ChemicalBook > CAS DataBase List > 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid
2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid
Uses- Product Name
- 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid
- CAS No.
- 763114-26-7
- Chemical Name
- 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid
- Synonyms
- EOS-61877;Olapali impurity 25;Olaparib Intermediate 1;Olaparib intermediate 763114-26-7;2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl);2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl);2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)be;2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)Methyl]benzoic acid;2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylm ethyl)benzo;2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic a...
- CBNumber
- CB92554162
- Molecular Formula
- C16H11FN2O3
- Formula Weight
- 298.27
- MOL File
- 763114-26-7.mol
More
Less
2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Property
- Density
- 1.42
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.19±0.10(Predicted)
- form
- powder
- color
- White to off-white
- InChI
- InChI=1S/C16H11FN2O3/c17-13-6-5-9(7-12(13)16(21)22)8-14-10-3-1-2-4-11(10)15(20)19-18-14/h1-7H,8H2,(H,19,20)(H,21,22)
- InChIKey
- PAXLJNGPFJEKQX-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(CC2C3=C(C=CC=C3)C(=O)NN=2)=CC=C1F
More
Less
Safety
- HS Code
- 2916399090
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
More
Less
N-Bromosuccinimide Price
TRC
- Product number
- F593022
- Product name
- 2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoicAcid
- Packaging
- 5g
- Price
- $95
- Updated
- 2021/12/16
AK Scientific
- Product number
- Z5110
- Product name
- 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoicacid
- Packaging
- 10g
- Price
- $101
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC200051
- Product name
- 2-Fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoicacid
- Purity
- 99%
- Packaging
- 25g
- Price
- $105
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-M1900
- Product name
- 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoicacid
- Purity
- >98.0%
- Packaging
- 25g
- Price
- $129
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC200051
- Product name
- 2-Fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoicacid
- Purity
- 99%
- Packaging
- 100g
- Price
- $312
- Updated
- 2021/12/16
More
Less
2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Chemical Properties,Usage,Production
Uses
2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic Acid is an intermediate used in the synthesis of phthalazinone scaffolds that are potent inhibitors of poly(ADP-ribose) polymerase, and also in the design of isocorydine derivatives with anticancer effect.
Uses
2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic Acid is an intermediate used in the synthesis of phthalazinone scaffolds that are potent inhibitors of poly(ADP-ribose) polymerase, and also in the design of isocorydine derivatives with anticancer effect.
Application
2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic Acid is an intermediate in the synthesis of olaparib. Olaparib is a PARP polymerase inhibitor.
Synthesis
Compound 3 (2.6g, 0.011mol)And 2-fluoro-5-formylbenzoic acid (2.1g, 0.012mol)Dissolved in anhydrous tetrahydrofuran (25ml), cooled to 0 ,Slowly add triethylamine (1.0ml, 0.007mol) dropwise, then warm up to room temperature for 5h, then slowly raise the temperature to 70 , add hydrazine hydrate (5.1ml, 0.107mol) for 3h, and drop to room temperature , Add appropriate amount of hydrochloric acid (2mol / L) to adjust the pH to acidic, no longer precipitate solids. Filter with suction, wash the product with water and ethyl acetate, and dry to obtain a yellow solid (1.9g, yield 83%)
2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Suppliers
- Tel
- 021-+86-021-38228826 13916602830;
- Fax
- sales@pharmorgsyn.com
- sales@pharmorgsyn.cn
- Country
- China
- ProdList
- 244
- Advantage
- 58
- Tel
- 021-60499358 13661956116
- Fax
- +86 (21) 5106-9359
- info@cs-pharm.com
- Country
- China
- ProdList
- 199
- Advantage
- 58
- Tel
- 5108538618
- Fax
- 86 510 85386988-8017
- suger.wang@chemfuture.com
- Country
- China
- ProdList
- 832
- Advantage
- 65
- Tel
- 0571-86828652 18857119830
- Fax
- 0571-83522824
- sales@chemtrue-bio.com
- Country
- China
- ProdList
- 322
- Advantage
- 58
- Tel
- 18866895588
- Fax
- 0531-82777287
- dingjiaying@shiningpharm.com
- Country
- China
- ProdList
- 95
- Advantage
- 55
- Tel
- 17323066073
- 2538834896@qq.com
- Country
- China
- ProdList
- 79
- Advantage
- 58
- Tel
- 21-68719686 18917373795
- Fax
- 021-68719686
- sales@sh-biobond.cn
- Country
- China
- ProdList
- 81
- Advantage
- 58
- Tel
- 0537-4531868 18553729317
- hdchem@126.com
- Country
- China
- ProdList
- 88
- Advantage
- 55
- Tel
- 022-60182192,1339732154 18722583064
- Fax
- 86-22-60979672
- marketing@pharmacn.com
- Country
- China
- ProdList
- 112
- Advantage
- 61
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- 0514-87325867
- Fax
- 0086-514-87325867
- sales@siyuchem.com
- Country
- China
- ProdList
- 370
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44689
- Advantage
- 61
- Tel
- 21-57721279
- Fax
- QQ：14057904
- sales@shydchem.com.cn
- Country
- China
- ProdList
- 982
- Advantage
- 56
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14103
- Advantage
- 59
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11655
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42958
- Advantage
- 64
- Tel
- 021-50460086-9 15921403865
- Fax
- +86-21-50462321
- han_yajun@dctc.daicel.com
- Country
- China
- ProdList
- 7191
- Advantage
- 65
- Tel
- 21-021-64968085,64968086-5815,5812 13918693646
- Fax
- +86 21 64968087
- bd@rainbowpharma.cn
- Country
- China
- ProdList
- 965
- Advantage
- 65
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7811
- Advantage
- 57
- Tel
- 0086-755-86198205
- acinfo@aemonchem.com
- Country
- China
- ProdList
- 1931
- Advantage
- 57
- Tel
- 0370-2785118 17550508557
- Fax
- QQ：3470079902
- 675141927@qq.com
- Country
- China
- ProdList
- 3203
- Advantage
- 55
- Tel
- 022-60116533 13207668525
- Fax
- 022-60979672
- saleskc@scipharmacn.com
- Country
- China
- ProdList
- 683
- Advantage
- 58
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 010-010-52878169 15801002657
- sales@bjcomparison.com
- Country
- China
- ProdList
- 4988
- Advantage
- 58
- Tel
- 13901585132
- Fax
- +86-25-52131256
- 799750417@qq.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 18017383231 18017383231
- Fax
- qq：2817624287
- lyh_antaeus@163.com
- Country
- China
- ProdList
- 9347
- Advantage
- 55
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 021-60753308-14013
- Fax
- 021-60753309
- Country
- China
- ProdList
- 137
- Advantage
- 55
- Tel
- sales@witofly.com
- Country
- China
- ProdList
- 2864
- Advantage
- 52
- Tel
- +86-28-85122536 85324413
- Fax
- +86-28-85326443
- market@astatech.cn
- Country
- China
- ProdList
- 8026
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
- Tel
- 021-61727342 13611721451
- Fax
- 021-61294107
- sales@chainpharm.com
- Country
- China
- ProdList
- 957
- Advantage
- 58
- Tel
- 180000000
- 3755454181@qq.com
- Country
- China
- ProdList
- 421
- Advantage
- 55
- Tel
- 023-62879767 13996269627;
- Fax
- +86-28-84559521
- sales@conier.com
- Country
- China
- ProdList
- 294
- Advantage
- 56
- Tel
- 15306818081 15306818081
- Fax
- 0571-87234255
- sales@hzread.com
- Country
- China
- ProdList
- 61
- Advantage
- 58
- Tel
- 0512-62857507
- Fax
- +86-512-62857507
- sales@sinorarechem.com
- Country
- China
- ProdList
- 957
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41462
- Advantage
- 60
- Tel
- 0512-63970158-603 18018108880
- Fax
- 0512-63971078
- info@lakestarpharma.com
- Country
- China
- ProdList
- 414
- Advantage
- 59
- Tel
- +86 13590492756
- Fax
- +86 (0)21 57626234
- michael.he@sensechemicals.com
- Country
- China
- ProdList
- 426
- Advantage
- 58
- Tel
- 0531-88803958; 18866891188
- Fax
- 0531-82777287
- zhaojiangxia@shiningpharm.com
- Country
- China
- ProdList
- 275
- Advantage
- 58
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9346
- Advantage
- 58
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18042
- Advantage
- 56
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9648
- Advantage
- 58
- Tel
- 18957373295
- Fax
- -
- Country
- China
- ProdList
- 1580
- Advantage
- 58
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10276
- Advantage
- 55
- Tel
- 021-64609169 18901607656
- Fax
- 021-64609160
- greensnown@163.com
- Country
- China
- ProdList
- 9906
- Advantage
- 50
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 86-021-54933292
- Fax
- 86-021-54933292
- sales@racechemical.com
- Country
- China
- ProdList
- 239
- Advantage
- 50
- Tel
- 025-57018978 18251899859
- Fax
- 025-57018008
- sales@chalf-pharm.com
- Country
- China
- ProdList
- 5806
- Advantage
- 50
- Tel
- 13818361018 13818361018
- Fax
- -
- shzuolin@163.com
- Country
- China
- ProdList
- 69
- Advantage
- 50
More
Less
View Lastest Price from 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid manufacturers
Nanjing Fred Technology Co., Ltd
- Product
- 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 763114-26-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-27
Shaanxi Dideu New Materials Co. Ltd
- Product
- 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 763114-26-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2024-11-13
Shaanxi Dideu Medichem Co. Ltd
- Product
- 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 763114-26-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-07
763114-26-7, 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acidRelated Search:
2-Methyl-2,4-pentanediol
Cyclopentanone
2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile
3-oxo-1,3-dihydroisobenzofuran-1-ylphosphonic acid
Olaparib
CIS-BICYCLO[3.3.0]OCTANE-3,7-DIONE
TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE
2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzonitrile
Veliparib
Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride
Olaparib Impurity 12
Olaparib Impurity 29
Olaparib Impurity 32
Olaparib Impurity 27
Olaparib Impurity 21
Olaparib Impurity 23
Olaparib Impurity 24
Olaparib Impurity 28