2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid

Product Name: 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid
CAS No.: 763114-26-7
Chemical Name: 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid
Synonyms: EOS-61877;Olapali impurity 25;Olaparib Intermediate 1;Olaparib intermediate 763114-26-7;2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl);2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl);2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)be;2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)Methyl]benzoic acid;2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylm ethyl)benzo;2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic a...
CBNumber: CB92554162
Molecular Formula: C16H11FN2O3
Formula Weight: 298.27
MOL File: 763114-26-7.mol

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2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Property

Melting point:: 260-264°
Density: 1.42
storage temp.: Sealed in dry,Room Temperature
pka: 3.19±0.10(Predicted)
form: powder
color: White to off-white
InChI: InChI=1S/C16H11FN2O3/c17-13-6-5-9(7-12(13)16(21)22)8-14-10-3-1-2-4-11(10)15(20)19-18-14/h1-7H,8H2,(H,19,20)(H,21,22)
InChIKey: PAXLJNGPFJEKQX-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC(CC2C3=C(C=CC=C3)C(=O)NN=2)=CC=C1F

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Safety

HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: F593022
Product name: 2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoicAcid
Packaging: 5g
Price: $95
Updated: 2021/12/16

AK Scientific

Product number: J99535
Product name: 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoicacid
Packaging: 1g
Price: $10
Updated: 2021/12/16

AK Scientific

Product number: Z5110
Product name: 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoicacid
Packaging: 1g
Price: $14
Updated: 2021/12/16

Apolloscientific

Product number: PC200051
Product name: 2-Fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoicacid
Purity: 99%
Packaging: 5g
Price: $32
Updated: 2021/12/16

AK Scientific

Product number: Z5110
Product name: 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoicacid
Packaging: 5g
Price: $54
Updated: 2021/12/16

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2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Chemical Properties,Usage,Production

Uses

2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic Acid is an intermediate used in the synthesis of phthalazinone scaffolds that are potent inhibitors of poly(ADP-ribose) polymerase, and also in the design of isocorydine derivatives with anticancer effect.

Application

2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic Acid is an intermediate in the synthesis of olaparib. Olaparib is a PARP polymerase inhibitor.

Synthesis

Compound 3 (2.6g, 0.011mol)And 2-fluoro-5-formylbenzoic acid (2.1g, 0.012mol)Dissolved in anhydrous tetrahydrofuran (25ml), cooled to 0 ,Slowly add triethylamine (1.0ml, 0.007mol) dropwise, then warm up to room temperature for 5h, then slowly raise the temperature to 70 , add hydrazine hydrate (5.1ml, 0.107mol) for 3h, and drop to room temperature , Add appropriate amount of hydrochloric acid (2mol / L) to adjust the pH to acidic, no longer precipitate solids. Filter with suction, wash the product with water and ethyl acetate, and dry to obtain a yellow solid (1.9g, yield 83%)

References

[1] Patent: CN108558773, 2018, A. Location in patent: Paragraph 0017; 0021; 0026
[2] Patent: CN108794405, 2018, A. Location in patent: Paragraph 0036; 0039; 0044; 0058; 0063
[3] Patent: CN106146504, 2016, A. Location in patent: Paragraph 0136; 0137; 0138; 0151; 0152
[4] Patent: WO2012/71684, 2012, A1. Location in patent: Page/Page column 23-24
[5] Patent: WO2012/166983, 2012, A1. Location in patent: Page/Page column 70-71

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 763114-26-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 20tons
Release date: 2025-09-02

Jinan Ruitong Biotech Co., Ltd.

Product: 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid? 763114-26-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-28

Henan Aochuang Chemical Co.,Ltd.

Product: 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 763114-26-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-16

763114-26-7, 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acidRelated Search:

2-Methyl-2,4-pentanediol Cyclopentanone 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile 3-oxo-1,3-dihydroisobenzofuran-1-ylphosphonic acid Olaparib CIS-BICYCLO[3.3.0]OCTANE-3,7-DIONE TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzonitrile Veliparib Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride Olaparib Impurity 12 Olaparib Impurity 29 Olaparib Impurity 32 Olaparib Impurity 27 Olaparib Impurity 21 Olaparib Impurity 23 Olaparib Impurity 24 Olaparib Impurity 28

(2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylMethyl)benzoic acid)763114-26-7

2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)Methyl]benzoic acid

Benzoic acid, 5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluoro-

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)

5-[(3,4-Dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluoro-Benzoic acid

2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid

EOS-61877

2-Fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzoic Acid

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)be

2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylm ethyl)benzo

Olaparib intermediate 763114-26-7

2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic a...

C16H11FN2O3 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 763114-26-7

-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid

Olaparib Intermediate 1

2-Fluoro-5-[(4-oxo-3,4-dihydrophthalazin-yl)methyl] benzoic acid

2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoicaci

5- [(3,4-Dihydro-4-oxo-1-phthaloyl) methyl] -2-fluorobenzoic acid

Olapali impurity 25

763114-26-72-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoicacid

2-fluoro-5-((4-oxo-3,4- OH dihydrophthalazin-1-yl)Methyl)benzoic acid

763114-26-7