ZM 336372

Product Name: ZM 336372
CAS No.: 208260-29-1
Chemical Name: ZM 336372
Synonyms: CS-44;ZM 336372;Zinc00581684;ZM 336372, >=98%;ZM 336372;ZM-336372;ZM 336372 USP/EP/BP;ZM 336372; ZM-336372;ZINC00581684;ZM 336372 - CAS 208260-29-1 - Calbiochem;N-[5-(3-DIMETHYLAMINOBENZAMIDO)-2-METHYLPHENYL]-4-HYDROXYBENZAMIDE;3-(diMethylaMino)-N-(3-(4-hydroxybenzaMido)-4-Methylphenyl)benzaMide
CBNumber: CB6428631
Molecular Formula: C23H23N3O3
Formula Weight: 389.45
MOL File: 208260-29-1.mol

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ZM 336372 Property

Boiling point:: 484.4±45.0 °C(Predicted)
Density: 1.298
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO: >5mg/mL (warmed)
form: powder
pka: 8.31±0.15(Predicted)
color: white to beige
Sensitive: Light Sensitive
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Safety

WGK Germany: 3
HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J65730
Product name: ZM 336372
Packaging: 1mg
Price: $51.9
Updated: 2021/12/16

Alfa Aesar

Product number: J65730
Product name: ZM 336372
Packaging: 5mg
Price: $230
Updated: 2021/12/16

Cayman Chemical

Product number: 10010367
Product name: ZM 336372
Purity: >98%
Packaging: 1mg
Price: $43
Updated: 2024/03/01

Cayman Chemical

Product number: 10010367
Product name: ZM 336372
Purity: >98%
Packaging: 5mg
Price: $85
Updated: 2024/03/01

Sigma-Aldrich

Product number: 692000
Product name: ZM 336372 - CAS 208260-29-1 - Calbiochem
Packaging: 1mg
Price: $230
Updated: 2024/03/01

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ZM 336372 Chemical Properties,Usage,Production

Description

The Ras/Raf-1 signalling pathway is a well-characterized system that links receptor tyrosine kinase (RTK) activation with changes in gene expression and cell behavior. Raf-1 is a serine/threonine protein kinase that phosphorylates and activates MAPK-kinase (MEK) in response to activation by Ras. ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro (IC₅₀ = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells. Activation of the Raf-1 signalling pathway using ZM 336372 in human carcinoid tumor cells results in induction of cell cycle inhibitors and suppression of cellular proliferation.

Uses

It is small molecule tyrosine kinase modulator. ZM336372 induces apoptosis associated with phosphorylation of GSK-3β in pancreatic adenocarcinoma cell lines.

Definition

ChEBI: 3-(dimethylamino)-N-[3-[[(4-hydroxyphenyl)-oxomethyl]amino]-4-methylphenyl]benzamide is a member of benzamides.

References

1) Hall-Jackson et al. (1999), Paradoxical activation of Raf by a novel Raf inhibitor; Chem. Biol., 6 559 2) Deming et al. (2010), ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines; J. Surg. Res., 161 28

ZM 336372 Preparation Products And Raw materials

Raw materials

Preparation Products

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ZM 336372 Suppliers

Canada 1 China 112 Germany 1 India 2 Japan 2 Switzerland 1 United Kingdom 3 United States 22 Global 144

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
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J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
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Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
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Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Tel: 21-57721279
Fax: QQ：14057904
Email: sales@shydchem.com.cn
Country: China
ProdList: 990
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VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
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Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
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Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
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Shanghai Sphchem Co., Ltd.

Tel: 21-21-56491756 13512199871
Fax: 021-5649-1756
Email: sales@panhongchem.com
Country: China
ProdList: 4000
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
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View Lastest Price from ZM 336372 manufacturers

Career Henan Chemical Co

Product: N-[5-(3-DIMETHYLAMINOBENZAMIDO)-2-METHYLPHENYL]-4-HYDROXYBENZAMIDE 208260-29-1
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 96%
Supply Ability: 10kg
Release date: 2019-09-04

208260-29-1, ZM 336372Related Search:

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N-[5-(3-DIMETHYLAMINOBENZAMIDO)-2-METHYLPHENYL]-4-HYDROXYBENZAMIDE

ZM 336372

Zinc00581684

3-(DIMETHYLAMINO)-N-[3-[(4-HYDROXYBENZOYL)-AMINO]-4-METHYLPHENYL]BENZAMIDE

3-(diMethylaMino)-N-(3-(4-hydroxybenzaMido)-4-Methylphenyl)benzaMide

Benzamide, 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-

ZM 336372 3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]benzamide

ZM 336372, >=98%

ZM 336372;ZM-336372

ZM 336372 - CAS 208260-29-1 - Calbiochem

CS-44

ZM 336372; ZM-336372;ZINC00581684

ZM 336372 USP/EP/BP

208260-29-1

08260-29-1

C23H23N3O3

Inhibitors

MAPK

A potent and specific inhibitor of the protein kinase c-Raf.

Amines

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals