ChemicalBook > CAS DataBase List > Flavopiridol

Flavopiridol

Product Name
Flavopiridol
CAS No.
146426-40-6
Chemical Name
Flavopiridol
Synonyms
Alvocidib;CS-180;C077990;L86-8275;L-868275;L 868275;Hmr 1275;Flavopirodol;FLAVOPIRIDOL;HMR-1275; L86-8275
CBNumber
CB7362013
Molecular Formula
C21H20ClNO5
Formula Weight
401.84
MOL File
146426-40-6.mol
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Flavopiridol Property

Melting point:
52.5 °C
Boiling point:
603.6±55.0 °C(Predicted)
Density 
1.448±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
insoluble in H2O; ≥40.2 mg/mL in DMSO; ≥85.4 mg/mL in EtOH with gentle warming and ultrasonic
form 
Yellow powder.
pka
6.16±0.40(Predicted)
color 
Light yellow to yellow
InChIKey
BIIVYFLTOXDAOV-YVEFUNNKSA-N
SMILES
C1(C2=CC=CC=C2Cl)OC2=C([C@H]3CCN(C)C[C@H]3O)C(O)=CC(O)=C2C(=O)C=1
CAS DataBase Reference
146426-40-6(CAS DataBase Reference)
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26024
Product name
Flavopiridol
Purity
≥95%
Packaging
5mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
26024
Product name
Flavopiridol
Purity
≥95%
Packaging
25mg
Price
$208
Updated
2024/03/01
Cayman Chemical
Product number
26024
Product name
Flavopiridol
Purity
≥95%
Packaging
50mg
Price
$384
Updated
2024/03/01
Cayman Chemical
Product number
26024
Product name
Flavopiridol
Purity
≥95%
Packaging
100mg
Price
$656
Updated
2024/03/01
Biorbyt Ltd
Product number
orb154639
Product name
Flavopiridol
Purity
>99%
Packaging
100mg
Price
$690.2
Updated
2021/12/16
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Flavopiridol Chemical Properties,Usage,Production

Uses

Antineoplastic (cyclin-dependent kinase inhibitor)[Note—The trivial name, flavopiridol, has appeared in literature].

Uses

Flavopiridol is a synthetic flavonoid derivative, potent inhibitor of CDKs. Inhibitor of CDK9 as a postexposure drug target for adenoviruses.

Definition

ChEBI: Alvocidib is a synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. It has a role as an antineoplastic agent, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an antirheumatic drug and an apoptosis inducer. It is a dihydroxyflavone, a hydroxypiperidine, a member of monochlorobenzenes and a tertiary amino compound. It is a conjugate base of an alvocidib(1+).

Anticancer Research

It is a synthetic derivative of rohitukine plant alkaloid which is obtained fromDysoxylum binectariferum, which is active against leukemia, lymphomas and solidtumors (Shoeb 2006).

Flavopiridol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Flavopiridol manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Flavopiridol 146426-40-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26
Career Henan Chemical Co
Product
Flavopiridol 146426-40-6
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2020-01-09

146426-40-6, FlavopiridolRelated Search:

CHLOROPHOSPHONAZO III Methyl salicylate METSULFURON METHYL Kresoxim-methyl Solvent Red 43 Thiophanate-methyl Tetrahydro-4H-pyran-4-one Tribenuron methyl Centchroman Haloperidol Methyl Flavopiridol (Alvocidib) HCl (R)-3-Hydroxypiperidine hydrocloride Methyl bromide 4H-PYRAN-4-ONE 4-PIPERIDIN-4-YLPHENOL 2'-HYDROXY-5'-ISOPROPYLACETOPHENONE 4-(3-METHYLPHENYL)PIPERIDINE

  • FLAVOPIRIDOL
  • 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3s,4r)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one
  • 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-
  • Alvocidib
  • (-)cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one
  • C077990
  • Hmr 1275
  • L 868275
  • L-868275
  • L86-8275
  • Flavopirodol
  • Flavopiridol(Alvocidib)
  • vopiridol(Alvocidib)
  • 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-Methylpiperidin-4-yl]-4H-chroMen-4-one
  • FLAVOPIRIDOL; HMR-1275;L868275
  • Alvocidib, Free Base
  • Flavopiridol 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one
  • Alvocidib(Flavopiridd)
  • Flavopiridol, >=99%
  • CS-180
  • Flavopiridol (HMR-1275, Alvocidib, L868275)
  • HMR-1275; L86-8275
  • FLAVOPIRIDOL (ALVOCIDIB; L868275; HMR-1275)
  • L868275|||Alvocidib|||NSC 649890 HCl|||HMR-1275
  • Donepezil Impurity 63
  • 146426-40-6
  • C21H20ClNO5
  • API intermediates
  • APIS