ChemicalBook > CAS DataBase List > ZM 336372

ZM 336372

Product Name
ZM 336372
CAS No.
208260-29-1
Chemical Name
ZM 336372
Synonyms
CS-44;ZM 336372;Zinc00581684;ZM 336372, >=98%;ZM 336372;ZM-336372;ZM 336372 USP/EP/BP;ZM 336372; ZM-336372;ZINC00581684;ZM 336372 - CAS 208260-29-1 - Calbiochem;N-[5-(3-DIMETHYLAMINOBENZAMIDO)-2-METHYLPHENYL]-4-HYDROXYBENZAMIDE;3-(diMethylaMino)-N-(3-(4-hydroxybenzaMido)-4-Methylphenyl)benzaMide
CBNumber
CB6428631
Molecular Formula
C23H23N3O3
Formula Weight
389.45
MOL File
208260-29-1.mol
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ZM 336372 Property

Boiling point:
484.4±45.0 °C(Predicted)
Density 
1.298
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
DMSO: >5mg/mL (warmed)
form 
powder
pka
8.31±0.15(Predicted)
color 
white to beige
Sensitive 
Light Sensitive
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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Safety

WGK Germany 
3
HS Code 
2924297099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J65730
Product name
ZM 336372
Packaging
1mg
Price
$51.9
Updated
2021/12/16
Alfa Aesar
Product number
J65730
Product name
ZM 336372
Packaging
5mg
Price
$230
Updated
2021/12/16
Cayman Chemical
Product number
10010367
Product name
ZM 336372
Purity
>98%
Packaging
1mg
Price
$43
Updated
2024/03/01
Cayman Chemical
Product number
10010367
Product name
ZM 336372
Purity
>98%
Packaging
5mg
Price
$85
Updated
2024/03/01
Sigma-Aldrich
Product number
692000
Product name
ZM 336372 - CAS 208260-29-1 - Calbiochem
Packaging
1mg
Price
$230
Updated
2024/03/01
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ZM 336372 Chemical Properties,Usage,Production

Description

The Ras/Raf-1 signalling pathway is a well-characterized system that links receptor tyrosine kinase (RTK) activation with changes in gene expression and cell behavior. Raf-1 is a serine/threonine protein kinase that phosphorylates and activates MAPK-kinase (MEK) in response to activation by Ras. ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro (IC50 = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells. Activation of the Raf-1 signalling pathway using ZM 336372 in human carcinoid tumor cells results in induction of cell cycle inhibitors and suppression of cellular proliferation.

Uses

It is small molecule tyrosine kinase modulator. ZM336372 induces apoptosis associated with phosphorylation of GSK-3β in pancreatic adenocarcinoma cell lines.

Definition

ChEBI: 3-(dimethylamino)-N-[3-[[(4-hydroxyphenyl)-oxomethyl]amino]-4-methylphenyl]benzamide is a member of benzamides.

References

1) Hall-Jackson et al. (1999), Paradoxical activation of Raf by a novel Raf inhibitor; Chem. Biol., 6 559 2) Deming et al. (2010), ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines; J. Surg. Res., 161 28

ZM 336372 Preparation Products And Raw materials

Raw materials

Preparation Products

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ZM 336372 Suppliers

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View Lastest Price from ZM 336372 manufacturers

Career Henan Chemical Co
Product
N-[5-(3-DIMETHYLAMINOBENZAMIDO)-2-METHYLPHENYL]-4-HYDROXYBENZAMIDE 208260-29-1
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
96%
Supply Ability
10kg
Release date
2019-09-04

208260-29-1, ZM 336372Related Search:

Urea, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)Methyl]-2-Methyl-1-piperazinyl]-2-oxoethoxy]phenyl]- N-(4-PHENYLSULFONYLPHENYL)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDE ZM223 Z-ORN(BOC)-OH ZPCK ZM 323881 hydrochloride ZM 39923 HCl ZM 241385 ZM 306416 SB216763 ZM 447439 Quizartinib (AC220) ZOTAROLIMUS Z-N-Methyl-D-valine Z-NVA-OH ZM 39923 HYDROCHLORIDE Z-NLE-OH ZM306416

  • N-[5-(3-DIMETHYLAMINOBENZAMIDO)-2-METHYLPHENYL]-4-HYDROXYBENZAMIDE
  • ZM 336372
  • Zinc00581684
  • 3-(DIMETHYLAMINO)-N-[3-[(4-HYDROXYBENZOYL)-AMINO]-4-METHYLPHENYL]BENZAMIDE
  • 3-(diMethylaMino)-N-(3-(4-hydroxybenzaMido)-4-Methylphenyl)benzaMide
  • Benzamide, 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-
  • ZM 336372 3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]benzamide
  • ZM 336372, >=98%
  • ZM 336372;ZM-336372
  • ZM 336372 - CAS 208260-29-1 - Calbiochem
  • CS-44
  • ZM 336372; ZM-336372;ZINC00581684
  • ZM 336372 USP/EP/BP
  • 208260-29-1
  • 08260-29-1
  • C23H23N3O3
  • Inhibitors
  • MAPK
  • A potent and specific inhibitor of the protein kinase c-Raf.
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals