ChemicalBook > CAS DataBase List > 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid
2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid
Uses- Product Name
- 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid
- CAS No.
- 763114-26-7
- Chemical Name
- 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid
- Synonyms
- EOS-61877;Olapali impurity 25;Olaparib Intermediate 1;Olaparib intermediate 763114-26-7;2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl);2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl);2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)be;2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)Methyl]benzoic acid;2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylm ethyl)benzo;2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic a...
- CBNumber
- CB92554162
- Molecular Formula
- C16H11FN2O3
- Formula Weight
- 298.27
- MOL File
- 763114-26-7.mol
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2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Property
- Density
- 1.42
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.19±0.10(Predicted)
- form
- powder
- color
- White to off-white
- InChI
- InChI=1S/C16H11FN2O3/c17-13-6-5-9(7-12(13)16(21)22)8-14-10-3-1-2-4-11(10)15(20)19-18-14/h1-7H,8H2,(H,19,20)(H,21,22)
- InChIKey
- PAXLJNGPFJEKQX-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(CC2C3=C(C=CC=C3)C(=O)NN=2)=CC=C1F
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Safety
- HS Code
- 2916399090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
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N-Bromosuccinimide Price
TRC
- Product number
- F593022
- Product name
- 2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoicAcid
- Packaging
- 5g
- Price
- $95
- Updated
- 2021/12/16
AK Scientific
- Product number
- Z5110
- Product name
- 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoicacid
- Packaging
- 10g
- Price
- $101
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC200051
- Product name
- 2-Fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoicacid
- Purity
- 99%
- Packaging
- 25g
- Price
- $105
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-M1900
- Product name
- 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoicacid
- Purity
- >98.0%
- Packaging
- 25g
- Price
- $129
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC200051
- Product name
- 2-Fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoicacid
- Purity
- 99%
- Packaging
- 100g
- Price
- $312
- Updated
- 2021/12/16
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2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Chemical Properties,Usage,Production
Uses
2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic Acid is an intermediate used in the synthesis of phthalazinone scaffolds that are potent inhibitors of poly(ADP-ribose) polymerase, and also in the design of isocorydine derivatives with anticancer effect.
Uses
2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic Acid is an intermediate used in the synthesis of phthalazinone scaffolds that are potent inhibitors of poly(ADP-ribose) polymerase, and also in the design of isocorydine derivatives with anticancer effect.
Application
2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic Acid is an intermediate in the synthesis of olaparib. Olaparib is a PARP polymerase inhibitor.
Synthesis
Compound 3 (2.6g, 0.011mol)And 2-fluoro-5-formylbenzoic acid (2.1g, 0.012mol)Dissolved in anhydrous tetrahydrofuran (25ml), cooled to 0 ,Slowly add triethylamine (1.0ml, 0.007mol) dropwise, then warm up to room temperature for 5h, then slowly raise the temperature to 70 , add hydrazine hydrate (5.1ml, 0.107mol) for 3h, and drop to room temperature , Add appropriate amount of hydrochloric acid (2mol / L) to adjust the pH to acidic, no longer precipitate solids. Filter with suction, wash the product with water and ethyl acetate, and dry to obtain a yellow solid (1.9g, yield 83%)
2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid manufacturers
Nanjing Fred Technology Co., Ltd
- Product
- 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 763114-26-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-27
Henan Fengda Chemical Co., Ltd
- Product
- 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 763114-26-7
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-15
Shaanxi Dideu Medichem Co. Ltd
- Product
- 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 763114-26-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-07
763114-26-7, 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acidRelated Search:
2-Methyl-2,4-pentanediol
Cyclopentanone
2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile
3-oxo-1,3-dihydroisobenzofuran-1-ylphosphonic acid
Olaparib
CIS-BICYCLO[3.3.0]OCTANE-3,7-DIONE
TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE
2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzonitrile
Veliparib
Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride
Olaparib Impurity 12
Olaparib Impurity 29
Olaparib Impurity 32
Olaparib Impurity 27
Olaparib Impurity 21
Olaparib Impurity 23
Olaparib Impurity 24
Olaparib Impurity 28