SNS-032
- Product Name
- SNS-032
- CAS No.
- 345627-80-7
- Chemical Name
- SNS-032
- Synonyms
- CS-202;SNS-032;BMS-387032;BMS-3870032;SNS-032, >=99%;BMS-387032/SNS-032;SNS0032(BMS-387032);SNS-032, 98.5%, a selective CDK2 inhibitor;BMS-387032; SNS 032; SNS032; BMS 387032; BMS387032;1-diMethylethyl)-2-oxazolyl]Methyl]thio]-2-thiazolyl]-
- CBNumber
- CB51518701
- Molecular Formula
- C17H24N4O2S2
- Formula Weight
- 380.53
- MOL File
- 345627-80-7.mol
SNS-032 Property
- Melting point:
- 171-173 °C
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 7.33±0.70(Predicted)
- color
- White to Off-White
Safety
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML2218
- Product name
- SNS-032
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $56.52
- Updated
- 2024/03/01
- Product number
- SML2218
- Product name
- SNS-032
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $306
- Updated
- 2024/03/01
- Product number
- 17904
- Product name
- SNS-032
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 17904
- Product name
- SNS-032
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 17904
- Product name
- SNS-032
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $172
- Updated
- 2024/03/01
SNS-032 Chemical Properties,Usage,Production
Description
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. SNS-032 is an ATP-competitive inhibitor of Cdk9, 2, and 7 with IC50 values of 4, 38, and 62 nM, respectively. It is selective for these kinases and displays no additional activity against a panel of 190 kinases (IC50s = >1,000 nM). SNS-032 can block the cell cycle, inhibit transcription, and induce apoptosis in multiple myeloma RPMI-8226 cells with an IC90 value of 0.3 μM. This compound has been shown to induce apoptosis by inhibiting the transcription of the anti-apoptotic proteins, Mcl-1 and XIAP.
Chemical Properties
Off-White Solid
Uses
SNS 032 is a selective inhibitor of Cyclin-dependent Kinase (CDK) 2,7, and 9.
Definition
ChEBI: N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide is a secondary carboxamide resulting from the formal condensation of the carboxy group of piperidine-4-carboxylic acid with the amino group of 5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-amine. It is an ATP-competitive inhibitor of CDK2, CDK7 and CDK9 kinases and exhibits anti-cancer properties. It has a role as an apoptosis inducer, an antineoplastic agent, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor and an angiogenesis inhibitor. It is a piperidinecarboxamide, a member of 1,3-oxazoles, a member of 1,3-thiazoles, an organic sulfide and a secondary carboxamide.
storage
Store at -20°C
References
[1]. tong w.g., chen r., plunkett w., et al. phase i and pharmacologic study of sns-032, a potent and selective cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma. journal of clinical oncology, 2010, 28(18):3015- 3022.
[2]. chipumuro e., marco e., christensen c.l., et al. cdk7 inhibition suppresses super-enhancer-linked oncogenic transcription in mycn-driven cancer. cell, 2014, 159:1-14.
[3]. meng h., jin y.m., liu h., et al. sns-032 inhibits mtorc1/mtorc2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against akt. journal of hematology & oncology, 2013, 6:18.
[4]. chen r., wierda w.g., chubb s., et al. mechanism of action of sns032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. blood, 2009, 113(19):4637-4645.
SNS-032 Preparation Products And Raw materials
Raw materials
Preparation Products
SNS-032 Suppliers
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- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
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- 86-10-82849933
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- China
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- 021-20221225 13917446399
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- QQ:115820162
- sales@zhiwe.net
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- China
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- 021-20908456
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- 021-58180499
- sales@BioChemBest.com
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- China
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- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
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- China
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- 18217
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- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
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- United States
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- 10194
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- 17702719238 17702719238
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- China
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- 0330-2528181
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- 0330-2528171
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- United States
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- 021-50135380
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- China
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- +86 (531) 88811783
- Fax
- +86 (531) 55696010 QQ 1762738062
- sales@trio-pharmatech.com (International market)
- Country
- China
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View Lastest Price from SNS-032 manufacturers
- Product
- N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide 345627-80-7
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 1kg; 10kg; 25kg
- Release date
- 2020-01-07