ABT-888

Product Name: ABT-888
CAS No.: 912445-05-7
Chemical Name: ABT-888
Synonyms: ABT-88;ABT-888;Willipani;ABT888 HCl;Veliparib HCl;Veliparib 2HCl;ABT 888;ABT888;ABT888(2HCl salt);ABT-888 USP/EP/BP;ABT888(Veliparib HCL)
CBNumber: CB42473798
Molecular Formula: C13H16N4O
Formula Weight: 244.296
MOL File: 912445-05-7.mol

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ABT-888 Property

Melting point:: >173°C (dec.)
storage temp.: Refrigerator
solubility: Methanol (Slightly, Heated), THF (Slightly, Heated)
form: Colorless to white crystalline solid.
color: Off-White to Dark Yellow
InChI: InChI=1/C13H16N4O/c1-7-5-6-15-10(7)13-16-9-4-2-3-8(12(14)18)11(9)17-13/h2-4,7,10,15H,5-6H2,1H3,(H2,14,18)(H,16,17)/t7-,10?/s3
InChIKey: FXRVOXLVQCUUGN-IEOOLIIMNA-N
SMILES: C1=C(C(=O)N)C2=C(NC(C3[C@H](C)CCN3)=N2)C=C1 |&1:10,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11505
Product name: ABT-888 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 11505
Product name: ABT-888 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 11505
Product name: ABT-888 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $142
Updated: 2024/03/01

Cayman Chemical

Product number: 11505
Product name: ABT-888 (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $267
Updated: 2024/03/01

Tocris

Product number: 7026
Product name: Veliparibdihydrochloride
Purity: ≥98%(HPLC)
Packaging: 50
Price: $125
Updated: 2021/12/16

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ABT-888 Chemical Properties,Usage,Production

Uses

ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo. Potent PARP inhibitor.

in vivo

The oral bioavailability of Veliparib is 56%-92% in mice, SD rats, beagle dogs, and cynomolgus monkeys after oral administration^[1]. Veliparib (25 mg/kg, i.p.) can improve tumor growth delay in a NCI-H460 xenograft model. Combination with radiation, veliparib decreases the tumor vessel formation^[3]. Veliparib reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg in A375 and Colo829 xenograft models and the suppression can be maintained over time^[4].

IC 50

PARP-2: 2.9 nM (Ki); PARP-1: 5.2 nM (Ki)

storage

Store at -20°C

ABT-888 Preparation Products And Raw materials

Raw materials

Preparation Products

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ABT-888 Suppliers

China 164 India 2 United Kingdom 2 United States 20 Global 188

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Hangzhou Zyter Biological & Chemical Technology Co., Ltd.

Tel: 18858184290; 18858184290
Fax: 0086-571-28313105
Email: sales@zyterpharm.com
Country: China
ProdList: 48
Advantage: 49

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
Country: China
ProdList: 4267
Advantage: 65

Shanghai AmasPharm Co., Ltd.

Tel: 021-54540637 18621091017
Fax: 021-34978309
Email: sales@amaspharm.com
Country: China
ProdList: 781
Advantage: 62

ZhengZhou HuaWen Chemical Co.Ltd

Tel: 0370-2785118 17550508557
Fax: QQ：3470079902
Email: 675141927@qq.com
Country: China
ProdList: 3199
Advantage: 55

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

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View Lastest Price from ABT-888 manufacturers

Nanjing Fred Technology Co., Ltd

Product: Veliparib dihydrochloride 912445-05-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%, Single impurity＜0.1
Supply Ability: 1 ton
Release date: 2023-12-26

Guangzhou Biocar Biotechnology Co.,Ltd.

Product: ABT-888 912445-05-7
Price: US $1.00/g
Min. Order: 10g
Purity: 99.5%
Supply Ability: 1000kg
Release date: 2022-01-10

Career Henan Chemical Co

Product: ABT-888 912445-05-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-20

912445-05-7, ABT-888Related Search:

Veliparib ABT 263 1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE PJ-34 PF-01367338 Benzamide Minocycline hydrochloride 1,5-ISOQUINOLINEDIOL 1(2H)-Isoquinolinone, 5-aMino-, Monohydrochloride PLX4032 4-AMINO-1,8-NAPHTHALIMIDE 3-Aminobenzamide NU1025 4-Hydroxyquinazoline Rucaparib DPQ ABT-199 Velpatasvir

ABT-888

2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide,dihydrochloridesalt

2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride

Veliparib dihydrochloride

ABT-888(Veliparib dihydrochloride)

ABT-888 dihydrochloride

ABT888 HCl

Veliparib hydrochloride

2-[(2S)-2-Methyl-2-pyrrolidinyl]-1H-benziMidazole-4-carboxaMide

(R)-2-(2-Methylpyrrolidin-2-yl)-1H-benimidazole-4-carboxamide dihydrochloride (VELIPARIB)

1H-Benzimidazole-7-carboxamide, 2-[(2R)-2-methyl-2-pyrrolidinyl]-, hydrochloride (1:2)

Veliparib (ABT-888) dihydrochloride

2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-7-carboxamide dihydrochloride

Veliparib 2HCl

2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide,dihydrochloride

(R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide dihydrochloride

Veliparib dihydrochloride, >=98%

ABT-88

ABT888(Veliparib HCL)

ABT 888;ABT888

ABT888(2HCl salt)

Veliparib (ABT-888 hydrochloride)

Willipani

ABT 888 dihydrochloride - Veliparib dihydrochloride | A 861695 dihydrochloride

Veliparib HCl

ABT-888 USP/EP/BP

Veliparib dihydrochloride salt

Veliparibdihydrochloride/ABT-888

(R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-7-carboxamide dihydrochloride

Veliparib dihydrochloride, 10 mM in DMSO

912445-05-7

Inhibitors

Inhibitor

API