AZD-1208

ChemicalBook > CAS DataBase List > AZD-1208

Product Name: AZD-1208
CAS No.: 1204144-28-4
Chemical Name: AZD-1208
Synonyms: CS-794;AZD1208;AZD 1208;AZD-1208;AZD1208 >=95%;AZD 1208;AZD-1208;AZD-1208 USP/EP/BP;AZD1208;AZD 1208;AZD-1208;(R,Z)-5-((2-(3-aminopiperidin-1-yl)biphenyl-3-yl)methylene)thiazolidine-2,4-dione;(R,Z)-5-((2-(3-aMinopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)Methylene)thiazolidine-2,4-dione
CBNumber: CB02666594
Molecular Formula: C21H21N3O2S
Formula Weight: 379.48
MOL File: 1204144-28-4.mol

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AZD-1208 Property

Melting point:: >220°C (dec.)
Density: 1.307±0.06 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly)
pka: 7.39±0.20(Predicted)
form: Solid
color: Off-White to Pale Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20235
Product name: AZD 1208
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 20235
Product name: AZD 1208
Purity: ≥98%
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 20235
Product name: AZD 1208
Purity: ≥98%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 20235
Product name: AZD 1208
Purity: ≥98%
Packaging: 25mg
Price: $230
Updated: 2024/03/01

Tocris

Product number: 6310
Product name: AZD1208
Purity: ≥98%(HPLC)
Packaging: 10
Price: $92
Updated: 2021/12/16

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AZD-1208 Chemical Properties,Usage,Production

Uses

AZD1208 is a potent, and orally available Pim kinase inhibitor.

Biological Activity

upregulation of pim kinases has been observed in several types of leukemias and lymphomas. pim-1, -2, and -3 promote cell proliferation and survival downstream of cytokine and growth factor signaling pathways. azd1208 is a potent, highly selective, and orally available pim kinase inhibitor.

in vitro

azd1208 inhibited the growth of 5 of 14 acute myeloid leukemia (aml) cell lines tested. in molm-16 cells, azd1208 also causes cell cycle arrest and apoptosis, accompanied by a dose-dependent reduction in phosphorylation of bcl-2 antagonist of cell death [1].

in vivo

azd1208 inhibits the growth of kg-1a and molm-16 xenograft tumors in vivo with a clear pk/pd relationship. treatment with 10 mg/kg or 30 mg/kg of azd1208 led to an 89% tumor growth inhibition or slight regression, respectively [1].

target

Pim1

IC 50

0.4 nm for pim-1, 5.0 nm for pim-2, and 1.9 nm for pim-3

storage

Store at -20°C

References

[1] keeton ek, mceachern k, dillman ks, palakurthi s, cao y, grondine mr, kaur s, wang s, chen y, wu a, shen m, gibbons fd, lamb ml, zheng x, stone rm, deangelo dj, platanias lc, dakin la, chen h, lyne pd, huszar d. azd1208, a potent and selective pan-pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. blood. 2014;123(6):905-13.

AZD-1208 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AZD-1208 manufacturers

Career Henan Chemical Co

Product: AZD 1208;AZD1208;AZD-1208;(5Z)-5-[[2-[(3R)-3-aMino-1-piperidinyl][1,1'-biphenyl]-3-yl]Methylene]-2,4-thiazolidinedione 1204144-28-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Release date: 2019-08-31

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AZD 1208

AZD1208

AZD-1208

(5Z)-5-[[2-[(3R)-3-aMino-1-piperidinyl][1,1'-biphenyl]-3-yl]Methylene]-2,4-thiazolidinedione

(5Z)-5-[[2-[(3R)-3-Amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione AZD1208

(R,Z)-5-((2-(3-aminopiperidin-1-yl)biphenyl-3-yl)methylene)thiazolidine-2,4-dione

(R,Z)-5-((2-(3-aMinopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)Methylene)thiazolidine-2,4-dione

CS-794

AZD1208 >=95%

(5Z)-5-[[2-[(3R)-3-aminopiperidin-1-yl]-3-phenylphenyl]methylidene]-1,3-thiazolidine-2,4-dione

AZD1208;AZD 1208;AZD-1208

AZD 1208;AZD-1208

2,4-Thiazolidinedione, 5-[[2-[(3R)-3-amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-, (5Z)-

AZD-1208 USP/EP/BP

(R,Z)-5-((2-(3-Aminopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)methylene)thiazolidine-2,4-dione

1204144-28-4

Inhibitors

JAK

STAT

JAK/STAT