ChemicalBook > CAS DataBase List > PJ-34

PJ-34

Product Name
PJ-34
CAS No.
344458-15-7
Chemical Name
PJ-34
Synonyms
PI34;CS-723;PJ34 HC;PJ34(HCL);PJ 34;PJ-34;PJ34 hydrochL;PJ-34 USP/EP/BP;PJ 34 Hydrochloride;PARP Inhibitor VIII, PJ34;PJ34 hydrochloride, >=98%
CBNumber
CB8972789
Molecular Formula
C17H17N3O2HCl
Formula Weight
0
MOL File
344458-15-7.mol
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PJ-34 Property

storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
H2O: soluble22mg/mL
form 
White solid
color 
white to yellow
Sensitive 
Light Sensitive & Hygroscopic
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
528150
Product name
PARP Inhibitor VIII, PJ34
Packaging
1mg
Price
$113
Updated
2024/03/01
Sigma-Aldrich
Product number
528150
Product name
PARP Inhibitor VIII, PJ34
Packaging
5mg
Price
$303
Updated
2024/03/01
Alfa Aesar
Product number
J64413
Product name
PARP Inhibitor VIII, PJ34
Packaging
5mg
Price
$186
Updated
2023/06/20
Alfa Aesar
Product number
J64413
Product name
PARP Inhibitor VIII, PJ34
Packaging
25mg
Price
$692
Updated
2023/06/20
Cayman Chemical
Product number
14440
Product name
PJ-34 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
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PJ-34 Chemical Properties,Usage,Production

Description

PJ-34 HCl (344458-15-7) is a potent and selective inhibitor of PARP1 and 2. EC50 = 20 nM.1?Reduces ischemia reperfusion injury in a mouse model.2 Displays anti-inflammatory effects in a transient focal cerebral ischemia mouse model.3 PJ-34 HCl causes PARP1 independent, p21 dependent mitotic arrest.4

Uses

A poly adenosine diphosphate-ribose polymerase inhibitor, attenuates chromate-induced nephrotoxicity. PJ-34 has a lethal effect on breast cancer cells, both in vitro and in vivo, in particular on breast cancer MCF-7.

Uses

PJ-34 hydrochloride hydrate has been used:

  • as a poly(ADP-ribose) polymerase (PARP) inhibitor 1 in rats to test the effect of PAPR1 in neuropathic pain
  • as a component of protein extraction buffer to enable visualization of the high-molecular-weight smear of PARylated proteins in various cell samples
  • as PARP inhibitor in murine MLE-12 epithelial cell line

Definition

ChEBI: PJ34 hydrochloride is a hydrochloride salt prepared from equimolar amounts of PJ34 and hydrochloric acid. It has a role as an angiogenesis inhibitor, an anti-inflammatory agent, an antiatherosclerotic agent, an antineoplastic agent, an apoptosis inducer, a cardioprotective agent, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor and a neuroprotective agent. It contains a PJ34(1+).

General Description

A cell-permeable, water-soluble phenanthridinone-derivative that acts as a potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC50 = 200 μM). Does not act as an antioxidant at higher concentrations (1 μM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke. Also available as a 20 mM solution in H2O(Cat. No. 528151).

Biological Activity

Potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC 50 = 20 nM). ~ 1000-fold more potent than 3-Aminobenzamide . Protects primary neuronal cells from oxygen-glucose deprivation in vitro and reduces infarct size following focal cerebral ischemia in vivo .

Biochem/physiol Actions

Cell permeable: yes

storage

+4°C

References

1) Pellicciari et al. (2008), On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives; Chem. Med. Chem., 3 914 2) Crawford et al. (2010), Postischemic poly (ADP-ribose) polymerase (PARP) inhibition reduces ischemia reperfusion injury in a hind-limb ischemia model; Surgery, 148 110 3) Haddad et al. (2006), Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice; Br. J. Pharmacol., 149 23 4) Madison et al. (2011), The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest; DNA Repair, 10 1003

PJ-34 Preparation Products And Raw materials

Raw materials

Preparation Products

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PJ-34 Suppliers

Canada 1 China 103 India 2 Switzerland 1 United Kingdom 1 United States 18 Global 126
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
Nanjing JinruiJiuAn Biotechnology Co., Ltd.
Tel
025-58196018 800028039
Fax
025-83453306
Email
sales@fartop.net
Country
China
ProdList
2229
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66

344458-15-7, PJ-34Related Search:

4-AMINO-1,8-NAPHTHALIMIDE 3-Aminobenzamide NU1025 PF-01367338 PD 0325901 Erlotinib hydrochloride PD 0332991 HCl ABT 263 Olaparib Rucaparib DPQ ABT-888 3-(4-CHLORO-PHENYL)-QUINOXALINE-5-CARBOXYLIC ACID AMIDE TIQ-A 6(5H)-Phenanthridone PJ-34 2'-METHYL-BIPHENYL-2-YLAMINE N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N DIMETHYLACETAMIDE HYDROCHLORIDE HYDRATE

  • PJ 34 Hydrochloride
  • N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamidehydrochloride
  • PARP Inhibitor VIII, PJ34
  • PJ-34 hydrate hydrochloride
  • CS-723
  • PJ 34;PJ-34
  • PI34
  • 2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide,hydrochloride
  • PJ34 HC
  • AcetaMide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(diMethylaMino)-, hydrochloride
  • N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-(diMethylaMino)acetaMide
  • N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide hydrochloride
  • N,N-diMethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetaMide hydrochloride
  • 2-(DiMethylaMino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetaMide hydrochloride
  • PJ34(HCL)
  • Acetamide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-, hydrochloride (1:1)
  • N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide hydrochloride PJ 34 hydrochloride
  • PJ 34 hydrochloride N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide hydrochloride
  • PJ34 hydrochloride, >=98%
  • 2-(3-(Dimethylamino)-2-oxopropyl)phenanthridin-6(5H)-one hydrochloride
  • n-(6-oxo-5,6-dihydrophenanthridin-2-yl)-(n,n-dimethylamino)acetamide hydrochloride
  • PJ34 hydrochL
  • （PJ-34）2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride
  • PJ-34 USP/EP/BP
  • PARP Inhibitor VIII PJ-34 hydrochloride PJ-34
  • 344458-15-7
  • C17H17N3O2HCl
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  • Heterocycles
  • Inhibitors
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