SB408124

Product Name: SB408124
CAS No.: 288150-92-5
Chemical Name: SB408124
Synonyms: CS-1990;SB 408124;SB 408214;SB408124 USP/EP/BP;SB 408124; SB408124;SB-408124, CID4331799;SB-408124 >=98% (HPLC), solid;1-(6,8-difluoro-2-methylquinolin-4-yl)-3-(4-(dimethylamino)phenyl)urea;N-(6,8-DIFLUORO-2-METHYL-4-QUINOLINYL)-N'-[4-(DIMETHYLAMINO)PHENYL]UREA;Urea, N-(6,8-difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]-
CBNumber: CB4445874
Molecular Formula: C19H18F2N4O
Formula Weight: 356.37
MOL File: 288150-92-5.mol

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SB408124 Property

Boiling point:: 430.3±45.0 °C(Predicted)
Density: 1.371
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: ~24 mg/mL
form: solid
pka: 12.12±0.43(Predicted)
color: olive-green

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S2694
Product name: SB-408124
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $207
Updated: 2024/03/01

Sigma-Aldrich

Product number: S2694
Product name: SB-408124
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $565
Updated: 2024/03/01

Cayman Chemical

Product number: 22961
Product name: SB-408124
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 22961
Product name: SB-408124
Purity: ≥98%
Packaging: 10mg
Price: $143
Updated: 2024/03/01

Cayman Chemical

Product number: 22961
Product name: SB-408124
Purity: ≥98%
Packaging: 25mg
Price: $317
Updated: 2024/03/01

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SB408124 Chemical Properties,Usage,Production

Uses

SB 408124 is a novel OX-1 antagonist.

Definition

ChEBI: 1-(6,8-difluoro-2-methyl-4-quinolinyl)-3-[4-(dimethylamino)phenyl]urea is a member of quinolines and an organohalogen compound.

Biological Activity

Selective non-peptide orexin OX 1 receptor antagonist (K b values are 21.7 and 1405 nM for human OX 1 and OX 2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo .

storage

Store at RT

References

[1] langmead cj1, jerman jc, brough sj, scott c, porter ra, herdon hj.characterisation of the binding of [3h]-sb-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. br j pharmacol. 2004 jan;141(2):340-6.
[2] woldan-tambor a1, biegańska k, wiktorowska-owczarek a, zawilska jb. activation of orexin/hypocretin type 1 receptors stimulates camp synthesis in primary cultures of rat astrocytes. pharmacol rep. 2011;63(3):717-23.
[3] kis gk1, molnár ah, daruka l, gardi j, rákosi k, lászló f, lászló fa, varga c.the osmotically and histamine-induced enhancement of the plasma vasopressin level is diminished by intracerebroventricularly administered orexin in rats. pflugers arch. 2012 apr;463(4):531-6.

SB408124 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB408124 Suppliers

China 73 Germany 2 India 2 Switzerland 1 United Kingdom 3 United States 13 Global 94

Shanghai Boyle Chemical Co., Ltd.

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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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MedChemexpress LLC

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Guangzhou Isun Pharmaceutical Co., Ltd

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ShangHai KenEn Chemical Technology Co., Ltd.

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288150-92-5, SB408124Related Search:

SB 743921 Suvorexant 4-AMINO-8-FLUORO-2-METHYLQUINOLINE SB408124 4-AMINO-6,8-DIFLUORO-2-METHYLQUINOLINE 8-Fluoro-2-Methyl-Quinoline 4-AMINO-6-FLUORO-2-METHYLQUINOLINE 4-AMINO-8-FLUOROQUINOLINE

1-(6,8-difluoro-2-methylquinolin-4-yl)-3-(4-(dimethylamino)phenyl)urea

SB 4081241-(6,8-difluoro-2-methylquinolin-4-yl)-3-(4-(dimethylamino)phenyl)urea

N-(6,8-DIFLUORO-2-METHYL-4-QUINOLINYL)-N'-[4-(DIMETHYLAMINO)PHENYL]UREA

SB 408124

SB-408124, CID4331799

CS-1990

SB 408124; SB408124

Urea, N-(6,8-difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]-

SB-408124 >=98% (HPLC), solid

SB408124 USP/EP/BP

SB 408214

Urea, N-(6,8-difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]-

288150-92-5

C19H18F2N4O

Inhibitors

Orexin receptor