FLAVOPIRIDOL HYDROCHLORIDE

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FLAVOPIRIDOL HYDROCHLORIDE

Product Name: FLAVOPIRIDOL HYDROCHLORIDE
CAS No.: 131740-09-5
Chemical Name: FLAVOPIRIDOL HYDROCHLORIDE
Synonyms: HL 275;CS-976;L-86-8276;NSC 649890;MDL 107826A;Alvocidib HCL;NSC 649890 HCl;Flavopiridol HC;FLAVOPIRIDOL HCL;Flavopiridol HCI
CBNumber: CB1972179
Molecular Formula: C21H21Cl2NO5
Formula Weight: 438.3
MOL File: 131740-09-5.mol

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FLAVOPIRIDOL HYDROCHLORIDE Property

Melting point:: 169.5-170°C
alpha: 24D -1.73 to -3.9°
storage temp.: 2-8°C
solubility: H2O: ~2mg/mL
form: powder
pka: 5.68 ± 0.06(at 25℃)
color: white to light brown
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month
CAS DataBase Reference: 131740-09-5

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
RTECS: DJ2978830

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F3055
Product name: Flavopiridol hydrochloride hydrate
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $156
Updated: 2024/03/01

Sigma-Aldrich

Product number: F3055
Product name: Flavopiridol hydrochloride hydrate
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $586
Updated: 2024/03/01

Cayman Chemical

Product number: 10009197
Product name: Flavopiridol (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 10009197
Product name: Flavopiridol (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 10009197
Product name: Flavopiridol (hydrochloride)
Purity: ≥95%
Packaging: 25mg
Price: $143
Updated: 2024/03/01

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FLAVOPIRIDOL HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Flavopiridol is an orally bioavailable inhibitor of cyclin dependent kinases (IC₅₀s = ~100, ~100, ~100, and 300 nM for Cdk1, Cdk2, Cdk4, and Cdk7, respectively). It also inhibits TEFb, a complex composed of Cdk9 and cyclin T1, with a K_i value of 3 nM. Flavopiridol inhibits transcription of a CMV promoter in HeLa nuclear extract (IC₅₀ = 34 nM), Tat-stimulated transcription of an HIV-1 promotor (IC₅₀ = 7 nM), and HIV-1 replication in HEK239T cells (IC₅₀ = <10 nM). In vivo, flavopiridol (5 mg/kg, i.p.) induces apoptosis and cyclin D1 depletion and delays tumor growth in an HN-12 head and neck carcinoma mouse xenograft model. It also suppresses synovial hyperplasia and joint destruction in a mouse model of collagen-induced arthritis.

Chemical Properties

Yellow Powder

Uses

An inhibitor of cyclin-dependent kinases; the (-)-cis form induces apoptosis in certain tumor cells.

Uses

Flavopiridol hydrochloride hydrate has been used:

as a cyclin-dependent kinase 9 (CDK9) inhibitor to study its effects on histone H3 methylation at lysine 36 (H3K36) and deactivation of transcription in porcine fetal fibroblasts
as an RNA polymerase inhibitor to study its effects on hepatic cells
as RNA transcription inhibitor to study its effects on euchromatin coarsening in zebrafish embryo

Definition

ChEBI: A hydrochloride salt resulting from the formal reaction of equimolar amounts of alvocidib and hydrogen chloride. A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic p aque formation.

Biochem/physiol Actions

Flavopiridol?is a semi-synthetic flavone obtained from Dysoxylum binectariferum that acts as an anti-tumor agent against several cancers. It also shows anti-cancer properties due to which it has been studied in the treatment of acute myeloid leukemia (AML).

storage

Store at +4°C

References

1) Kaur?et al. (1992),?Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275;? J. Natl. Cancer Inst.,?84?1736 2) Cartee?et al. (2002),?Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways;? Mol. Pharmacol.,?61?1313 3) Ambrosini?et al. (2008),?The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner;? Cancer Res.?68?2312 4) Schang?et al. (2004),?Effects of pharmacological cyclin-dependent kinase inhibitors on viral transcription and replication;? Biochim. Biophys. Acta,?1697?197

FLAVOPIRIDOL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from FLAVOPIRIDOL HYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: FLAVOPIRIDOL HYDROCHLORIDE 131740-09-5
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2018-08-15

Career Henan Chemical Co

Product: FLAVOPIRIDOL HYDROCHLORIDE 131740-09-5
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2018-08-15

131740-09-5, FLAVOPIRIDOL HYDROCHLORIDERelated Search:

CL 82198 HYDROCHLORIDE Diethanolamine Uracil Dihydroxybenzoic acid Resorcinol 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acid Dihydrocaffeic acid Diphenylphosphine oxide Alisertib (MLN8237) SNS-032 Dasatinib PD 0332991 HCl (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol PLX4032 Flavopiridol (Alvocidib) HCl Flavopiridol 2'-chloroflavone ROHITUKINE

Flavopiridol hydrochloride, >=98%

Alvocidib HCL

Flavopiridol (Alvocidib) hydrochloride

Flavopiridol hydrochloride hydrate

NSC-649890 hydrochloride

HL 275; NSC 649890; MDL 107826A; FLAVOPIRIDOL HCL; ALVOCIDIB HYDROCHLORIDE

FLAVOPIRIDOL HYDROCHLORIDE

FLAVOPIRIDOL HCL

Alvocidib Hydrochloride

HL 275

MDL 107826A

NSC 649890

rel-(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one Hydrochloride

L-86-8276, NSC-649890, (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3s,4r)-3-hydroxy-1-methyl-4-piperidinyl]-4h-1-benzopyran-4-one hydrochloride

(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride, (-)-cis-

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy- 1-methyl-4-piperidinyl]-, hydrochloride, rel-

Flavopiridol (Alvocidib)hcl

Flavopiridol HCI

L-86-8276

2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one hydrochloride

NSC 649890 HCl

(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride Flavopiridol hydrochloride

Flavopiridol hydrochloride (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride

CS-976

FLAVOPIRIDOL HYDROCHLORIDE USP/EP/BP

2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one,hydrochloride

Flavopiridol HC

Flavopiridol (L86-8275) HCl

131740-09-5

C21H20ClNO5HCl

C21H21Cl2NO5

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