SB216763
- Product Name
- SB216763
- CAS No.
- 280744-09-4
- Chemical Name
- SB216763
- Synonyms
- CS-332;SB 216763;SB216763 USP/EP/BP;SB-216763(SB 216763);3-(2,4-Dichlorophenyl)-4-...;GSK-3 Inhibitor IV, SB-216763;3-(1-methyl-indol-3-yl)-4-(2,4-dichloro-phenyl-)-maleimide;GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem;3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione;3-(2,4-DICHLOROPHENYL)-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
- CBNumber
- CB9493416
- Molecular Formula
- C19H12Cl2N2O2
- Formula Weight
- 371.22
- MOL File
- 280744-09-4.mol
SB216763 Property
- Melting point:
- 287-288.6 °C(lit.)
- Boiling point:
- 598.1±50.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: 20 mg/mL, soluble
- form
- Orange solid
- pka
- 7.27±0.60(Predicted)
- color
- orange
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- S3442
- Product name
- SB 216763
- Purity
- >98% (HPLC)
- Packaging
- 5mg
- Price
- $178
- Updated
- 2024/03/01
- Product number
- S3442
- Product name
- SB 216763
- Purity
- >98% (HPLC)
- Packaging
- 25mg
- Price
- $708
- Updated
- 2024/03/01
- Product number
- B5716
- Product name
- SB 216763
- Purity
- >98.0%(HPLC)
- Packaging
- 10mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- B5716
- Product name
- SB 216763
- Purity
- >98.0%(HPLC)
- Packaging
- 50mg
- Price
- $352
- Updated
- 2024/03/01
- Product number
- 10010246
- Product name
- SB 216763
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $73
- Updated
- 2024/03/01
SB216763 Chemical Properties,Usage,Production
Description
SB-216763 (280744-09-4) is a potent and selective inhibitor of glycogen synthase kinase-1 (GSK-3) IC50=34.3 nM.1 Acts at the ATP-binding domain. Displays protective effects in lung fibrosis mouse model.2 Displays neuroprotective effects on cultured neurons.3 SB-216763 maintains mouse embryonic stem cells in a pluripotent state.4?Cell permeable.
Uses
SB 216763 is a potent and selective cell permeale ATP-competitive inhibitor of GSK3a. It stimulates glycogen synthesis in Chang human liver cells.
Uses
SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line and colorectal cancer cells.
Definition
ChEBI: 3-(2,4-dichlorophenyl)-4-(1-methyl-3-indolyl)pyrrole-2,5-dione is a member of indoles and a member of maleimides.
Biological Activity
Potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (K i = 9 nM for GSK-3 α ); competes with ATP. Has minimal activity against 24 other protein kinases (IC 50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.
Biochem/physiol Actions
SB-216763 is a small molecule that competes with ATP and potently inhibits the activity α and β isozymes of GSK-3. It acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. It also delays preconditioning, reduces infarct size and prevents cardiac ischemia.
storage
Room temperature
References
1) Coghlan et al. (2000), Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription; Chem. Biol., 7 793 2) Gurrieri et al. (2010), 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis; J. Pharmacol. Exp. Ther., 332 785 3) Cross et al. (2001), Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurons from death; J. Neurochem., 77 94 4) Kirby et al. (2012), Glycogen synthase kinase 3 (GSK3) inhibitor , SB-216763, promotes pluripotency in mouse embryonic stem cells; PLoS One, 7 e39329
SB216763 Preparation Products And Raw materials
Raw materials
Preparation Products
SB216763 Suppliers
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View Lastest Price from SB216763 manufacturers
- Product
- SB216763 280744-09-4
- Price
- US $19.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2021-09-24
- Product
- SB216763 280744-09-4
- Price
- US $19.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2021-11-26
- Product
- SB216763 280744-09-4
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23