2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride

Product Name: 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride
CAS No.: 694433-59-5
Chemical Name: 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride
Synonyms: CS-872;SB505124 ，S2186;SB505124;SB505124;SB-505124, 10 mM in DMSO;SB 505124, ALK5 inhibitor;SB-505124 hydrochloride hydrate;SB-505124 hydrate hydrochloride;SB-505124 hydrochloride hydrate SB505124;SB-505124, 98%, a selective inhibitor of TGFβR for ALK4, ALK5;2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-iMidazol-4-yl)-6-Methylpyridine
CBNumber: CB12100798
Molecular Formula: C20H21N3O2
Formula Weight: 335.4
MOL File: 694433-59-5.mol

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2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride Property

Melting point:: 168 °C
Boiling point:: 509.7±50.0 °C(Predicted)
Density: 1.202
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: >10mg/mL
form: powder
pka: 11.26±0.10(Predicted)
color: yellow
InChI: 1S/C20H21N3O2.ClH.H2O/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15;;/h5-10H,11H2,1-4H3,(H,22,23);1H;1H2
InChIKey: DIDCCMVWCVRTNB-UHFFFAOYSA-N
SMILES: O.Cl.Cc1cccc(n1)-c2[nH]c(nc2-c3ccc4OCOc4c3)C(C)(C)C

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29349990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S4696
Product name: SB-505124 hydrochloride hydrate
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $300
Updated: 2026/03/19

Sigma-Aldrich

Product number: S4696
Product name: SB-505124 hydrochloride hydrate
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $1050
Updated: 2026/03/19

TCI Chemical

Product number: B6056
Product name: SB-505124
Packaging: 5MG
Price: $76
Updated: 2026/03/19

TCI Chemical

Product number: B6056
Product name: SB-505124
Packaging: 25MG
Price: $275
Updated: 2026/03/19

Cayman Chemical

Product number: 11793
Product name: SB-505124
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

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2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride Chemical Properties,Usage,Production

Description

SB-505124 inhibits the TGF-β1 receptor serine/threonine kinase ALK5 with an IC₅₀ value of 47 nM. Though it is a less potent antagonist of ALK4 (IC₅₀ = 129 nM) and ALK7, SB-505124 selectively and concentration-dependently inhibits ALK4-, ALK5-, and ALK7-dependent activation of downstream SMAD2 and SMAD3 and TGF-β–induced MAP kinase pathway components without altering ALK1-3 or ALK6-induced SMAD signaling. In an assay determining in vitro phosphorylation of SMAD3, SB-505124 is more potent than SB-431452 with IC₅₀ values of 47 versus 94 nM, respectively.

Uses

SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptor ALK5 and as well as being a selective inhibitor of ALK4 but with less potency. SB-505124 blocks TGF-β–induced apoptosis of FaO cells and NRP 154 cells in a concentration-dependent manner. SB-505124 has been shown to suppress the migration and invasion of breast cancer MCF-7-M5 cells.

Uses

SB-505124 inhibits the TGF-β1 receptor serine/threonine kinase ALK5 with an IC50 value of 47 nM. Though it is a less potent antagonist of ALK4 (IC50 = 129 nM) and ALK7, SB-505124 selectively and concentration-dependently inhibits ALK4-, ALK5-, and ALK7-dependent activation of downstream SMAD2 and SMAD3 and TGF-β–induced MAP kinase pathway components without altering ALK1-3 or ALK6-induced SMAD signaling. In an assay determining in vitro phosphorylation of SMAD3, SB-505124 is more potent than SB-431452 with IC50 values of 47 versus 94 nM, respectively.

Uses

SB-505124 hydrochloride hydrate was used to study the role of TGF-β pathway in development and differentiation studies.^3,4

Definition

ChEBI: SB 505124 is a member of the class of imidazoles carrying tert-butyl, 1,3-benzodioxol-5-yl and 6-methylpyridin-2-yl substituents at positions 2, 4 and 5 respectively. It has a role as a TGFbeta receptor antagonist. It is a member of imidazoles, a benzodioxole and a member of methylpyridines.

Biochem/physiol Actions

SB-505124 selectively inhibits TGF-β type I receptors, activin receptor-like kinases (ALK) 4, 5 and 7. It inhibits ALK4-, 5- and 7-mediated activation of Smad2, Smad3 and MAPK pathway induced by TGF-β.1 SB-505124 inhibits the human fibroblast trans-differentiation induced by the co-culture with Esophageal squamous cell carcinoma.2

storage

Store at -20°C

References

[1] STACEY DACOSTA BYFIELD. SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.[J]. Molecular Pharmacology, 2004, 65 3: 744-752. DOI: 10.1124/mol.65.3.744
[2] JENNIFER SAPITRO. Suppression of transforming growth factor-β effects in rabbit subconjunctival fibroblasts by activin receptor-like kinase 5 inhibitor.[J]. Molecular Vision, 2010: 1880-1892.

2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride Suppliers

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View Lastest Price from 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride manufacturers

Career Henan Chemical Co

Product: 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride 694433-59-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-18

694433-59-5, 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochlorideRelated Search:

2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride SB 242084 (hydrochloride) SB 415286 SB 202190 SB 431542 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime SB 269970 HYDROCHLORIDE SB1317 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 4'-CHLORO-3-METHOXYCINNAMANILIDE SB-705498 SB 203580 SB242235 Ispinesib MK-2206 2HCl LY2109761 Veliparib

2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride

SB-505124 hydrate hydrochloride

2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-iMidazol-4-yl)-6-Methylpyridine

2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1- diMethylethyl)-1H-iMidazol-5-yl]-6-Methyl-pyridine

2-[4-(1,3-Benzodioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl]-6-methylpyridine

SB-505124, 98%, a selective inhibitor of TGFβR for ALK4, ALK5

SB-505124 hydrochloride hydrate

2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine

2-[4-(1,3-Benzodioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl]-6-methylpyridine SB505124

2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride hydrate

SB505124;SB505124

CS-872

Pyridine, 2-[4-(1,3-benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-

2-[5-(Benzo[d][1,3]dioxol-5-yl)-2-(tert-butyl)-1H-imidazol-4-yl]-6-methylpyridine

SB-505124 hydrochloride hydrate SB505124

SB 505124, ALK5 inhibitor

SB-505124, 10 mM in DMSO

SB505124 ，S2186

694433-59-5

Inhibitors

Smad

TGF-beta

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Tyrosine Kinase Inhibitors