Velpatasvir

Product Name: Velpatasvir
CAS No.: 1377049-84-7
Chemical Name: Velpatasvir
Synonyms: GS 5816;CS-2204;Vipatavir;Vipataivir;Velpatasvir;MFCD28411371;Velpatasvir API;GS 5816;GS-5816;Velpatasvir(PVP);Unifiram (DM-232)
CBNumber: CB62743053
Molecular Formula: C49H54N8O8
Formula Weight: 883
MOL File: 1377049-84-7.mol

More

Less

Velpatasvir Property

Melting point:: >170oC (dec.)
Density: 1.314±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
form: solid
pka: 10.75±0.46(Predicted)
color: Pale yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H413May cause long lasting harmful effects to aquatic life

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 21280
Product name: Velpatasvir
Purity: ≥98%
Packaging: 10mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21280
Product name: Velpatasvir
Purity: ≥98%
Packaging: 50mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 21280
Product name: Velpatasvir
Purity: ≥98%
Packaging: 100mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 21280
Product name: Velpatasvir
Purity: ≥98%
Packaging: 250mg
Price: $298
Updated: 2024/03/01

TRC

Product number: V116000
Product name: Velpatasvir
Packaging: 500mg
Price: $470
Updated: 2021/12/16

More

Less

Velpatasvir Chemical Properties,Usage,Production

Description

Velpatasvir (1377049-84-7) is an extremely potent pan-genotypic hepatitis C virus (HCV) NS5A inhibitor.1 It is a component of Epclusa? and Vosevi?, two clinically useful medications with 98% and 97%, respectively, cure rates for HCV.? It displayed EC50’s for GTs 1-4, 6a ranging from 6-16 pM, GT5a at 75 pM, and GT6e at 130 pM. Velpatasvir also displayed an excellent barrier to viral resistance. It has been shown in silico, that velpatasvir binds to the SARS-CoV-2 spike protein and may be a potential therapeutic.2

Uses

Velpatasvir is a NS5A inhibitor in patients with hepatitis C (HCV) infection.

Definition

ChEBI: Velpatasvir is a complex organic heteropentacyclic compound that is a hepatitis C virus nonstructural protein 5A inhibitor used in combination with sofosbuvir (under the brand name Epclusa) for treatment of patients with chronic hepatitis C of all six major genotypes. It has a role as an antiviral drug and a hepatitis C virus nonstructural protein 5A inhibitor. It is an organic heteropentacyclic compound, a N-acylpyrrolidine, a L-valine derivative, a carbamate ester, a member of imidazoles, a ring assembly and an ether.

brand name

Epclusa, Sofosvel, Velpanat (all in combination with sofosbuvir)

References

Link et al. (2019), Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi? and Epclusa?; Bioorg. Med. Chem. Lett., 29 2415 Kadioglu et al. (2020), Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning; Comput. Biol. Med. 133 104359

Velpatasvir Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Velpatasvir Suppliers

China 253 India 10 United States 12 Global 275

Hangzhou Cheminspire Technology Co., Ltd.

Tel: 0571-89081561; 10006559855
Fax: 0571 89081561
Email: info@cheminspire.com
Country: China
ProdList: 412
Advantage: 58

INTERCHEMIE NANJING PHARMATECH CO., LTD

Tel: 13656237714 13656237714
Fax: 0512-65852853
Email: xiaokunfu@kyyykj.com
Country: China
ProdList: 295
Advantage: 55

Shanghai Neff Biotechnology Co., LTD

Tel: 14782051321
Email: market@lifebiology.cn
Country: China
ProdList: 149
Advantage: 58

Shanghai jing Hao pharmaceutical technology co., LTD

Tel: 021-68900963 15618693615
Fax: 021-68900963
Email: sales@jinghaopharma.com
Country: China
ProdList: 289
Advantage: 58

NANJING ZENJI PHARMACEUTICALS

Tel: 025-58231105-8151
Fax: 025-83172562
Email: marketing@zenjipharma.com
Country: China
ProdList: 440
Advantage: 58

Nanjing Lebang Pharmaceutical Technology Co., Ltd

Tel: 18860950986
Email: tangmanman@lebangpharma.com
Country: China
ProdList: 566
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8836
Advantage: 52

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 7195
Advantage: 65

More

Less

View Lastest Price from Velpatasvir manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Velpatasvir 1377049-84-7
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%-102%
Supply Ability: 10 KGS
Release date: 2021-06-16

shandong perfect biotechnology co.ltd

Product: Velpatasvir(PVP) 1377049-84-7
Price: US $0.00/g
Min. Order: 1g
Purity: 98% HPLC
Supply Ability: 100kg
Release date: 2023-08-14

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Velpatasvir 1377049-84-7
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-09-04

1377049-84-7, VelpatasvirRelated Search:

(S)-1-tert-Butyl 5-methyl 2-((tert-butoxycarbonyl)amino)pentanedioate ZANAMIVIR HYDRATE Dutasteride Tacrolimus Zofenopril calcium Sofosbuvir Rituximab Levofloxacin hydrochloride (2S,4S)-1-(tert-butoxycarbonyl)-4-(MethoxyMethyl)pyrrolidine-2-carboxylic acid N-BOC-CIS-4-CYANO-L-PROLINE METHYL ESTER Velpatasvir intermediate Velpatasvir intermediate Velpatasvir intermediate (R)-2-(methoxycarbonylamino)-2-phenylacetic acid Velpatasvir Co Povidone Velpatasvir intermediate (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid BOC-L-PYROGLUTAMIC ACID BENZYL ESTER

Velpatasvir

GS 5816

velpatasvir(GS-5816)

methyl ((2s)-1-((2s,5s)-2-(9-(2-((2s,4s)-1-((2r)-2-((methoxycarbonyl)amino)-2-phenylacetyl)-4-(methoxymethyl)pyrrolidin-2-yl)-1h-imidazol-5-yl)-1,11-dihydroisochromeno(4',3':6,7)naphtho(1,2-d)imidazol-2-yl)-5-methylpyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

Velpatasvir API

Unifiram (DM-232)

GS 5816;GS-5816

CS-2204

Velpatasvir (Carbamic acid, N-[(1R)-2-[(2S,4S)-2-[4-[1,11-dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4',3':6,7]naphth[1,2-d]imidazol-9-yl]-1H- imidazol-2-yl]-4-(methoxymethyl)-1-pyrrol

Methyl [(2S)-1-[(2S,5S)-2-[9-[2-[(2S,4S)-1-[(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl]-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl]-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-2-yl]-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-y

MFCD28411371

Product:Velpatasvir

Carbamic acid, N-[(1R)-2-[(2S,4S)-2-[5-[1,11-dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4',3':6,7]naphth[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)-1-pyrrolidinyl]-2-oxo-

Velpatasvir intermediate A13

Carbamic acid, N-[(1R)-2-[(2S,4S)-2-[5-[1,11-dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4',3':6,7]naphth[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)-1-pyrrolidinyl]-2-oxo-1-phenylethyl]-, methyl ester

Velpatasvir (10mM in DMSO)

GS-5816(Velpatasvir)

TIANFU CHEM Velpatasvir

Velpatasvir(PVP)

Velpatasvir inteVelpatasvir intermediate A13rmediate A13

Vipataivir

N-(1R)-2-(2S,4S)-2-5-1,11-Dihydro-2-(2S,5S)-1-(2S)-2-(methoxycarbonyl)amino-3-methyl-1-oxo-butyl-5-methylpyrrolidin-2-yl2benzopyrano4',3':6,7naphtho1,2-dimidazol-9-yl-1H-imidazol-2-yl-4-(methoxymethyl)-pyrrolidin-1-yl-2-oxo-1-phenylethylcarbamic acid methyl ester

Vipatavir

Methyl ((2S)-1-((2S,5S)-2-(9-(2-((2S,4S)-1-((2R)-2-((methoxycarbonyl)amino)-2-phenylacetyl)-4-(methoxymethyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-2-yl)-5-methylpyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate

N-(1R)-2-(2S,4S)-2-5-1,11-Dihydro-2-(2S,5S)-1-(2S)-2-(methoxycarbonyl)amino-3-methyl-1-oxo-butyl-5-methylpyrrolidin-2-yl2benzopyrano4',3':6,7naphtho1,2-dimidazol-9-yl-1H-imidazol-2-yl-4-(methoxymethyl)-pyrrolidin-1-yl-2-oxo-1-phenylethylcarbamic acid methyl ester

Carbamic acid, N-[(1R)-2-[(2S,4S)-2-[5-[1,11-dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4′,3′:6,7]naphth[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)-1-pyrrolidinyl]-2-oxo-1-phenylethyl]-, methyl ester (ACI)

1377049-84-7

377049-84-7

C49H54N8O8

1377049-84-7