Flavopiridol
- Product Name
- Flavopiridol
- CAS No.
- 146426-40-6
- Chemical Name
- Flavopiridol
- Synonyms
- Alvocidib;CS-180;C077990;L86-8275;L-868275;L 868275;Hmr 1275;Flavopirodol;FLAVOPIRIDOL;HMR-1275; L86-8275
- CBNumber
- CB7362013
- Molecular Formula
- C21H20ClNO5
- Formula Weight
- 401.84
- MOL File
- 146426-40-6.mol
Flavopiridol Property
- Melting point:
- 52.5 °C
- Boiling point:
- 603.6±55.0 °C(Predicted)
- Density
- 1.448±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- insoluble in H2O; ≥40.2 mg/mL in DMSO; ≥85.4 mg/mL in EtOH with gentle warming and ultrasonic
- form
- Yellow powder.
- pka
- 6.16±0.40(Predicted)
- InChIKey
- BIIVYFLTOXDAOV-YVEFUNNKSA-N
- SMILES
- C1(C2=CC=CC=C2Cl)OC2=C([C@H]3CCN(C)C[C@H]3O)C(O)=CC(O)=C2C(=O)C=1
- CAS DataBase Reference
- 146426-40-6(CAS DataBase Reference)
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 26024
- Product name
- Flavopiridol
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 26024
- Product name
- Flavopiridol
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $208
- Updated
- 2024/03/01
- Product number
- 26024
- Product name
- Flavopiridol
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $384
- Updated
- 2024/03/01
- Product number
- 26024
- Product name
- Flavopiridol
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $656
- Updated
- 2024/03/01
- Product number
- orb154639
- Product name
- Flavopiridol
- Purity
- >99%
- Packaging
- 100mg
- Price
- $690.2
- Updated
- 2021/12/16
Flavopiridol Chemical Properties,Usage,Production
Uses
Antineoplastic (cyclin-dependent kinase inhibitor)[Note—The trivial name, flavopiridol, has appeared in literature].
Uses
Flavopiridol is a synthetic flavonoid derivative, potent inhibitor of CDKs. Inhibitor of CDK9 as a postexposure drug target for adenoviruses.
Definition
ChEBI: Alvocidib is a synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. It has a role as an antineoplastic agent, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an antirheumatic drug and an apoptosis inducer. It is a dihydroxyflavone, a hydroxypiperidine, a member of monochlorobenzenes and a tertiary amino compound. It is a conjugate base of an alvocidib(1+).
Anticancer Research
It is a synthetic derivative of rohitukine plant alkaloid which is obtained fromDysoxylum binectariferum, which is active against leukemia, lymphomas and solidtumors (Shoeb 2006).
Flavopiridol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Flavopiridol manufacturers
- Product
- Flavopiridol 146426-40-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26
- Product
- Flavopiridol 146426-40-6
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-09