Flavopiridol

Product Name: Flavopiridol
CAS No.: 146426-40-6
Chemical Name: Flavopiridol
Synonyms: Alvocidib;CS-180;C077990;L86-8275;L-868275;L 868275;Hmr 1275;Flavopirodol;FLAVOPIRIDOL;HMR-1275; L86-8275
CBNumber: CB7362013
Molecular Formula: C21H20ClNO5
Formula Weight: 401.84
MOL File: 146426-40-6.mol

More

Less

Flavopiridol Property

Melting point:: 52.5 °C
Boiling point:: 603.6±55.0 °C(Predicted)
Density: 1.448±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: insoluble in H2O; ≥40.2 mg/mL in DMSO; ≥85.4 mg/mL in EtOH with gentle warming and ultrasonic
form: Yellow powder.
pka: 6.16±0.40(Predicted)
color: Light yellow to yellow
InChIKey: BIIVYFLTOXDAOV-YVEFUNNKSA-N
SMILES: C1(C2=CC=CC=C2Cl)OC2=C([C@H]3CCN(C)C[C@H]3O)C(O)=CC(O)=C2C(=O)C=1
CAS DataBase Reference: 146426-40-6(CAS DataBase Reference)

More

Less

Safety

HS Code: 2934999090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 26024
Product name: Flavopiridol
Purity: ≥95%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 26024
Product name: Flavopiridol
Purity: ≥95%
Packaging: 25mg
Price: $208
Updated: 2024/03/01

Cayman Chemical

Product number: 26024
Product name: Flavopiridol
Purity: ≥95%
Packaging: 50mg
Price: $384
Updated: 2024/03/01

Cayman Chemical

Product number: 26024
Product name: Flavopiridol
Purity: ≥95%
Packaging: 100mg
Price: $656
Updated: 2024/03/01

Biorbyt Ltd

Product number: orb154639
Product name: Flavopiridol
Purity: >99%
Packaging: 100mg
Price: $690.2
Updated: 2021/12/16

More

Less

Flavopiridol Chemical Properties,Usage,Production

Uses

Antineoplastic (cyclin-dependent kinase inhibitor)[Note—The trivial name, flavopiridol, has appeared in literature].

Uses

Flavopiridol is a synthetic flavonoid derivative, potent inhibitor of CDKs. Inhibitor of CDK9 as a postexposure drug target for adenoviruses.

Definition

ChEBI: Alvocidib is a synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. It has a role as an antineoplastic agent, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an antirheumatic drug and an apoptosis inducer. It is a dihydroxyflavone, a hydroxypiperidine, a member of monochlorobenzenes and a tertiary amino compound. It is a conjugate base of an alvocidib(1+).

Anticancer Research

It is a synthetic derivative of rohitukine plant alkaloid which is obtained fromDysoxylum binectariferum, which is active against leukemia, lymphomas and solidtumors (Shoeb 2006).

Flavopiridol Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Flavopiridol Suppliers

China 178 Europe 1 Germany 2 United Kingdom 5 United States 30 Global 216

Zhengzhou Converging Chemical Co. LTD

Tel: 0371-0371-53399770 18037166334
Email: 2853031800@qq.com
Country: China
ProdList: 3265
Advantage: 58

Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd

Tel: 024-024-88590548 18341751992
Email: 757984502@qq.com
Country: China
ProdList: 891
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 17702719238
Email: sales@sun-shinechem.com
Country: China
ProdList: 985
Advantage: 64

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19179
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

More

Less

View Lastest Price from Flavopiridol manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Flavopiridol 146426-40-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

Career Henan Chemical Co

Product: Flavopiridol 146426-40-6
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-09

146426-40-6, FlavopiridolRelated Search:

CHLOROPHOSPHONAZO III Methyl salicylate METSULFURON METHYL Kresoxim-methyl Solvent Red 43 Thiophanate-methyl Tetrahydro-4H-pyran-4-one Tribenuron methyl Centchroman Haloperidol Methyl Flavopiridol (Alvocidib) HCl (R)-3-Hydroxypiperidine hydrocloride Methyl bromide 4H-PYRAN-4-ONE 4-PIPERIDIN-4-YLPHENOL 2'-HYDROXY-5'-ISOPROPYLACETOPHENONE 4-(3-METHYLPHENYL)PIPERIDINE

FLAVOPIRIDOL

2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3s,4r)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-

Alvocidib

(-)cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one

C077990

Hmr 1275

L 868275

L-868275

L86-8275

Flavopirodol

Flavopiridol(Alvocidib)

vopiridol(Alvocidib)

2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-Methylpiperidin-4-yl]-4H-chroMen-4-one

FLAVOPIRIDOL; HMR-1275;L868275

Alvocidib, Free Base

Flavopiridol 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one

Alvocidib(Flavopiridd)

Flavopiridol, >=99%

CS-180

Flavopiridol (HMR-1275, Alvocidib, L868275)

HMR-1275; L86-8275

FLAVOPIRIDOL (ALVOCIDIB; L868275; HMR-1275)

L868275|||Alvocidib|||NSC 649890 HCl|||HMR-1275

Donepezil Impurity 63

146426-40-6

C21H20ClNO5

API intermediates

APIS