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Flavopiridol

Product Name
Flavopiridol
CAS No.
146426-40-6
Chemical Name
Flavopiridol
Synonyms
Alvocidib;CS-180;C077990;L86-8275;L-868275;L 868275;Hmr 1275;Flavopirodol;FLAVOPIRIDOL;HMR-1275; L86-8275
CBNumber
CB7362013
Molecular Formula
C21H20ClNO5
Formula Weight
401.84
MOL File
146426-40-6.mol
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Flavopiridol Property

Melting point:
52.5 °C
Boiling point:
603.6±55.0 °C(Predicted)
Density 
1.448±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
insoluble in H2O; ≥40.2 mg/mL in DMSO; ≥85.4 mg/mL in EtOH with gentle warming and ultrasonic
form 
Yellow powder.
pka
6.16±0.40(Predicted)
color 
Light yellow to yellow
InChIKey
BIIVYFLTOXDAOV-YVEFUNNKSA-N
SMILES
C1(C2=CC=CC=C2Cl)OC2=C([C@H]3CCN(C)C[C@H]3O)C(O)=CC(O)=C2C(=O)C=1
CAS DataBase Reference
146426-40-6(CAS DataBase Reference)
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26024
Product name
Flavopiridol
Purity
≥95%
Packaging
5mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
26024
Product name
Flavopiridol
Purity
≥95%
Packaging
25mg
Price
$208
Updated
2024/03/01
Cayman Chemical
Product number
26024
Product name
Flavopiridol
Purity
≥95%
Packaging
50mg
Price
$384
Updated
2024/03/01
Cayman Chemical
Product number
26024
Product name
Flavopiridol
Purity
≥95%
Packaging
100mg
Price
$656
Updated
2024/03/01
Biorbyt Ltd
Product number
orb154639
Product name
Flavopiridol
Purity
>99%
Packaging
100mg
Price
$690.2
Updated
2021/12/16
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Flavopiridol Chemical Properties,Usage,Production

Uses

Antineoplastic (cyclin-dependent kinase inhibitor)[Note—The trivial name, flavopiridol, has appeared in literature].

Uses

Flavopiridol is a synthetic flavonoid derivative, potent inhibitor of CDKs. Inhibitor of CDK9 as a postexposure drug target for adenoviruses.

Definition

ChEBI: Alvocidib is a synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. It has a role as an antineoplastic agent, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an antirheumatic drug and an apoptosis inducer. It is a dihydroxyflavone, a hydroxypiperidine, a member of monochlorobenzenes and a tertiary amino compound. It is a conjugate base of an alvocidib(1+).

Anticancer Research

It is a synthetic derivative of rohitukine plant alkaloid which is obtained fromDysoxylum binectariferum, which is active against leukemia, lymphomas and solidtumors (Shoeb 2006).

IC 50

CDK1/Cyc B1: 30 nM (IC50); CDK2/Cyc E: 170 nM (IC50); CDK4/Cyc D1: 100 nM (IC50); MAP: 19000 nM (IC50); PKC: 14000 nM (IC50); EGFR: 22000 nM (IC50)

Flavopiridol Preparation Products And Raw materials

Raw materials

Preparation Products

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Flavopiridol Suppliers

China 206 Europe 1 Germany 2 United Kingdom 5 United States 31 Global 245
kemikalieimport
Tel
--
Fax
--
Email
Sales@kemikalieimport.dk
Country
Europe
ProdList
6685
Advantage
47
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View Lastest Price from Flavopiridol manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Flavopiridol 146426-40-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26
Career Henan Chemical Co
Product
Flavopiridol 146426-40-6
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2020-01-09

146426-40-6, FlavopiridolRelated Search:

CHLOROPHOSPHONAZO III Methyl salicylate METSULFURON METHYL Kresoxim-methyl Solvent Red 43 Tribenuron methyl Tetrahydro-4H-pyran-4-one Centchroman Haloperidol Thiophanate-methyl Methyl Flavopiridol (Alvocidib) HCl (R)-3-Hydroxypiperidine hydrocloride Methyl bromide 4H-PYRAN-4-ONE 4-PIPERIDIN-4-YLPHENOL 2'-HYDROXY-5'-ISOPROPYLACETOPHENONE 4-(3-METHYLPHENYL)PIPERIDINE

  • FLAVOPIRIDOL
  • 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3s,4r)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one
  • 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-
  • Alvocidib
  • (-)cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one
  • C077990
  • Hmr 1275
  • L 868275
  • L-868275
  • L86-8275
  • Flavopirodol
  • Flavopiridol(Alvocidib)
  • vopiridol(Alvocidib)
  • 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-Methylpiperidin-4-yl]-4H-chroMen-4-one
  • FLAVOPIRIDOL; HMR-1275;L868275
  • Alvocidib, Free Base
  • Flavopiridol 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one
  • Alvocidib(Flavopiridd)
  • Flavopiridol, >=99%
  • CS-180
  • Flavopiridol (HMR-1275, Alvocidib, L868275)
  • HMR-1275; L86-8275
  • FLAVOPIRIDOL (ALVOCIDIB; L868275; HMR-1275)
  • L868275|||Alvocidib|||NSC 649890 HCl|||HMR-1275
  • Donepezil Impurity 63
  • Flavopiridol, 10 mM in DMSO
  • 146426-40-6
  • C21H20ClNO5
  • API intermediates
  • APIS