PJ-34

ChemicalBook > CAS DataBase List > PJ-34

Product Name: PJ-34
CAS No.: 344458-15-7
Chemical Name: PJ-34
Synonyms: PI34;CS-723;PJ34 HC;PJ34(HCL);PJ 34;PJ-34;PJ34 hydrochL;PJ-34 USP/EP/BP;PJ 34 Hydrochloride;PARP Inhibitor VIII, PJ34;PJ34 hydrochloride, >=98%
CBNumber: CB8972789
Molecular Formula: C17H17N3O2HCl
Formula Weight: 0
MOL File: 344458-15-7.mol

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PJ-34 Property

storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: H2O: soluble22mg/mL
form: White solid
color: white to yellow
Sensitive: Light Sensitive & Hygroscopic
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 528150
Product name: PARP Inhibitor VIII, PJ34
Packaging: 1mg
Price: $113
Updated: 2024/03/01

Sigma-Aldrich

Product number: 528150
Product name: PARP Inhibitor VIII, PJ34
Packaging: 5mg
Price: $303
Updated: 2024/03/01

Alfa Aesar

Product number: J64413
Product name: PARP Inhibitor VIII, PJ34
Packaging: 5mg
Price: $186
Updated: 2023/06/20

Alfa Aesar

Product number: J64413
Product name: PARP Inhibitor VIII, PJ34
Packaging: 25mg
Price: $692
Updated: 2023/06/20

Cayman Chemical

Product number: 14440
Product name: PJ-34 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

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PJ-34 Chemical Properties,Usage,Production

Description

PJ-34 HCl (344458-15-7) is a potent and selective inhibitor of PARP1 and 2. EC50 = 20 nM.1?Reduces ischemia reperfusion injury in a mouse model.2 Displays anti-inflammatory effects in a transient focal cerebral ischemia mouse model.3 PJ-34 HCl causes PARP1 independent, p21 dependent mitotic arrest.4

Uses

A poly adenosine diphosphate-ribose polymerase inhibitor, attenuates chromate-induced nephrotoxicity. PJ-34 has a lethal effect on breast cancer cells, both in vitro and in vivo, in particular on breast cancer MCF-7.

Uses

PJ-34 hydrochloride hydrate has been used:

as a poly(ADP-ribose) polymerase (PARP) inhibitor 1 in rats to test the effect of PAPR1 in neuropathic pain
as a component of protein extraction buffer to enable visualization of the high-molecular-weight smear of PARylated proteins in various cell samples
as PARP inhibitor in murine MLE-12 epithelial cell line

Definition

ChEBI: PJ34 hydrochloride is a hydrochloride salt prepared from equimolar amounts of PJ34 and hydrochloric acid. It has a role as an angiogenesis inhibitor, an anti-inflammatory agent, an antiatherosclerotic agent, an antineoplastic agent, an apoptosis inducer, a cardioprotective agent, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor and a neuroprotective agent. It contains a PJ34(1+).

General Description

A cell-permeable, water-soluble phenanthridinone-derivative that acts as a potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC₅₀ = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC₅₀ = 200 μM). Does not act as an antioxidant at higher concentrations (1 μM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke. Also available as a 20 mM solution in H₂O(Cat. No. 528151).

Biological Activity

Potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC 50 = 20 nM). ~ 1000-fold more potent than 3-Aminobenzamide . Protects primary neuronal cells from oxygen-glucose deprivation in vitro and reduces infarct size following focal cerebral ischemia in vivo .

Biochem/physiol Actions

Cell permeable: yes

storage

+4°C

References

1) Pellicciari et al. (2008), On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives; Chem. Med. Chem., 3 914 2) Crawford et al. (2010), Postischemic poly (ADP-ribose) polymerase (PARP) inhibition reduces ischemia reperfusion injury in a hind-limb ischemia model; Surgery, 148 110 3) Haddad et al. (2006), Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice; Br. J. Pharmacol., 149 23 4) Madison et al. (2011), The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest; DNA Repair, 10 1003

PJ-34 Preparation Products And Raw materials

Raw materials

Preparation Products

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PJ-34 Suppliers

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344458-15-7, PJ-34Related Search:

4-AMINO-1,8-NAPHTHALIMIDE 3-Aminobenzamide NU1025 PF-01367338 PD 0325901 Erlotinib hydrochloride PD 0332991 HCl ABT 263 Olaparib Rucaparib DPQ ABT-888 3-(4-CHLORO-PHENYL)-QUINOXALINE-5-CARBOXYLIC ACID AMIDE TIQ-A 6(5H)-Phenanthridone PJ-34 2'-METHYL-BIPHENYL-2-YLAMINE N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N DIMETHYLACETAMIDE HYDROCHLORIDE HYDRATE

PJ 34 Hydrochloride

N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamidehydrochloride

PARP Inhibitor VIII, PJ34

PJ-34 hydrate hydrochloride

CS-723

PJ 34;PJ-34

PI34

2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide,hydrochloride

PJ34 HC

AcetaMide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(diMethylaMino)-, hydrochloride

N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-(diMethylaMino)acetaMide

N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide hydrochloride

N,N-diMethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetaMide hydrochloride

2-(DiMethylaMino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetaMide hydrochloride

PJ34(HCL)

Acetamide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-, hydrochloride (1:1)

N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide hydrochloride PJ 34 hydrochloride

PJ 34 hydrochloride N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide hydrochloride

PJ34 hydrochloride, >=98%

2-(3-(Dimethylamino)-2-oxopropyl)phenanthridin-6(5H)-one hydrochloride

n-(6-oxo-5,6-dihydrophenanthridin-2-yl)-(n,n-dimethylamino)acetamide hydrochloride

PJ34 hydrochL

（PJ-34）2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride

PJ-34 USP/EP/BP

PARP Inhibitor VIII PJ-34 hydrochloride PJ-34

344458-15-7

C17H17N3O2HCl

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