Product name
AZD 1208
Purity
≥98%
Packaging
10mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
20235
Product name
AZD 1208
Purity
≥98%
Packaging
25mg
Price
$230
Updated
2024/03/01
Tocris
Product number
6310
Product name
AZD1208
Purity
≥98%(HPLC)
Packaging
50
Price
$386
Updated
2021/12/16
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AZD-1208 Chemical Properties,Usage,Production

Uses

AZD1208 is a potent, and orally available Pim kinase inhibitor.

Biological Activity

upregulation of pim kinases has been observed in several types of leukemias and lymphomas. pim-1, -2, and -3 promote cell proliferation and survival downstream of cytokine and growth factor signaling pathways. azd1208 is a potent, highly selective, and orally available pim kinase inhibitor.

in vitro

azd1208 inhibited the growth of 5 of 14 acute myeloid leukemia (aml) cell lines tested. in molm-16 cells, azd1208 also causes cell cycle arrest and apoptosis, accompanied by a dose-dependent reduction in phosphorylation of bcl-2 antagonist of cell death [1].

in vivo

azd1208 inhibits the growth of kg-1a and molm-16 xenograft tumors in vivo with a clear pk/pd relationship. treatment with 10 mg/kg or 30 mg/kg of azd1208 led to an 89% tumor growth inhibition or slight regression, respectively [1].

target

Pim1

IC 50

0.4 nm for pim-1, 5.0 nm for pim-2, and 1.9 nm for pim-3

storage

Store at -20°C

References

[1] keeton ek, mceachern k, dillman ks, palakurthi s, cao y, grondine mr, kaur s, wang s, chen y, wu a, shen m, gibbons fd, lamb ml, zheng x, stone rm, deangelo dj, platanias lc, dakin la, chen h, lyne pd, huszar d. azd1208, a potent and selective pan-pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. blood. 2014;123(6):905-13.

AZD-1208 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD-1208 Suppliers

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WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
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View Lastest Price from AZD-1208 manufacturers

Career Henan Chemical Co
Product
AZD 1208;AZD1208;AZD-1208;(5Z)-5-[[2-[(3R)-3-aMino-1-piperidinyl][1,1'-biphenyl]-3-yl]Methylene]-2,4-thiazolidinedione 1204144-28-4
Price
US $1.00-1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1lg; 2kg; 5kg; 10kg; 100kg
Release date
2019-08-31

1204144-28-4, AZD-1208Related Search:

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  • AZD 1208
  • AZD1208
  • AZD-1208
  • (5Z)-5-[[2-[(3R)-3-aMino-1-piperidinyl][1,1'-biphenyl]-3-yl]Methylene]-2,4-thiazolidinedione
  • (5Z)-5-[[2-[(3R)-3-Amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione AZD1208
  • (R,Z)-5-((2-(3-aminopiperidin-1-yl)biphenyl-3-yl)methylene)thiazolidine-2,4-dione
  • (R,Z)-5-((2-(3-aMinopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)Methylene)thiazolidine-2,4-dione
  • CS-794
  • AZD1208 >=95%
  • (5Z)-5-[[2-[(3R)-3-aminopiperidin-1-yl]-3-phenylphenyl]methylidene]-1,3-thiazolidine-2,4-dione
  • AZD1208;AZD 1208;AZD-1208
  • AZD 1208;AZD-1208
  • 2,4-Thiazolidinedione, 5-[[2-[(3R)-3-amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-, (5Z)-
  • AZD-1208 USP/EP/BP
  • (R,Z)-5-((2-(3-Aminopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)methylene)thiazolidine-2,4-dione
  • 1204144-28-4
  • Inhibitors
  • JAK
  • STAT
  • JAK/STAT