Veliparib
Abstract Biological activity In vitro In vivo Features References- Product Name
- Veliparib
- CAS No.
- 912444-00-9
- Chemical Name
- Veliparib
- Synonyms
- API VELIPARIB;100936;CS-301;A861695;Veliparib;NSC 737664;ABT-888 2HCl;Veliparib Base;VELIPARIBABT-888;Veliparib, >=98%
- CBNumber
- CB22489643
- Molecular Formula
- C13H16N4O
- Formula Weight
- 244.29
- MOL File
- 912444-00-9.mol
Veliparib Property
- Boiling point:
- 579.0±40.0 °C(Predicted)
- Density
- 1.274
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥10.6 mg/mL in EtOH with ultrasonic; ≥6.11 mg/mL in DMSO
- form
- solid
- pka
- 9.22±0.30(Predicted)
- color
- White to off-white
- CAS DataBase Reference
- 912444-00-9
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H341Suspected of causing genetic defects
H361Suspected of damaging fertility or the unborn child
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P281Use personal protective equipment as required.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313IF exposed or concerned: Get medical advice/attention.
P314Get medical advice/attention if you feel unwell.
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 001028
- Product name
- Veliparib
- Packaging
- 10mg
- Price
- $212
- Updated
- 2021/12/16
- Product number
- A112580
- Product name
- ABT888
- Packaging
- 250mg
- Price
- $340
- Updated
- 2021/12/16
- Product number
- X7540
- Product name
- Veliparib
- Packaging
- 100mg
- Price
- $384
- Updated
- 2021/12/16
- Product number
- FV16903
- Product name
- Veliparib
- Packaging
- 500mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- A3002
- Product name
- ABT-888(Veliparib)
- Packaging
- 50mg
- Price
- $219
- Updated
- 2021/12/16
Veliparib Chemical Properties,Usage,Production
Abstract
Veliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor. It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer treatments.
Veliparib (ABT-888) is being investigated to treat squamous and non-squamous non-small cell lung cancer, BRCA breast cancer, triple negative breast cancer and ovarian cancer.
Biological activity
Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.
In vitro
Veliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor，which inhibits PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays，respectively.ABT-888 reduces clonogenic survival and inhibits DNA repair in H460 cells. ABT-888 inhibits the PARP activity with EC50 of 2 nM in C41 cells.
In vivo
ABT-888 inhibits PARP in B16F10 and 9L xenograft models, thus enhancing the anticancer activity of temozolomide. The Combined with other cytotoxic agents, ABT-888 shows strong antitumor effect in MX-1 xenograft model. ABT-888 reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg according to the the size of tumors in A375 and Colo829 xenograft models.
Features
ABT-888 enhances the effectiveness of common cancer treatments, such as radiation therapy and alkylating agents.
References
https://www.abbvie.com/our-science/pipeline/veliparib.html
https://en.wikipedia.org/wiki/Veliparib
Chemical Properties
Off-White Solid
Uses
ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo.
Definition
ChEBI: A benzimidazole substituted with a carbamoyl group at C-4 and a (2R)-2-methylpyrrolidin-2-yl moiety at C-2. It is a potent, orally bioavailable PARP inhibitor.
Biological Activity
abt-888, also named as veliparib, is poly (adp-ribose) polymerase (parp) inhibitor and has demonstrated excellent in vivo efficacy in a broad spectrum of preclinical tumor models in combination with a variety of cytotoxic agents. parp is involved in dna repair and elevated parp levels can result in resistance to cytotoxic chemotherapy and radiation. so, parp inhibitors hold promise as chemotherapy and radiation sensitizers. abt-888 is also active on microsatellite instability (msi) cell lines harboring mutations in both mre11 and rad50 genes compared to microsatellite stable (mss) cell lines (wild-type for both genes).shivaani kummar, robert kinders, martin e. gutierrez, larry rubinstein, ralph e. parchment, lawrence r. phillips, jiuping ji, anne monks, jennifer a. low, alice chen, anthony j. murgo, jerry collins, seth m. steinberg, helen eliopoulos, vincent l. giranda, gary gordon, lee helman, robert wiltrout, joseph e. tomaszewski and james h. doroshow. phase 0
Veliparib Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Veliparib manufacturers
- Product
- Veliparib 912444-00-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%, Single impurity＜0.1
- Supply Ability
- 1 ton
- Release date
- 2023-12-26
- Product
- Veliparib (ABT-888) 912444-00-9
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98% HPLC
- Supply Ability
- 1kg
- Release date
- 2023-08-02
- Product
- Veliparib (ABT-888) 912444-00-9
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-02