PJ-34
- Product Name
- PJ-34
- CAS No.
- 344458-15-7
- Chemical Name
- PJ-34
- Synonyms
- PI34;CS-723;PJ34 HC;PJ34(HCL);PJ 34;PJ-34;PJ34 hydrochL;PJ-34 USP/EP/BP;PJ 34 Hydrochloride;PARP Inhibitor VIII, PJ34;PJ34 hydrochloride, >=98%
- CBNumber
- CB8972789
- Molecular Formula
- C17H17N3O2HCl
- Formula Weight
- 0
- MOL File
- 344458-15-7.mol
PJ-34 Property
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- H2O: soluble22mg/mL
- form
- White solid
- color
- white to yellow
- Sensitive
- Light Sensitive & Hygroscopic
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 29339900
N-Bromosuccinimide Price
- Product number
- 528150
- Product name
- PARP Inhibitor VIII, PJ34
- Packaging
- 1mg
- Price
- $113
- Updated
- 2024/03/01
- Product number
- 528150
- Product name
- PARP Inhibitor VIII, PJ34
- Packaging
- 5mg
- Price
- $303
- Updated
- 2024/03/01
- Product number
- J64413
- Product name
- PARP Inhibitor VIII, PJ34
- Packaging
- 5mg
- Price
- $186
- Updated
- 2023/06/20
- Product number
- J64413
- Product name
- PARP Inhibitor VIII, PJ34
- Packaging
- 25mg
- Price
- $692
- Updated
- 2023/06/20
- Product number
- 14440
- Product name
- PJ-34 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
PJ-34 Chemical Properties,Usage,Production
Description
PJ-34 HCl (344458-15-7) is a potent and selective inhibitor of PARP1 and 2. EC50 = 20 nM.1?Reduces ischemia reperfusion injury in a mouse model.2 Displays anti-inflammatory effects in a transient focal cerebral ischemia mouse model.3 PJ-34 HCl causes PARP1 independent, p21 dependent mitotic arrest.4
Uses
A poly adenosine diphosphate-ribose polymerase inhibitor, attenuates chromate-induced nephrotoxicity. PJ-34 has a lethal effect on breast cancer cells, both in vitro and in vivo, in particular on breast cancer MCF-7.
Uses
PJ-34 hydrochloride hydrate has been used:
- as a poly(ADP-ribose) polymerase (PARP) inhibitor 1 in rats to test the effect of PAPR1 in neuropathic pain
- as a component of protein extraction buffer to enable visualization of the high-molecular-weight smear of PARylated proteins in various cell samples
- as PARP inhibitor in murine MLE-12 epithelial cell line
Definition
ChEBI: PJ34 hydrochloride is a hydrochloride salt prepared from equimolar amounts of PJ34 and hydrochloric acid. It has a role as an angiogenesis inhibitor, an anti-inflammatory agent, an antiatherosclerotic agent, an antineoplastic agent, an apoptosis inducer, a cardioprotective agent, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor and a neuroprotective agent. It contains a PJ34(1+).
General Description
A cell-permeable, water-soluble phenanthridinone-derivative that acts as a potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC50 = 200 μM). Does not act as an antioxidant at higher concentrations (1 μM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke. Also available as a 20 mM solution in H2O(Cat. No. 528151).
Biological Activity
Potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC 50 = 20 nM). ~ 1000-fold more potent than 3-Aminobenzamide . Protects primary neuronal cells from oxygen-glucose deprivation in vitro and reduces infarct size following focal cerebral ischemia in vivo .
Biochem/physiol Actions
Cell permeable: yes
storage
+4°C
References
1) Pellicciari et al. (2008), On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives; Chem. Med. Chem., 3 914 2) Crawford et al. (2010), Postischemic poly (ADP-ribose) polymerase (PARP) inhibition reduces ischemia reperfusion injury in a hind-limb ischemia model; Surgery, 148 110 3) Haddad et al. (2006), Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice; Br. J. Pharmacol., 149 23 4) Madison et al. (2011), The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest; DNA Repair, 10 1003
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