ChemicalBook > CAS DataBase List > FLAVOPIRIDOL HYDROCHLORIDE

FLAVOPIRIDOL HYDROCHLORIDE

Product Name
FLAVOPIRIDOL HYDROCHLORIDE
CAS No.
131740-09-5
Chemical Name
FLAVOPIRIDOL HYDROCHLORIDE
Synonyms
HL 275;CS-976;L-86-8276;NSC 649890;MDL 107826A;Alvocidib HCL;NSC 649890 HCl;Flavopiridol HC;FLAVOPIRIDOL HCL;Flavopiridol HCI
CBNumber
CB1972179
Molecular Formula
C21H21Cl2NO5
Formula Weight
438.3
MOL File
131740-09-5.mol
More
Less

FLAVOPIRIDOL HYDROCHLORIDE Property

Melting point:
169.5-170°C
alpha 
24D -1.73 to -3.9°
storage temp. 
2-8°C
solubility 
H2O: ~2mg/mL
form 
powder
pka
5.68 ± 0.06(at 25℃)
color 
white to light brown
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month
CAS DataBase Reference
131740-09-5
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
RTECS 
DJ2978830
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F3055
Product name
Flavopiridol hydrochloride hydrate
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$156
Updated
2024/03/01
Sigma-Aldrich
Product number
F3055
Product name
Flavopiridol hydrochloride hydrate
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$586
Updated
2024/03/01
Cayman Chemical
Product number
10009197
Product name
Flavopiridol (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
10009197
Product name
Flavopiridol (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
10009197
Product name
Flavopiridol (hydrochloride)
Purity
≥95%
Packaging
25mg
Price
$143
Updated
2024/03/01
More
Less

FLAVOPIRIDOL HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Flavopiridol is an orally bioavailable inhibitor of cyclin dependent kinases (IC50s = ~100, ~100, ~100, and 300 nM for Cdk1, Cdk2, Cdk4, and Cdk7, respectively). It also inhibits TEFb, a complex composed of Cdk9 and cyclin T1, with a Ki value of 3 nM. Flavopiridol inhibits transcription of a CMV promoter in HeLa nuclear extract (IC50 = 34 nM), Tat-stimulated transcription of an HIV-1 promotor (IC50 = 7 nM), and HIV-1 replication in HEK239T cells (IC50 = <10 nM). In vivo, flavopiridol (5 mg/kg, i.p.) induces apoptosis and cyclin D1 depletion and delays tumor growth in an HN-12 head and neck carcinoma mouse xenograft model. It also suppresses synovial hyperplasia and joint destruction in a mouse model of collagen-induced arthritis.

Chemical Properties

Yellow Powder

Uses

An inhibitor of cyclin-dependent kinases; the (-)-cis form induces apoptosis in certain tumor cells.

Uses

Flavopiridol hydrochloride hydrate has been used:

  • as a cyclin-dependent kinase 9 (CDK9) inhibitor to study its effects on histone H3 methylation at lysine 36 (H3K36) and deactivation of transcription in porcine fetal fibroblasts
  • as an RNA polymerase inhibitor to study its effects on hepatic cells
  • as RNA transcription inhibitor to study its effects on euchromatin coarsening in zebrafish embryo

Definition

ChEBI: A hydrochloride salt resulting from the formal reaction of equimolar amounts of alvocidib and hydrogen chloride. A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic p aque formation.

Biochem/physiol Actions

Flavopiridol?is a semi-synthetic flavone obtained from Dysoxylum binectariferum that acts as an anti-tumor agent against several cancers. It also shows anti-cancer properties due to which it has been studied in the treatment of acute myeloid leukemia (AML).

storage

Store at +4°C

References

1) Kaur?et al. (1992),?Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275;? J. Natl. Cancer Inst.,?84?1736 2) Cartee?et al. (2002),?Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways;? Mol. Pharmacol.,?61?1313 3) Ambrosini?et al. (2008),?The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner;? Cancer Res.?68?2312 4) Schang?et al. (2004),?Effects of pharmacological cyclin-dependent kinase inhibitors on viral transcription and replication;? Biochim. Biophys. Acta,?1697?197

FLAVOPIRIDOL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

FLAVOPIRIDOL HYDROCHLORIDE Suppliers

Canada 1 China 117 China Hong Kong 1 India 2 Switzerland 1 United Kingdom 3 United States 22 Global 147
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6011
Advantage
61
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4647
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1494
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
More
Less

View Lastest Price from FLAVOPIRIDOL HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
FLAVOPIRIDOL HYDROCHLORIDE 131740-09-5
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2018-08-15
Career Henan Chemical Co
Product
FLAVOPIRIDOL HYDROCHLORIDE 131740-09-5
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2018-08-15

131740-09-5, FLAVOPIRIDOL HYDROCHLORIDERelated Search:

CL 82198 HYDROCHLORIDE Diethanolamine Uracil Dihydroxybenzoic acid Resorcinol 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acid Dihydrocaffeic acid Diphenylphosphine oxide Alisertib (MLN8237) SNS-032 Dasatinib PD 0332991 HCl (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol PLX4032 Flavopiridol (Alvocidib) HCl Flavopiridol 2'-chloroflavone ROHITUKINE

  • Flavopiridol hydrochloride, >=98%
  • Alvocidib HCL
  • Flavopiridol (Alvocidib) hydrochloride
  • Flavopiridol hydrochloride hydrate
  • NSC-649890 hydrochloride
  • HL 275; NSC 649890; MDL 107826A; FLAVOPIRIDOL HCL; ALVOCIDIB HYDROCHLORIDE
  • FLAVOPIRIDOL HYDROCHLORIDE
  • FLAVOPIRIDOL HCL
  • Alvocidib Hydrochloride
  • HL 275
  • MDL 107826A
  • NSC 649890
  • rel-(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one Hydrochloride
  • L-86-8276, NSC-649890, (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3s,4r)-3-hydroxy-1-methyl-4-piperidinyl]-4h-1-benzopyran-4-one hydrochloride
  • (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride
  • 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride, (-)-cis-
  • 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy- 1-methyl-4-piperidinyl]-, hydrochloride, rel-
  • Flavopiridol (Alvocidib)hcl
  • Flavopiridol HCI
  • L-86-8276
  • 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one hydrochloride
  • NSC 649890 HCl
  • (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride Flavopiridol hydrochloride
  • Flavopiridol hydrochloride (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride
  • CS-976
  • FLAVOPIRIDOL HYDROCHLORIDE USP/EP/BP
  • 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one,hydrochloride
  • Flavopiridol HC
  • Flavopiridol (L86-8275) HCl
  • 131740-09-5
  • C21H20ClNO5HCl
  • C21H21Cl2NO5
  • Inhibitors
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals