SB 743921

Product Name: SB 743921
CAS No.: 940929-33-9
Chemical Name: SB 743921
Synonyms: CS-1972;SB 743921;SB-743921 HCl;SB 743921 USP/EP/BP;SB 743921 hydrochloride;SB743921;SB743921; SB 743921;SB-743921 hydrochloride hcl SB743921;(R)-N-(3-Aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl)-4-methylb;(R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl)-4-methylbenzamide hydrochloride;SB 743921; (R)-N-(3-AMINOPROPYL)-N-(1-(3-BENZYL-7-CHLORO-4-OXO-4H-CHROMEN-2-YL)-2-METHYLPROPYL)-4-METHYLBENZAMIDE HYDROCHLORIDE
CBNumber: CB52517941
Molecular Formula: C31H34Cl2N2O3
Formula Weight: 553.51926
MOL File: 940929-33-9.mol

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SB 743921 Property

storage temp.: -20°C
solubility: H2O: soluble5mg/mL, clear
form: powder
color: white to beige
InChIKey: MLMZVWABFOLFGV-LNLSOMNWSA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1121
Product name: SB743921 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $254
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1121
Product name: SB743921 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $807
Updated: 2024/03/01

Cayman Chemical

Product number: 18384
Product name: SB-743921 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18384
Product name: SB-743921 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 18384
Product name: SB-743921 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $278
Updated: 2024/03/01

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SB 743921 Chemical Properties,Usage,Production

Uses

SB 743921 Hydrochloride is a mitotic kinesin inhibitor, which can be used to treat lung disease in combination with other therapy.

Biological Activity

sb743921 is an inhibitor of kinesin spindle protein (ksp) with ki value of 0.1nm [1].as an inhibitor of mitotic kinesin ksp, sb743921 causes cell cycle arrest in mitosis, results in cell death. sb743921 is developed to treat for cancers. sb743921 is a potent and selective inhibitor. in the affinity assays, sb743921 shows ki values of 0.1nm and 0.12nm for human ksp and mouse ksp, respectively. it has no affinity with other kinesins. in the cellular assay, sb743921 exerts anti-proliferation efficacy in skov3, colo205, mv522 and mx1 with ic50 values of 0.02nm, 0.07nm, 1.7nm and 0.06nm. moreover, sb743921 is shown to have activity against human tumor xenografts colo205, mcf-7, sk-mes, h69, ovcar-3, ht-29, mda-mb-231 and a2780. sb743921 is also effective against p388 lymphocytic leukemia xenografts in mice [1].

References

[1] jackson j r, gilmartin a, dhanak d, et al. a second generation ksp inhibitor, sb-743921, is a highly potent and active therapeutic in preclinical models of cancer. proceedings of the american association for cancer research, 2006, 2006(2): b11.

SB 743921 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB 743921 Suppliers

China 75 China Hong Kong 1 India 1 United Kingdom 1 United States 15 Global 93

Zhengzhou HSH Science & Technology Co., Ltd.

Tel: 0371-55932928 18937192232
Fax: 0086-0371-55932928
Email: 1282296214@qq.com
Country: China
ProdList: 496
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Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
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Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
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Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4647
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Dtchem Laboratories,（Gan Su）Co.,Ltd.

Tel: 18993966060
Fax: 0943-8288977
Email: sales@techbiochem.com
Country: China
ProdList: 944
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Shanghai civi chemical technology co.,Ltd

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Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9872
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NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1494
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Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9901
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
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View Lastest Price from SB 743921 manufacturers

Career Henan Chemical Co

Product: SB 743921 940929-33-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-02

940929-33-9, SB 743921Related Search:

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SB 743921

(R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl)-4-methylbenzamide hydrochloride

SB 743921; (R)-N-(3-AMINOPROPYL)-N-(1-(3-BENZYL-7-CHLORO-4-OXO-4H-CHROMEN-2-YL)-2-METHYLPROPYL)-4-METHYLBENZAMIDE HYDROCHLORIDE

N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methylbenzamide hydrochloride

SB 743921 hydrochloride

N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methylbenzamide hydrochloride SB 743921

SB 743921 N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methylbenzamide hydrochloride

SB-743921 HCl

SB743921;SB743921; SB 743921

(R)-N-(3-Aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl)-4-methylb

CS-1972

SB 743921 USP/EP/BP

SB-743921 hydrochloride hcl SB743921

940929-33-9

C31H33ClN2O3HCl

C31H33N2O3HCl

C31H34Cl2N2O3

Inhibitors

apis